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289 HONORS INDEPENDENT STUDY
II, SS; 1-2 cr. Prerequisites: Enrolled in the CALS Honors Program and Sophomore or Junior standing, Inter-Ag. 288.
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299 INDEPENDENT STUDY
I, II; 1-3 cr. per sem. Freshman, Sophomore, and Junior students who have the written consent of the instructor may carry Independent Study (299) for a maximum of 3 cr. per semester in Ag. and Life Sciences only. The student must arrange with the faculty member a study plan, the time and place of periodic meetings, the scope of the project and the number of credits to be earned. Independent Study credits may not ordinarily be used to satisfy basic course requirements but may be used to meet elective credits. No more than 6 credits of Independent Study may be counted toward credit for graduation. Prerequisites: Freshman, Sophomore or Junior standing and written consent of instructor. Faculty
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375 SPECIAL TOPICS
I, 3 cr. Open to all students. The course goal is to discuss the theory of evolution and also to explore how the development and refinement of evolutionary theory is a model of how science works. This course will provide an opportunity for students to survey the data, to understand what evolutionary theory is (and what it is not), and to better understand the central role of evolution in producing the remarkable diversity of life on our planet. No prerequisites, satisfies L&S biological sciences breadth requirement.
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399 COORDINATIVE INTERNSHIP
I, II, SS; 1-8 cr. per sem. The Coordinative Internship is to be an organized, sequential, primarily off-campus learning experience for students, which follows some instruction on campus. Consult the Associate Dean for Resident Instruction, College of Agricultural and Life Sciences for details. Prerequisites: Sophomore, Junior or Senior standing and consent of supervising instructor, adviser and internship program coordinator. Faculty
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501 INTRODUCTION TO BIOCHEMISTRY
I, II; 3 cr. Chemistry, nutrition and metabolism of biological systems. Not accepted toward departmental major for M.S. or Ph.D. degrees. Prerequisites: Chemistry 341 or 343. Amasino,Richard M.; Attie,Alan David; Butcher,Samuel E.; Pike,J Wesley
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507 GENERAL BIOCHEMISTRY
I; 3-4 cr. Chemistry of biological materials, intermediary metabolism and protein structure. First semester of a year long first course in Biochemistry. The course is designed and recommended for undergraduate Biochemistry majors, but others are welcome. Prerequisite: Chemistry 345. Honors students register for 4 cr., all others register for 3 cr. Faculty
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508 GENERAL BIOCHEMISTRY
II; 3 cr. Biosynthesis of biological molecules, signal transduction mechanisms, chemistry and metabolism of nucleic acids, protein synthesis, and molecular and cellular biology. Prerequisite: A grade of BC or higher in Biochemistry 507, or consent of instructor. Honors students also register for 1 cr. of Biochem 289 with consent of instructor. Faculty
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510 BIOCHEMICAL PRINCIPLES OF HUMAN AND ANIMAL NUTRITION
(Also Nutritional Sciences 510). I; 3 cr. Lectures. Nutrition for students with a substantial background in biochemistry. Emphasis on biochemical and physiological fundamentals of nutrition. Discussion of protein, fat, carbohydrate, energy, minerals and vitamins and their roles and interrelationships in nutrition and metabolism. Prerequisites: Biochemistry 501 or 602 or consent of instructor. Smith, Eide,David Jeffrey; Smith,Susan Marie
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511 UNDERGRADUATE SEMINAR
I, II; 1 cr. Required of all senior undergraduate majors in biochemistry. Students prepare and orally present a seminar based on a scientific topic. The main goals of the class are for the students to enhance their critical thinking skills, to gain practical experience in the use of various resources to locate and extract information, and to practice the preparation and presentation of a scientific seminar. Through in-depth research of a specific topic, students will be exposed to both primary and secondary biochemical literature and will thus gain an appreciation for the breadth and depth of current research and the process of scientific investigation. Prerequisites: Biochemistry 501, or 507 and 508, or consent of instructor. Faculty
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550 TOPICS IN MEDICAL BIOCHEMISTRY
II; 2 cr Lectures. Biochemical and molecular analysis of selected human diseases. Topics will include atherosclerosis and lipid metabolism, cancer and oncogenes, apoptosis and the cell cycle, human immunodeficiency virus replication and AIDS. Prerequisites: Biochemistry 501, 507 or consent of instructor. Hayes,Colleen E.
