Biochemistry Courses

 100 Level  |  200 Level  |  300 Level  |  500 Level  |  600 Level  |  700 Level  |  800 Level  |  900 Level


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100 FRESHMAN BIOCHEMISTRY SEMINAR
Fall, Spring; 1 cr. The Freshman Biochemistry Seminar will introduce freshman to the discipline of biochemistry, to the UW Biochemistry Department, to some of the research projects the faculty are pursuing, to the University, and to the career options open to an individual with a biochemistry undergraduate degree.

104 MOLECULAR MECHANISMS, HUMAN HEALTH and YOU
Fall, Spring; 1 cr. Students in the course will be introduced to the fundamentals of genetics and evolution, and with this foundation we will discuss "big-picture issues" in public health and epidemiology. Specifically, we will discuss the building blocks of the cell, how information is processed from DNA into protein, and how cellular processes are regulated. Current and medically relevant topics such as cancer, inflammation, infections, depression and drug addiction will provide the framework for further discussion of topics such as the regulation of gene expression and cellular metabolism. A major goal of this course is for students to learn about their own health and to be able to explore and question science articles they find in the mainstream media.

289 HONORS INDEPENDENT STUDY
1-2 cr. Prerequisites: Enrolled in the CALS Honors Program and Sophomore or Junior standing, Inter-Ag. 288.

299 INDEPENDENT STUDY
1-3 cr. Freshman, Sophomore, and Junior students who have the written consent of the instructor may carry Independent Study (299) for a maximum of 3 cr. per semester in Ag. and Life Sciences only. The student must arrange with the faculty member a study plan, the time and place of periodic meetings, the scope of the project, and the number of credits to be earned. Independent Study credits may not ordinarily be used to satisfy basic course requirements, but may be used to meet elective credits. No more than 6 credits of Independent Study may be counted toward credit for graduation. Prerequisites: Freshman, Sophomore, or Junior standing and written consent of instructor.

399 COORDINATIVE INTERNSHIP
1-8 cr. The Coordinative Internship is to be an organized, sequential, primarily off-campus learning experience for students, which follows some instruction on campus. Consult the Associate Dean for Resident Instruction, College of Agricultural and Life Sciences for details. Prerequisites: Sophomore, Junior, or Senior standing and consent of supervising instructor, adviser, and internship program coordinator.

501 INTRODUCTION TO BIOCHEMISTRY (Sample Syllabus)
Fall, Spring; 3 cr. Chemistry, nutrition, and metabolism of biological systems. Not accepted toward departmental major for M.S. or Ph.D. degrees. Prerequisites: Chemistry 341 or 343.

507 GENERAL BIOCHEMISTRY 1 (Sample Syllabus)
Fall; 3 cr. Chemistry of biological materials, intermediary metabolism, and protein structure. First semester of a two part course in Biochemistry; Biochemistry 508 is offered in the spring. The course is designed and recommended for undergraduate Biochemistry majors, but others are welcome. Prerequisite: Chemistry 345. Honors credits available with consent of instructor.

508 GENERAL BIOCHEMISTRY 2 (Sample Syllabus)
Spring; 3 cr. Biosynthesis of biological molecules, signal transduction mechanisms, chemistry and metabolism of nucleic acids, protein synthesis, and molecular and cellular biology. Prerequisite: A grade of BC or higher in Biochem 507, or consent of instructor. Honors credits available with consent of instructor.

510 BIOCHEMICAL PRINCIPLES OF HUMAN AND ANIMAL NUTRITION (Also Nutritional Sciences 510). (Sample Syllabus)
Fall, Spring; 3 cr. Nutrition for students with a substantial background in biochemistry. Emphasis on biochemical and physiological fundamentals of nutrition. Discussion of protein, fat, carbohydrate, energy, minerals, and vitamins and their roles and interrelationships in nutrition and metabolism. Prerequisites: Biochem 501 or 602 or consent of instructor.

550 TOPICS IN MEDICAL BIOCHEMISTRY (Sample Syllabus)
Spring; 2 cr. Biochemical and molecular analysis of selected human diseases. Topics will include atherosclerosis and lipid metabolism, cancer and oncogenes, apoptosis and the cell cycle, human immunodeficiency virus replication, and AIDS. Prerequisites: Biochem 501, 507 or consent of instructor.

