Publications
Chaibub Neto E, Ferrara CT, Attie AD, Yandell B.S.
(2008) Inferring causal phenotype networks from segregating
populations. Genetics.179(2):1089-1100. 
Keller MP, Choi Y, Wang P, Belt Davis D, Rabaglia ME, Oler AT,
Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub
Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS,
Kendziorski C, Attie AD. (2008) A gene expression network model of type
2 diabetes links cell cycle regulation in islets with diabetes
susceptibility. Genome Res. 18(5):706-716.
Blasiole DA, Oler AT, Attie AD. (2008) Regulation of ApoB secretion
by the low density lipoprotein receptor requires exit from the
endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem.
25;283(17):11374-11381.
Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR,
Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard
CB, Attie AD. (2008) Genetic networks of liver metabolism revealed by
integration of metabolic and transcriptional profiling. PLoS Genet.
14;4(3):10000034.
Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM,
Attie AD. (2008) Liver gene expression analysis reveals endoplasmic
reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a
very low-fat diet. Physiol Genomics. 13;33(3):361-372.
Oler AT, Attie AD. (2008) A rapid, microplate SNP genotype assay for the leptinob allele. J Lipid Res. 49(5):1126-1129.
Blasiole DA, Davis RA, Attie AD. (2007) The physiological and
molecular regulation of lipoprotein assembly and secretion. Mol
Biosyst. 3(9):608-19.
Nassoury, N., Blasiole, D., Oler, A.T., Hamelin, J., Prat, A.,
Attie, A.D., and Seidah, N.G. (2007) The cellular trafficking of the
secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Traffic 8,718-732.
Goodarzi, M.O., Lehman, D.M., Taylor, K.D., Guo, X., Cui, J.,
Quiñones, J.J., Clee, S.M., Hsueh, W.A., Yang, H., Attie, A.D., Stern,
M.P., Rotter, J.I. (2007) SORCS1: A novel human type 2 diabetes
susceptibility gene suggested by the mouse. Diabetes 56,1922-1929.
Clee, S.M. and Attie, A.D. The genetic landscape of type 2 diabetes in mice. Endocrine Reviews.
Attie, A.D., Sober, E., Numbers, R.L., Amasino, R.M., Cox, B.,
Berceau, T., Powell, T., and Cox, M.M. (2006) Defending science
education against intelligent design: a call to action. J. Clin.
Invest.116,1134-1138.
Attie, A.D. (2006) A Liver-High-Density Lipoprotein-Ovarian Axis of Fertility. Endocrinology 147(4):1575-1576.
Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards,
O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Stapleton, D.S.,
Gray-Keller, M.P., Boronenkov, I., Raess, P.W., Flowers, M.T., and
Attie, A.D. (2006) Positional cloning of a type 2 diabetes quanitative
trait locus. Nature Genetics 38,688-693.
Lan, H. Chen, M., Byers, J.E., Yandell, B.S., Stapelton, D.S., Mata,
C.M., Mui, E.T., Flowers, M.T., Scheuler, K.L., Manly, K.F., Williams,
R.W., Kendziorski, C.M., Attie, A.D. (2006) Combined expression trait
correlations and expression quantative trait locus mapping. PLoS
Genetics 2:52-61.
Kendziorski, C. M. ,Chen, M., Yuan, M., Lan, H. and Attie, A. D.
(2005) Statistical Methods for Expression Quantitative Trait Loci
(eQTL) Mapping. Biometrics DOI: 10.1111/j.1541-0420.
Rabagia, M.E., Gray-Keller, M.P., Attie, A.D. (2005)
α-Ketoisocaproate-induced Hypersecretion of Insulin by Islets from
Diabetes-susceptible Mice: A Role for α-ketoglutarate as a direct
insulin secretagogue. Am. J. Physiol. 289,E218-E224.
Minn, A.H., Lan, H., Rabaglia, M.E., Harlan, D.M., Peculis, B.A.,
Attie, A.D., and Shalev, A. (2005) Increased insulin translation from
an insulin splice-variant overexpressed in diabetes and insulin
resistance. Mol. Endocrinol. 19,794-803.
Clee, S.M., Nadler, S.T., Attie, A.D. (2005) Genetic and genomic studies in the BTBR ob/ob Model of type 2 diabetes. Am. J. Ther. 12,491-498.
Sheth, S.S., Castellani, L.W., Chari, S., Wagg, C., Thipphavong,
C.K., Bodnar, J.S., Tontonoz, P., Attie, A.D., Lopaschuk, G.D., and
Lusis, A.J. Thioredoxin interacting protein (Txnip) deficiency disrupts
the fasting-feeding metabolic transition. (2005) J. Lipid Res.
46,123-134.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W,
Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M,
Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat
A, Seidah NG. NARC-1/PCSK9 and its natural mutants: zymogen cleavage
and effects on the low density lipoprotein (LDL) receptor and LDL
cholesterol. (2004) J Biol Chem. 279,48865-75.
Jin, C., Lan, H., Attie, A.D., Bulutuglo, D., Churchill, G.A., and
Yandell, B.S. (2004) Selective phenotyping for increased efficiency in
mapping studies. Genetics 168,2285-93.
Hui, T.Y., Sheth, S., Diffley, J.M., Potter, D.W., Lusis, A.J.,
Attie, A.D., and Davis, R.A. (2004) Mice lacking thiroedoxin interactin
protein provide evidence linking cellular redox state to appropriate
response to nutritional signals. J. Biol. Chem. 279,24387-24851.
