News
Faculty & Research
Graduate Program
Undergraduate Program
Postdoctoral Association
Courses
Seminars
Facilities
Library Resources
About the Department
Contact Us

 

Coming Events

11/20/2009 - Characterization of the Function of CAPS in Regulated Exocytosis
 
11/20/2009 - Attention Undergrads
 
11/23/2009 - Contemporary Biochemistry
 

DeLuca Lab - The Vitamin D System
The vitamin D endocrine system is based in the proximal convoluted tubule cells of the kidney. The key enzyme in this system is the 25-hydroxy-1α-hydroxylase or CYP27B1. It is tightly regulated primarily by the parathyroid hormone and 1α,25-dihydroxyvitamin D3 itself. It produces the vitamin D hormone from the circulating form of vitamin D, i.e. 25-hydroxyvitamin D3 by 1α-hydroxylation. The hormone then activates the vitamin D receptor in target organs such as intestinal enterocytes, osteoblasts of bone and renal tubule cells. The activated receptor next stimulates transcription or suppresses transcription of target genes, thus regulating cellular proteins that carry out a variety of functions.

Latest News

Professor Cox Honored

Read More


Takashi Higurashi Earns Award at International Congress on Stress Responses

Read More


Project Crystall Brings Middle-School Students to UW-Madison Lab

Read More


James Ntambi inducted as a Fellow of the Uganda National Academy of Sciences

Read More

 

Copyright 2008 - This page last modified 11/20/2009

Website Feedback, questions or other issues