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575 BIOLOGY OF VIRUSES
2 cr. Lectures and discussions. Broad coverage of animal virology taught at molecular level. Topics include virus structure, viral replication/lifecycle, aspects of pathogenesis and prevention. Prerequisite: Biocore 301/302, or AP score of 4 or 5 and Zoology 151 or 152; or MM&I 301. Schultz-Cherry. Friesen,Paul Dean; Schultz,Stacey Lynne
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601 PROTEIN AND ENZYME STRUCTURE AND FUNCTION
I; 2 cr. Protein structure and function, enzyme kinetics and mechanisms. Prerequisites: Biochemistry 501 or equivalent, 1 semester of physical chemistry, 1 year of organic chemistry. Holden,Hazel M; Rayment,Ivan
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612 PROKARYOTIC MOLECULAR BIOLOGY
(Also Genetics 612, Bacteriology 612). I; 3 cr. This course surveys topics in prokaryotic molecular biology including the mechanisms of transcription, translation, regulation of gene expression, replication, recombination, and transposition. Prerequisites: background in bacterial genetics or physiology (e.g. equivalent of Bact 370 and/or 526) and a course in basic biochemistry (e.g. equivalent of Biochem 501 or 507-508) or consent of instructor. Gourse.
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620 EUKARYOTIC MOLECULAR BIOLOGY
(Also Pharmacology 620). II; 2 cr. This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. The course is intended for adv undergrads and first yr grad students with a firm knowledge of basic biochemistry. Prereqs: Biochem 508 or equiv. Wassarman, Ansari,Aseem Z; Wassarman,David A
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621 PLANT BIOCHEMISTRY
(Also Botany 621). (Offered Fall 2003 and alternate years) I; 3 cr. Lectures. Biochemistry of photosynthesis, respiration, and other metabolic and biosynthetic processes in plants. Prerequisites: Biochemistry 501 or 602 or consent of instructor. Sharkley, Bednarek,Sebastian York; Sharkey,Thomas D
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624 MECHANISMS OF ENZYME ACTION
I; 2 cr. Lectures. The relation of structure and kinetics to mechanisms of enzymatic catalysis; studies of specific enzymes and enzyme systems. Prereqs: Biochem 501, or 507 and 508, or 601; Chem 561 or 565; or cons instr. Faculty
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625 COENZYMES AND COFACTORS IN ENZYMOLOGY
II, 2 cr. Course will emphasize the importance of coenzyme and cofactors of enzymes in biochemistry. All aspects of the biochemistry of enzymes will be covered, including their biosynthesis as far as is known, the biochemical reactions they catalyze, their chemical and spectroscopic properties, and the mechanisms by which they facilitate biochemical reactions. Prerequisites: Chemistry 343 and 344 or equivalent, Biochemistry 501 or equivalent, Chemistry 561 or 565 or equivalent (may be taken concurrently). Fox,Brian G.; Reed,George H.
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630 CELLULAR SIGNAL TRANSDUCTION MECHANISMS
(Also Pharmacology 630, Zoology 630). I; 3 cr. Provides a comprehensive introduction for advanced undergraduates and graduate students to the essential elements of cellular transduction mechanisms that allow signaling from the cell surface to the nucleus. Emphasis is on receptors, second messengers, protein kinase cascades, and the regulation of gene transcription. Prerequisites: Introductory Biochemistry (Biochemistry 501, or 507 and 508) and Cell Biology (Biocore 303 or Zoology 570 or Pathology 750) or consent of instructor. Ruoho, Bresnick, Anderson, Miyamoto, Keely, Faculty
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636 MACROMOLECULAR CRYSTALLOGRAPHY AND DYNAMICS
II, 2 cr. Provide knowledge of techniques used to obtain detailed structural and dynamic information about biological macromolecules and survey results. Techniques include x-ray diffraction, electron microscopy and molecular dynamics simulations. Designed for advanced undergraduates and beginning graduate students in the biological sciences. Prerequisites: Concurrent or prior biochemistry; calculus, and freshman physics or equivalent. Phillips Jr.,George N.