Attie, A.D. (2004) Insig: a significant integrator of hormonal and nutritional signals. J. Clin. Invest. 113,1112-1114.
Attie, A.D. (2004) The mystery of PCSK9. Arteroscl. Thromb. Vasc. Biol. 24,1337-1339.
Lan, H., Rabaglia, M.E., Schueler, K.L., Mata, C., Yandell, B.S.,
and Attie, A.D. (2004) Distinguishing co-variation from causality in
diabetes: a lesson from the protein disulfide isomerase mRNA abundance
trait. Diabetes 53,240-244.
Stoehr, J.P., Byers, J.E., Clee, S.M., Lan, H., Boronenkov, I.,
Schueler, K.M., Yandell, B.S., and Attie, A.D. (2004) Identification of
major quantitative trait loci controlling body weight variation in
ob/ob mice. Diabetes 53,245-249.
Lan, H., Rabaglia, M.E., Stoehr, J.P., Nadler, S.T., Schueler, K.L.,
Zou, F., Yandell, B.S., and Attie, A.D. (2003) Gene expression profiles
of non-diabetic and diabetic obese mice suggest a role of hepatic
lipogenic capacity in diabetes susceptibility. Diabetes 52,688-700.
Lan, H., Stoehr, J.P., Nadler, S.T, Schueler, K.M., Yandell, B.S.,
and Attie, A.D. (2003) Dimension reduction for mapping mRNA abundance
as quantitative traits. Genetics 164,1607-1614.
Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S.
(2003) Adaptive gene picking with microarray data: detecting important
low abundance signals. In: The Analysis of Gene Expression Data:
Methods and Software, ed by G Parmigiani, ES Garrett, RA Irizarry, SL
Zeger. Springer-Verlag.
C.M. Kendziorski, Y. Zhang, H. Lan, A.D. Attie, (2003) The
efficiency of pooling mRNA in microarray experiments. Biostatistics
465-477.
Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S.
(2002) Adaptive gene picking with microarray data: detecting important
low abundance signals. In: The Analysis of Gene Expression Data:
Methods and Software, ed by G Lan, H., Rabaglia, M.E., Stoehr, J.P.
Ntambi, J.M., Miyazaki, M., Stoehr, J.P., Lan, H., Kendziorski,
C.M., Yandell, B.S., Cohen, P., Friedman, J.M., and Attie, A.D. (2002)
Loss of Stearoyl CoA Desaturase-1 Function Protects mice against
adiposity. Proc. Natl. Acad. Sci. USA 99,11482-11486.
Attie, A.D., Hamon, Y., Brooks-Wilson, A.R., Gray-Keller, M.P.,
MacDonald, M.L.E., Rigot, V., Tebon, A., Zhang, L-H, Mulligan, J.,
Singaraja, R.R., Bitgood, J.J., Cook, M.E.., Kastelein, J.J.P.,
Chimini, G., and Hayden, M.R. (2002) Identification and functional
analysis of a naturally occurring E89K mutation in the ABCA1 gene of
the WHAM chicken. J. Lipid Res. 43,43,1610-1617.
Attie, A.D., Krauss, R.M., Gray-Keller, M.P., Brownlie, A.,
Miyazaki, M., Kastelein, J.J., Lusis, A.J., Stalenhoef, A.F.H., Stoehr,
J.P., Hayden, M.R., and Ntambi, J.M. (2002) Relationship between
stearoyl-CoA desaturase activity and plasma triglycerides in human and
mouse hypertriglyceridemia. J. Lipid Res. 43,1899-1907.
Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, and Attie,
Alan D. (2002)Endoplasmic reticulum localization of the low density
lipoprotein receptor mediates presecretory degradation of
apolipoprotein B.PNAS April 2, 2002 vol. 99 no. 7 4337?4342.
Attie, A.D., Kastelein, J.P., and Hayden, M.R. (2001) Pivotal role
of ABCA1 in reverse cholesterol transport influencing HDL levels and
susceptibility to atherosclerosis. J. Lipid Res. 42,1717-1726.
Nadler, S.T., Stoehr, J.P., Rabaglia, M.A., Schueler, K.L.,
Birnbaum, M.J., and Attie, A.D. (2001) Normal Akt/PKB with reduced PI3K
activation in insulin-resistant mice. Am. J. Physiol. 249,
E1249-E1254.
Nadler, S.T. and Attie, A.D. (2001) Please pass the chips. Genomic
Insights into obesity and diabetes. J. Nutrition 131,2078-2081.
Stoehr, J.P., Nadler, S.T., Schueler, K.L., Rabaglia, M.E.,
Yandell, B.S., Metz, S.A., and Attie, A.D. (2000) Genetic obesity
unmasks non-linear interactions between murine Type 2 Diabetes
susceptibility loci. Diabetes 49,1946-1954.
Nadler, S.T., Stoehr, J.P., Schueler, K.M., Tanimoto, G., Yandell,
B.S., and Attie, A.D. (2000) The expression of adipogenic genes is
decreased in obesity and diabetes mellitus. Proc. Natl. Acad. Sci. USA
97, 11371-11376.
Twisk, J., Gillian-Daniel, D.L., Tebon, A., Barrett, P.H.R., and
Attie, A.D. (2000) The role of the LDL receptor in apolipoprotein B
secretion. J. Clin. Invest. 105, 521-532.