575 BIOLOGY OF VIRUSES  (Sample Syllabus)
Spring; 2 cr. Lectures and discussions. Broad coverage of animal virology taught at molecular level. Topics include virus structure, viral replication/lifecycle, aspects of pathogenesis and prevention. Prerequisite: Biocore 301/302, or AP score of 4 or 5 and Zoology 151 or 152; or MM&I 301.

601 PROTEIN AND ENZYME STRUCTURE AND FUNCTION (Sample Syllabus)
Fall; 2 cr. Protein structure and function, enzyme kinetics and mechanisms. Prerequisites: Biochem 501 or equivalent, 1 semester of physical chemistry, 1 year of organic chemistry.

606 MATH METHODS - STRUCTURAL BIOLOGY
Fall, even years; 3 cr. Intended to provide a rigorous foundation for mathematical modeling of biological structures. Mathematical techniques include ordinary and partial differential equations, 3D Fourier analysis and optimization. Biological applications include protein folding, molecular dynamics, implicit solvent electrostatics, and molecular interactions. Prerequisites: Math 340 or 341; Comp Sci 302, or consent of instructor.

609 MATH METHODS FOR SYSTEMS BIOLOGY
Spring, odd years; 3 cr. Intended to provide a rigorous foundation for mathematical modeling of biological systems. Mathematical techniques include dynamical systems and differential equations. Applications to biological pathways, including understanding of bistability within chemical reaction systems, are emphasized. Prerequisites: Math 340 or 341; Math 415, or consent of instructor.

612 PROKARYOTIC MOLECULAR BIOLOGY
(Also Genetics 612, Bacteriology 612)
Fall; 3 cr. This course surveys topics in prokaryotic molecular biology including the mechanisms of transcription, translation, regulation of gene expression, replication, recombination, and transposition. Prerequisites: background in bacterial genetics or physiology (Bact 370 or equivalent) and a course in basic biochemistry (Biochem 501or equivalent) or consent of instructor.

619 ADVANCED NUTRITION: INTERMEDIARY METABOLISM OF MACRONUTRIENTS
Spring; 3 cr. Discuss metabolic control; gastrointestinal physiology, nutrient absorption; molecular, cellular, organismal aspects of glucose transport, metabolism, regulation; fuel sensing; molecular regulation of fatty acid, lipid metabolism; cellular, organismal aspects of protein metabolism; hormonal control of metabolism; experimental approaches for studying metabolism.

620 EUKARYOTIC MOLECULAR BIOLOGY
(Also Pharmacology 620) (Sample Syllabus)
Spring; 2 cr. This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. The course is intended for advanced undergrads and first year graduate students with a firm knowledge of basic biochemistry. Prerequisites: Biochem 508 or equivalent.

621 PLANT BIOCHEMISTRY (Also Botany 621)
Spring, odd years; 3 cr. Lectures. Biochemistry of photosynthesis, respiration, and other metabolic and biosynthetic processes in plants. Prerequisites: Biochem 501 or 602 or consent of instructor.

625 COENZYMES AND COFACTORS IN ENZYMOLOGY
Spring; 2 cr. Course will emphasize the importance of coenzyme and cofactors of enzymes in biochemistry. All aspects of the biochemistry of coenzymes will be covered, including their biosynthesis as far as is known, the biochemical reactions they catalyze, their chemical and spectroscopic properties, and the mechanisms by which they facilitate biochemical reactions. Prerequisites: Chemistry 343 and 345 or equivalent, Biochem 501 or equivalent, Chemistry 561 or 565 or equivalent (may be taken concurrently).

630 CELLULAR SIGNAL TRANSDUCTION MECHANISMS (Also Pharmacology 630, Zoology 630) (Sample Syllabus)
Fall; 3 cr. Provides a comprehensive introduction for advanced undergraduates and graduate students to the essential elements of cellular transduction mechanisms that allow signaling from the cell surface to the nucleus. Emphasis is on the synthesis of peptide signals, receptors and receptor trafficking, second messengers, protein kinase cascades, cell cycle regulation, and the regulation of transcription factors and gene transcription. Recommended prerequisites: Introductory Biochemistry (Biochem 501, or 507 and 508) and Cell Biology (Biocore 303 or Zoology 570 or Pathology 750) or consent of instructor.