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651 BIOCHEMICAL METHODS
I, II; 2 cr. Lab. Introduction to modern biochemical laboratory techniques. For advanced undergraduates (biochemistry and other majors) and graduate students not majoring in biochemistry. Prerequisites: Chemistry 221 and Biochemistry 501 or equivalent. Weibel,Douglas B
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660 BIOCHEMICAL TECHNIQUES
I, 1-3 cr. Survey of modern biochemical techniques. Prerequisites: 2 Semesters organic chemistry, physical chemistry, Biochemistry 601 or concurrent registration and consent of instructor. Wickens,Marvin P
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665 BIOPHYSICAL CHEMISTRY
(Also Chemistry 665). I, II; 4 cr. Biochem 665, taught together with the advanced (honors) undergrad course Chem 565, develops the principles of solution thermodynamics and chemical kinetics, and applies this quantitative framework to discuss experimental data and analysis of the thermodynamics (driving forces, coupled conformational changes etc.) and mechanisms of biochemical processes involving proteins, lipids, and nucleic acids in solution. Applications include protein folding, nucleic acid helix formation, micelle formation; ligand binding, cooperative binding and other assembly processes; effects of water, salts, other solutes, temperature and pressure on biochemical processes; protein-nucleic acid interactions and enzyme catalysis. Weekly problem sets develop these applications. Typical enrollment (fall semester) is 20-25 grad students and 75-85 undergrads; 665 students are expected to have some previous background in physical chemistry as well as the 565 prerequisites. Cavagnero,Silvia; Ellis,Jamie Paule
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681/682 SENIOR HONORS THESIS
(For Honors Biochemistry majors only). Yr; 3 cr. per sem. Prerequisites: Senior standing and consent of instructor. Faculty
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691/692 SENIOR THESIS
Yr; 2 cr. per sem. Prerequisites: Senior standing and consent of instructor. Faculty
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699 SPECIAL PROBLEMS
Yr; 1-4 cr. Prerequisites: Senior standing and consent of instructor. Faculty
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702 BIOCHEMICAL MECHANISMS OF REGULATION IN THE CELL
II; 3 cr. Understanding biochemical mechanisms that drive the functioning of eucaryotic cells. Topics to be covered include protein folding and proteolysis, translocation to/through organelles, cellular cytoskeleton, cell division and cell-cell signaling - with a goal of integrating the basic biochemical interactions common to these diverse cellular processes. Prerequisites: Biochemistry 501, 507, or equivalent. Faculty
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703 TOPICS IN EUKARYOTIC REGULATION
(Also Genetics703). II; 2 cr. Focuses on design and interpretation of experiments addressing molecular and genetic mechanisms of eukaryotic regulation. Intended for first year graduate students with a firm knowledge of basic biochemistry, prokaryotic molecular biology and molecular genetics. Prereqs: Biochem 612 or equiv and cons instr. Anderson,Philip; Kimble,Judith E.; Wickens,Marvin P.
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704 CHEMICAL BIOLOGY
II; 2 cr. Structure and function of proteins; nucleic acids and carbohydrates; application of organic chemistry to problems in cell biology. Prerequisites: Biochemistry 501 or equivalent, 1 year of organic chemistry and consent of instructor. Faculty
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711 SEQUENCE ANALYSIS
(Also Animal Health and Biomedical Sciences 711). I (Offered Fall 2004, and alternate years); 2 cr. Lecture. Topics will include overviews of: RNA, DNA and protein structure; mechanisms of genetic change; sequence generation methods; comparison and alignment algorithms; motif recognition; 2D predictions; phylogeny calculations; database searching; discriminating coding criteria; phenotypic selection; phylogenetic reconstruction. Prerequisite: Graduate standing. Faculty
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712 SEQUENCE ANALYSIS LABORATORY
(Also Animal health and Biomedical Sciences 712). I (Offered Fall 2004, and alternate years); 2 cr. Lab. Topics will include: Overview of UNIX including file and directory management; introduction to sequence analysis; database searching; comparison methods; alignments; profiles and profile searching; pattern recognition; phylogenetic reconstruction; bibliographic information retrieval. Prerequisites: Graduate standing; concurrent registration in Biochemistry 711. Faculty
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726 GENE REGULATION IN PROKARYOTES
This course explores various strategies that have evolved to regulate gene expression in microbes, basic bacterial cell biology, and the growing fields of microbial systems and synthetic biology. The greatest emphasis in the course is placed on understanding the diversity of regulatory strategies that have evolved, how they are interconnected, and on knowledge of these strategies can be used to create new regulatory mechanisms and novel microbial applications. Prerequisites: Bacteriology 607 or 612. Landick,Robert C.
