News
Faculty & Research
Graduate Program
Undergraduate Program
Postdoctoral Association
Courses
Seminars
Facilities
Library Resources
About the Department
Make a Gift
Contact Us

 

Coming Events

10/2/2014 - SFLC : IPiB Tea Time
 
10/3/2014 - Special Seminar: Hirotada Mori
 
10/3/2014 - IPiB Seminar Series - Johnnie Walker
 

DeLuca Lab - The Vitamin D System
The vitamin D endocrine system is based in the proximal convoluted tubule cells of the kidney. The key enzyme in this system is the 25-hydroxy-1α-hydroxylase or CYP27B1. It is tightly regulated primarily by the parathyroid hormone and 1α,25-dihydroxyvitamin D3 itself. It produces the vitamin D hormone from the circulating form of vitamin D, i.e. 25-hydroxyvitamin D3 by 1α-hydroxylation. The hormone then activates the vitamin D receptor in target organs such as intestinal enterocytes, osteoblasts of bone and renal tubule cells. The activated receptor next stimulates transcription or suppresses transcription of target genes, thus regulating cellular proteins that carry out a variety of functions.

Latest News

Laura Kiessling in PNAS: Context Matters

Read More


Biochemistry Sophmore Earns WALSAA Scholarship

Read More


The Shocking Truth About Electric Fish

Read More


Aaron Hoskins Receives Shaw Award

Read More

 

Copyright 2014 - This page last modified 9/30/2014

Website Feedback, questions or other issues