636 MACROMOLECULAR CRYSTALLOGRAPHY AND DYNAMICS
Spring, even years; 2 cr. Provide knowledge of techniques used to obtain detailed structural and dynamic information about biological macromolecules and survey results. Techniques include x-ray diffraction, electron microscopy and molecular dynamics simulations. Designed for advanced undergraduates and beginning graduate students in the biological sciences. Prerequisites: Concurrent or prior biochemistry; calculus, and freshman physics or equivalent.

651 BIOCHEMICAL METHODS
(Sample Syllabus)
Fall, Spring; 3 cr. Lectures and Lab. Introduction to modern biochemical laboratory techniques. For advanced undergraduates (biochemistry and other majors) and graduate students not majoring in biochemistry. Prerequisites: Chemistry 221 and Biochem 501 or equivalent.

660 BIOCHEMICAL TECHNIQUES 
Fall; 2 cr. Survey of modern biochemical techniques. Prerequisites: 2 semesters of organic chemistry, and intermediate or advanced biochemistry / molecular biology, and consent of instructor.

665 BIOPHYSICAL CHEMISTRY (Also Chemistry 665)
Fall, Spring; 4 cr. Lectures and discussions. Biochem 665, taught together with the advanced (honors) undergraduate course Chem 565, develops the principles of solution thermodynamics and chemical kinetics, and applies this quantitative framework to discuss experimental data and analysis of the thermodynamics (driving forces, coupled conformational changes etc.) and mechanisms of biochemical processes involving proteins, lipids, and nucleic acids in solution. Applications include protein folding, nucleic acid helix formation, micelle formation; ligand binding, cooperative binding and other assembly processes; effects of water, salts, other solutes, temperature and pressure on biochemical processes; protein-nucleic acid interactions and enzyme catalysis. Weekly problem sets develop these applications. Typical enrollment (fall semester) is 20-25 grad students and 75-85 undergrads; 665 students are expected to have some previous background in physical chemistry as well as the 565 prerequisites.

681/682 SENIOR HONORS THESIS (For Honors Biochemistry majors only)
3 cr. Prerequisites: Senior standing and consent of instructor.

691/692 SENIOR THESIS
2 cr. Prerequisites: Senior standing and consent of instructor.

699 SPECIAL PROBLEMS

1-4 cr. Prerequisites: Senior standing and consent of instructor.

701 PROFESSIONAL RESPONSIBILITY (Sample Syllabus)
Fall; 1 cr. Training for the practical aspects of being a scientist. Will cover ethics, peer review, grant writing, science communication, career alternatives, paper writing, experimental design, research documentation, science funding, academic-private interface, scientific fraud, and more. Prerequisite: Admission to the IPiB graduate program.

702 BIOCHEMICAL MECHANISMS OF REGULATION IN THE CELL
Spring; 3 cr. Understanding biochemical mechanisms that drive the functioning of eucaryotic cells. Topics to be covered include protein folding and proteolysis, translocation to/through organelles, cellular cytoskeleton, cell division and cell-cell signaling - with a goal of integrating the basic biochemical interactions common to these diverse cellular processes. Prerequisites: Biochem 501, 507, or equivalent.

703 TOPICS IN EUKARYOTIC REGULATION (Also Genetics 703) (Sample Syllabus)
Spring; 2 cr. Focuses on design and interpretation of experiments addressing molecular and genetic mechanisms of eukaryotic regulation. Intended for first year graduate students with a firm knowledge of basic biochemistry, prokaryotic molecular biology, and molecular genetics. Prerequisites: Biochem 612 or equivalent and consent of instructor.

704 CHEMICAL BIOLOGY
Fall; 2 cr. Structure and function of proteins, nucleic acids and carbohydrates; application of organic chemistry to problems in cell biology, biotechnology, and biomedicine. Prerequisites: Biochem 501 or equivalent, 1 year of organic chemistry and consent of instructor.