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729 ADVANCED TOPICS
I or II; 1-3 cr. Discussions of specialized subject matter of current interest. Prerequisite: Consent of instructor. Faculty
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799 PRACTICUM IN BIOCHEMISTRY TEACHING
1-3 cr. Training and practice in instruction in biochemistry and molecular biology. Prerequisite: Graduate standing and consent of instructor. Wickens,Marvin P
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800 PRACTICAL NUCLEAR MAGNETIC RESONANCE THEORY
I; 2 cr. Lectures. Multiple pulse NMR, off-resonance effects, composite and shaped pulses, product operators, coherence transfer, multi-dimensional NMR, phase cycling, multiple quantum coherence, and cross relaxation. Prerequisite: Consent of instructor. Faculty
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801 BIOCHEMICAL APPLICATIONS OF NUCLEAR MAGNETIC RESONANCE
II; 2 cr. Lectures. Survey of current solution-state nuclear magnetic resonance techniques used in biochemical research; the emphasis will be on how data are acquired and on practical applications. Prerequisite: Consent of instructor. Faculty
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840 REGULATORY MECHANISMS IN PLANT DEVELOPMENT
(Also Botany 840, Genetics 840). I (Offered Fall 2004 and alternate years); 3 cr. Lectures. Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary events in the signal chain leading to modulated gene expression and cellular development. Prerequisites: Biochemistry 501 or 601 and Botany 500 or Biocore 301 and 323. Faculty
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872 SELECTED TOPICS IN MACROMOLECULAR AND BIOPHYSICAL CHEMISTRY
(Also Chemistry 872). II; 2 cr. Prerequisite: Biochemistry 665 and consent of instructors. 872 is an advanced graduate topics course (seminar/discussion format) based on recent literature in biophysical sciences. The course focuses on biophysical techniques, including optical microscopy, scanning probe microscopy, and electrophysiology. Students in 872 present and discuss recent examples of biological questions that have been approached using these tools. Prerequisite: Graduate standing. Faculty
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875 SPECIAL TOPICS
I, II, SS; 1-4 cr. Special topics of current interest to graduate students. Prerequisites: Graduate standing and consent of instructor. Brow,David A.; Rayment,Ivan
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901 SEMINAR - NUTRITION AND METABOLISM
(Advanced). Rep; 1 cr. Presentation of original research results; discussion of recent articles in animal metabolism and nutrition. Prerequisite: Consent of instructor. Faculty
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902 SEMINAR - PLANT BIOCHEMISTRY
(Advanced). Rep; 1 cr. Topics vary from semester to semester and will include bioenergetics in plants, plant metabolism, plant development, and molecular biology of plant systems. Prerequisite: Consent of instructor. Faculty
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903 SEMINAR - MEMBRANE BIOCHEMISTRY
(Advanced). Rep; 1 cr. Reports from recent literature on the subject of membrane biogenesis, including membrane transport and intracellular traffic. Faculty
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905 SEMINAR - BIOMOLECULAR STRUCTURE
(Advanced). Rep; 1 cr. Presentation from the original literature of recent developments in macromolecular structure and function. Prerequisite: Consent of instructor. Butcher,Samuel E.; Holden,Hazel M.; Markley,John L.; Rayment,Ivan
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907 SEMINAR - MOLECULAR GENETICS
(Advanced). Rep; 1 cr. Research reports, special topics, and reports from recent literature in molecular genetics. Prerequisite: Student must be currently enrolled as a student in the Biochemistry or a closely related graduate program, or have consent of instructor. Faculty
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909 SEMINAR - ENZYMOLOGY
(Advanced). Rep; 1 cr. Research reports, special topics, and reports from recent literature in enzymology and enzyme mechanisms. Prerequisite: Consent of instructor. Cleland,W Wallace
