| Date | Event Information |
|
9/2/2009
|
|
David Michaelis, Lisa Johnson, and Clint Morgan
|
Type:
Class
|
|
Recent Papers from the Chemistry - Biology Interface at Wisconsin
|
|
|
|
|
9/9/2009
|
|
Sam Oliver
|
Type:
Class
|
|
High-throughput selection for cellulase catalysts using chemical complementation. Cornish VW and coworkers. J. Am. Chem. Soc. 2008, 130, 17446 - 17452.
|
Course Material
Reading
Cornish and coworkers
|
|
|
9/16/2009
|
|
Olivia Johnson
|
Type:
Class
|
Olivia Johnson Type: Class
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. Hergenrother PJ and coworkers. J. Mol. Biol. 2009, 388, 144 - 158.
Note: Prof. Hergenrother visits the chemistry department on September 22nd.
|
Course Material
Reading
Hergenrother and coworkers
|
|
|
9/23/2009
|
|
Rebecca Lennen
|
Type:
Class
|
|
FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Gestwicki JE and coworkers. Proc. Natl. Acad. Sci. USA 2009, 106, 1336 - 1341.
|
Course Material
Reading
Gestwicki and coworkers
|
|
|
9/30/2009
|
|
Rachael Carpenter
|
Type:
Class
|
The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals. Crane BR and coworkers. Biochemistry 2009, 48, 1936 - 1944.
Note: Prof. Crane visits the biochemistry department on October 5th.
|
Course Material
Reading
Crane and coworkers
|
|
|
10/7/2009
|
|
Samira Musah
|
Type:
Class
|
Nicotine binding to brain receptors requires a strong cation - pi interaction. Dougherty DA and coworkers. Nature 2009, 458, 534 - 537.
|
Course Material
Reading
Dougherty and coworkers
|
|
|
10/14/2009
|
|
Lisa Johnson
|
Type:
Class
|
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. DeGrado WF and coworkers. Proc. Natl. Acad. Sci. USA 2009, 106, 6968 - 6973.
Note: Prof. Degrado visits the biochemistry department on October 19th.
|
Course Material
Reading
DeGrado and coworkers
|
|
|
10/21/2009
|
|
Adam Courtney
|
Type:
Class
|
|
A general method for scanning unnatural amino acid mutagenesis. Cropp TA and coworkers. ACS Chem. Biol. 2009, 4, 109 - 113.
|
Course Material
Reading
Cropp and coworkers
|
|
|
10/28/2009
|
|
Ethan Lippmann
|
Type:
Class
|
|
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Mallet W and coworkers. Nat. Biotechnol. 2008, 26, 925 - 932.
|
Course Material
Reading
Mallet and coworkers
|
|
|
11/4/2009
|
|
Dave Zhang
|
Type:
Class
|
|
A small molecule that binds Hedgehog and blocks its signaling in human cells. Schreiber SL and coworkers. Nat. Chem. Biol. 2009, 5, 154 - 156.
|
Course Material
Reading
Schreiber and coworkers
|
|
|
11/11/2009
|
|
Clint Morgan
|
Type:
Class
|
|
A blend of small molecules regulates both mating and development in Caenorhabditis elegans. Schroeder FC, Sternberg PW, Edison AS, and coworkers. Nature 2008, 454, 115 - 119.
|
Course Material
Reading
Schroeder, Sternberg, Edison, and coworkers
|
|
|
11/18/2009
|
|
Brad Ryland
|
Type:
Class
|
|
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Sutherland JD and coworkers. Nature 2009, 459, 239 - 242.
|
Course Material
Reading
Sutherland and coworkers
|
|
|
11/25/2009
|
|
Thanksgiving Break
|
Type:
No Class
|
|
|
|
|
|
|
12/2/2009
|
|
Nicole Beauchene
|
Type:
Class
|
|
Photocrosslinking of glycoconjugates using metabolically incorporated diazirine-containing sugars. Kohler JJ and coworkers. Nat. Protoc. 2009, 4, 1044 - 1063.
|
Course Material
Reading
Kohler and coworkers
|
|
|
12/9/2009
|
|
Tony Breitbach
|
Type:
Class
|
|
Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation. Schultz C, Mall MA, and coworkers. Nat. Chem. Biol. 2009, 5, 628 - 630.
|
Course Material
Reading
Schultz, Mall, and coworkers
|
|