726 REGULATION OF GENE EXPRESSION IN PROKARYOTES
Spring; 3cr. An intensive examination of a limited number of systems to illustrate the range of molecular mechanism utilized to control gene expression in bacteria. Prerequisites: Micro/Genetics/Biochem 612 or consent of instructor.

729 ADVANCED TOPICS
Fall, Spring; 1 cr. Seminar: IPiB Seminar. Fourth and Fifth Year IPiB Students only.

729 ADVANCED TOPICS
Fall; 1 cr. Single Molecule Approaches to Biology. The purpose of this course is to introduce students to the different ways in which single molecule experiments can inform scientists about biology as well as provide a fertile “mixing ground” for students interested in single molecule research from different departments and groups (e.g., the Biochemistry and Chemistry departments).

729 ADVANCED TOPICS (Sample Syllabus)
Spring; 1 cr. Seminar: Writing a Scientific Paper. Prerequisite: consent of instructor.

729 ADVANCED TOPICS
Spring; 1 cr. Practicum in Undergraduate Teaching. Prerequisite: consent of instructor.

729 ADVANCED TOPICS
Spring; 3 cr. Metabolic Control Mechanisms and Human Disease. This course is aimed at going deeply into topics in metabolism with high relevance to human disease. The aim is to have more depth than breadth. The emphasis will be on experimental data, its interpretation, and the development of each sub-field. Prerequisite: consent of instructor.

799 PRACTICUM IN BIOCHEMISTRY TEACHING
Fall, Spring; 1-3 cr. Training and practice in instruction in biochemistry and molecular biology. Prerequisite: Graduate standing and consent of instructor.

800 PRACTICAL NUCLEAR MAGNETIC RESONANCE THEORY
Fall; 2 cr. Lectures. Multiple pulse NMR, off-resonance effects, composite and shaped pulses, product operators, coherence transfer, multi-dimensional NMR, phase cycling, multiple quantum coherence, and cross relaxation. Prerequisite: Consent of instructor. Course website: http://www.nmrfam.wisc.edu/links/biochem-800/

801 BIOCHEMICAL APPLICATIONS OF NUCLEAR MAGNETIC RESONANCE
  (Sample Syllabus)
Spring; 2 cr. Lectures. Survey of current solution-state nuclear magnetic resonance techniques used in biochemical research; the emphasis will be on how data are acquired and on practical applications. Prerequisite: Consent of instructor.

840 REGULATORY MECHANISMS IN PLANT DEVELOPMENT (Also Botany 840, Genetics 840)
Fall, even years; 3 cr. Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary events in the signal chain leading to modulated gene expression and cellular development. Prerequisites: Biochem 501 or 601 and Botany 500 or Biocore 301 and 323.

872 SELECTED TOPICS IN MACROMOLECULAR AND BIOPHYSICAL CHEMISTRY (Also Chemistry 872)
Spring; 1 cr. Prerequisite: Biochem 665 and Graduate standing. (Prerequisites, term taught and credits may vary if taking Chemistry 872) Biochemistry 872 is an advanced graduate topics course (seminar/discussion format) based on recent literature in biophysical sciences. The course focuses on biophysical techniques, including optical microscopy, scanning probe microscopy, and electrophysiology. Students in 872 present and discuss recent examples of biological questions that have been approached using these tools. Thomas Record (Biochem 872); Meyer Jackson (Chemistry 872)

875 SPECIAL TOPICS
Fall, Spring; 1-4 cr. Special topics of current interest to graduate students. Prerequisites: Graduate standing and consent of instructor.

901 SEMINAR - NUTRITION AND METABOLISM (Advanced)
1 cr. Presentation of original research results; discussion of recent articles in animal metabolism and nutrition. Prerequisite: Consent of instructor.

902 SEMINAR - PLANT BIOCHEMISTRY (Advanced)
1 cr. Topics vary from semester to semester and will include bioenergetics in plants, plant metabolism, plant development, and molecular biology of plant systems. Prerequisite: Consent of instructor.

903 SEMINAR - MEMBRANE BIOCHEMISTRY (Advanced)
1 cr. Reports from recent literature on the subject of membrane biogenesis, including membrane transport and intracellular traffic.