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910 SEMINAR - MOLECULAR VIROLOGY
(Advanced). Rep; 1 cr. Research reports, special topics and reports from recent literature in molecular virology. Prerequisite: Consent of instructor. Faculty
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911 SEMINAR - MOLECULAR MECHANISMS OF HORMONE ACTION
(Advanced). Rep; 1 cr. To train students in evaluating published papers in regard to scientific merit and content; provide training in delivering an evaluation of this material to a large group; and to help students and faculty stay abreast of current developments in the area of steroid hormone action. Prerequisite: Consent of instructor. Bedale,Wendy Ann; Clagett-Dame,Margaret; Deluca,Hector F.; Pike,J Wesley; Zella,Julia Beth
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912 SEMINAR - MOLECULAR MECHANISMS OF DEVELOPMENT
(Advanced). Rep; 1 cr. Classical and current papers concerning molecular and genetic mechanisms of eukaryotic development will be presented and discussed. Prerequisite: Consent of instructor. Ansari,Aseem Z; Fox,Catherine Anne; Kimble,Judith E
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913 SEMINAR - RIBOGROUP
(Advanced). Rep; 1 cr. Student-led discussions of RNA-related problems. Prerequisites: Biochemistry 603, Genetics 466 or equivalent; consent of instructor. Brow,David A.; Wickens,Marvin P.
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914 SEMINAR - MOLECULAR BIOSCIENCES
(Advanced) (Also Bacteriology 914, Biomolecular Chemistry 914, Medical Microbiology and Immunology 914). Rep; 1 cr. During the Fall Semester, Molecular Biosciences trainees in their second year of graduate training will present seminars based primarily on literature related to their projects. During the Spring Semester, Molecular Biosciences trainees in their third year of graduate training will present seminars based primarily on their own research. Prerequisite: Consent of instructor. Keck,James L
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915 SEMINAR - COMPUTATION AND INFORMATICS IN BIOLOGY AND MEDICINE
(Also Biostats and Medical Informatics 915, Biomedical Engineering 915, Chemical and Biological Engineering 915, Computer Science 915, Genetics 915). Rep; 1 cr. Participants and outside speakers will discuss current research in computation and informatics in biology and medicine. Required of all Computation and Informatics in Biology and Medicine Program Trainees. Prerequisite: Consent of instructors. Mitchell,Julie C; Pape,Louise; Phillips Jr.,George N.; Shavlik,Jude W.
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916 SEMINAR - CELLULAR MECHANISMS OF PROTEIN and MEMBRANE BIOGENESIS AND TRAFFICKING
(Advanced). Rep; 1 cr. Recent literature relating to cellular aspects of the regulation of protein and membrane biogenesis including protein synthesis, folding, modification, degradation, sorting and trafficking, as well as aspects of molecular chaperone function and membrane trafficking, will be presented and discussed. Prerequisite: Consent of instructor. Bednarek,Sebastian York; Craig,Elizabeth A; Martin,Thomas F J; Wiese,Christiane
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932 BIOTECHNOLOGY TRAINING PROGRAM SEMINAR
(Also Bacteriology 932, Chemical and Biological Engineering 932). Rep; 1 cr. Biotechnology Training Program trainees will present their research for critical review by audience. Prerequisite: Graduate standing. Required of all Biotechnology Training Program trainees Donohue,Timothy J.
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945 SEMINAR - CHEMICAL BIOLOGY
(Also Chemistry 945). (Advanced). Rep; 1 cr. Recent published research in chemical biology and related areas. Intended for advanced graduate students, and required of all NIH Chemistry-Biology Interface Trainees. Prerequisite: Consent of instructors. Kiessling,Laura Lee; Raines,Ronald T; Weibel,Douglas B
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990 RESEARCH
Rep; 1-12 cr. Prerequisites: Graduate standing and consent of instructor. Faculty
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999 SPECIAL PROBLEMS
I; 1-3 cr. Prerequisites: Graduate standing and consent of instructor. Faculty
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