Instructional Team:
The instructional team is drawn from the National Magnetic Resonance Facility at Madison, CESG, and BioMagResBank:
Arash Bahrami, Sam Butcher, Gabriel Comilescu, Hamid Eghbalnia, Klaas Hallenga, Ian Lewis, John Markley, Marco Tonelli,
Eldon Ulrich, W. Milo Westler.
Course Format / Grading:
This course consists of informal presentations by members of the instructional team and discussions. Students are encouraged to ask questions about concepts or material covered in the readings or lectures.
Grading will be on the basis of attendance, class participation, and a term paper to be turned in on the last class day.
Text / Readings:
We will not use a text, although students may wish to purchase one of the recommended ones. Readings will be from the literature.
Term paper:
The term paper should be 10-20 pages and cite 10-20 recent journal articles or reviews.
The topic of the paper should be chosen by 3/15/2008 and cleared with John Markley so that all students taking Biochem 801 have different topics.
The topic can be chosen from the list below or can be devised by the student (with approval of John Markley). A critical analysis of the literature is what is expected.
It is suggested that the term paper topic not be too closely related to your PhD research.
Suggested term paper topics:
• Application of NMR to larger systems (macromolecules, protein-protein, protein-nucleic acid complexes)
• Analysis of motional amplitudes using residual dipolar couplings
• NMR strategies for nucleic acid structure determination
• NMR of paramagnetic proteins
• NMR spectroscopy of membrane proteins
• Role of NMR in metabolomics
• Methods for detecting errors and validating NMR structures of proteins
• Screening for protein small-molecule (drug) interactions
• Combination of SAXS and NMR data for structural refinement
• NMR structures from minimal NMR data
• NMR analysis of plant cell walls
• Isotope labeling approaches for solid-state NMR
Seminars / lectures of interest this semester:
1/28/2008 Robert Powers (University of Nebraska) “Protein Functional Annotation using NMR Ligand Affinity Screens”
Others will be announced as they come to our attention