905 SEMINAR - BIOMOLECULAR STRUCTURE (Advanced)
1 cr. Presentation from the original literature of recent developments in macromolecular structure and function. Prerequisite: Consent of instructor.

906 MODELING FOR BIOCHEMICAL SYSTEMS
Fall 2014; 1 cr. Presentation from the original literature of recent developments in modeling systems. Participants discuss topics relevant to predictive modeling of bioenergy systems. Students present talks and lead brainstorming sessions intended to sharpen their skills at cross-disciplinary communication. Modeling microbes and plants at the genetic, molecular and systems level is emphasized. Prerequisite: Consent of instructor.

907 SEMINAR - MOLECULAR GENETICS
(Advanced)
1 cr. Research reports, special topics, and reports from recent literature in molecular genetics. Prerequisite: Student must be currently enrolled as a student in the Biochemistry or a closely related graduate program, or have consent of instructor.

909 SEMINAR - ENZYMOLOGY (Advanced)
1 cr. Research reports, special topics, and reports from recent literature in enzymology and enzyme mechanisms. Prerequisite: Consent of instructor.

910 SEMINAR - MOLECULAR VIROLOGY
(Advanced)
1 cr. Research reports, special topics and reports from recent literature in molecular virology. Prerequisite: Consent of instructor.

911 SEMINAR - MOLECULAR MECHANISMS OF HORMONE ACTION
(Advanced)
1 cr. To train students in evaluating published papers in regard to scientific merit and content; provide training in delivering an evaluation of this material to a large group; and to help students and faculty stay abreast of current developments in the area of steroid hormone action. Prerequisite: Consent of instructor.

912 SEMINAR - MOLECULAR MECHANISMS OF DEVELOPMENT
(Advanced)
Fall; 1 cr. Classical and current papers concerning molecular and genetic mechanisms of eukaryotic development will be presented and discussed. Prerequisite: Consent of instructor. 

913 SEMINAR - RIBOGROUP
(Advanced)
1 cr. Student-led discussions of RNA-related problems. Prerequisites: Biochem 603, Genetics 466 or equivalent; consent of instructor.

914 SEMINAR - MOLECULAR BIOSCIENCES
(Advanced) (Also Bacteriology 914, Biomolecular Chemistry 914, Medical Microbiology and Immunology 914)
1 cr. During the Fall Semester, Molecular Biosciences trainees in their second year of graduate training will present seminars based primarily on literature related to their projects. During the Spring Semester, Molecular Biosciences trainees in their third year of graduate training will present seminars based primarily on their own research. Prerequisite: Consent of instructor.

915 SEMINAR - COMPUTATION AND INFORMATICS IN BIOLOGY AND MEDICINE
(Also Biostats and Medical Informatics 915, Biomedical Engineering 915, Chemical and Biological Engineering 915, Computer Science 915, Genetics 915)
1 cr. Participants and outside speakers will discuss current research in computation and informatics in biology and medicine. Required of all Computation and Informatics in Biology and Medicine Program Trainees. Prerequisite: Consent of instructors.

916 SEMINAR - CELLULAR MECHANISMS OF PROTEIN and MEMBRANE BIOGENESIS AND TRAFFICKING
(Advanced)
1 cr. Recent literature relating to cellular aspects of the regulation of protein and membrane biogenesis including protein synthesis, folding, modification, degradation, sorting and trafficking, as well as aspects of molecular chaperone function and membrane trafficking, will be presented and discussed. Prerequisite: Consent of instructor.

932 SEMINAR - BIOTECHNOLOGY TRAINING PROGRAM (Also Bacteriology 932, Chemical and Biological Engineering 932)
1 cr. Biotechnology Training Program trainees will present their research for critical review by audience. Prerequisite: Graduate standing. Required of all Biotechnology Training Program trainees.

945 SEMINAR - CHEMICAL BIOLOGY
(Advanced) (Also Chemistry 945)
Spring; 1 cr. Recent published research in chemical biology and related areas. Intended for advanced graduate students, and required of all NIH Chemistry-Biology Interface Trainees. Prerequisite: Consent of instructors.

990 RESEARCH
1-12 cr. Prerequisites: Graduate standing and consent of instructor.

 

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