Attie Recent Publications
Neto, E.C., Flowers, J.B., Zhao,E., Attie, A.D., and Yandell, B.S. (2008)Inferring causal phenotype networks from segregating populations. Genetics.179(2):1089-1100.
Keller MP, Choi Y, Wang P, Belt Davis D, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD. (2008) A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res. 18(5):706-716.
Blasiole DA, Oler AT, Attie AD. (2008) Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem. 25;283(17):11374-11381.
Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD. (2008) Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet. 14;4(3):10000034.
Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM, Attie AD. (2008) Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics. 13;33(3):361-372.
Oler AT, Attie AD. (2008) A rapid, microplate SNP genotype assay for the leptinob allele. J Lipid Res. 49(5):1126-1129
Blasiole DA, Davis RA, Attie AD. (2007) The physiological and molecular regulation of lipoprotein assembly and secretion. Mol Biosyst. 3(9):608-19.
Nassoury, N., Blasiole, D., Oler, A.T., Hamelin, J., Prat, A., Attie, A.D., and Seidah, N.G. (2007) The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic 8,718-732. 
Goodarzi, M.O., Lehman, D.M., Taylor, K.D., Guo, X., Cui, J., Quiñones, J.J., Clee, S.M., Hsueh, W.A., Yang, H., Attie, A.D., Stern, M.P., Rotter, J.I. (2007) SORCS1: A novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes 56,1922-1929.
Clee, S.M. and Attie, A.D. The genetic landscape of type 2 diabetes in mice. Endocrine Reviews.
Attie, A.D., Sober, E., Numbers, R.L., Amasino, R.M., Cox, B., Berceau, T., Powell, T., and Cox, M.M. (2006) Defending science education against intelligent design: a call to action. J. Clin. Invest.116,1134-1138.
Attie, A.D. (2006) A Liver-High-Density Lipoprotein-Ovarian Axis of Fertility. Endocrinology 147(4):1575-1576.
Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards, O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Stapleton, D.S., Gray-Keller, M.P., Boronenkov, I., Raess, P.W., Flowers, M.T., and Attie, A.D. (2006) Positional cloning of a type 2 diabetes quanitative trait locus. Nature Genetics 38,688-693.
Lan, H. Chen, M., Byers, J.E., Yandell, B.S., Stapelton, D.S., Mata, C.M., Mui, E.T., Flowers, M.T., Scheuler, K.L., Manly, K.F., Williams, R.W., Kendziorski, C.M., Attie, A.D. (2006) Combined expression trait correlations and expression quantative trait locus mapping. PLoS Genetics 2:52-61.
Kendziorski, C. M. ,Chen, M., Yuan, M., Lan, H. and Attie, A. D. (2005) Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping. Biometrics DOI: 10.1111/j.1541-0420.
Rabagia, M.E., Gray-Keller, M.P., Attie, A.D. (2005) α-Ketoisocaproate-induced Hypersecretion of Insulin by Islets from Diabetes-susceptible Mice: A Role for α-ketoglutarate as a direct insulin secretagogue. Am. J. Physiol. 289,E218-E224.
Minn, A.H., Lan, H., Rabaglia, M.E., Harlan, D.M., Peculis, B.A., Attie, A.D., and Shalev, A. (2005) Increased insulin translation from an insulin splice-variant overexpressed in diabetes and insulin resistance. Mol. Endocrinol. 19,794-803.
Clee, S.M., Nadler, S.T., Attie, A.D. (2005) Genetic and genomic studies in the BTBR ob/ob Model of type 2 diabetes. Am. J. Ther. 12,491-498.
Sheth, S.S., Castellani, L.W., Chari, S., Wagg, C., Thipphavong, C.K., Bodnar, J.S., Tontonoz, P., Attie, A.D., Lopaschuk, G.D., and Lusis, A.J. Thioredoxin interacting protein (Txnip) deficiency disrupts the fasting-feeding metabolic transition. (2005) J. Lipid Res. 46,123-134.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat A, Seidah NG. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. (2004) J Biol Chem. 279,48865-75.
Jin, C., Lan, H., Attie, A.D., Bulutuglo, D., Churchill, G.A., and Yandell, B.S. (2004) Selective phenotyping for increased efficiency in mapping studies. Genetics 168,2285-93.
Hui, T.Y., Sheth, S., Diffley, J.M., Potter, D.W., Lusis, A.J., Attie, A.D., and Davis, R.A. (2004) Mice lacking thiroedoxin interactin protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J. Biol. Chem. 279,24387-24851.
Attie, A.D. (2004) Insig: a significant integrator of hormonal and nutritional signals. J. Clin. Invest. 113,1112-1114.
Attie, A.D. (2004) The mystery of PCSK9. Arteroscl. Thromb. Vasc. Biol. 24,1337-1339.
Lan, H., Rabaglia, M.E., Schueler, K.L., Mata, C., Yandell, B.S., and Attie, A.D. (2004) Distinguishing co-variation from causality in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait. Diabetes 53,240-244.
Stoehr, J.P., Byers, J.E., Clee, S.M., Lan, H., Boronenkov, I., Schueler, K.M., Yandell, B.S., and Attie, A.D. (2004) Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes 53,245-249.
Lan, H., Rabaglia, M.E., Stoehr, J.P., Nadler, S.T., Schueler, K.L., Zou, F., Yandell, B.S., and Attie, A.D. (2003) Gene expression profiles of non-diabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52,688-700.
Lan, H., Stoehr, J.P., Nadler, S.T, Schueler, K.M., Yandell, B.S., and Attie, A.D. (2003) Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics 164,1607-1614.
Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2003) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Parmigiani, ES Garrett, RA Irizarry, SL Zeger. Springer-Verlag.
C.M. Kendziorski, Y. Zhang, H. Lan, A.D. Attie, (2003) The efficiency of pooling mRNA in microarray experiments. Biostatistics 465-477.
Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2002) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Lan, H., Rabaglia, M.E., Stoehr, J.P.
Ntambi, J.M., Miyazaki, M., Stoehr, J.P., Lan, H., Kendziorski, C.M., Yandell, B.S., Cohen, P., Friedman, J.M., and Attie, A.D. (2002) Loss of Stearoyl CoA Desaturase-1 Function Protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99,11482-11486.
Attie, A.D., Hamon, Y., Brooks-Wilson, A.R., Gray-Keller, M.P., MacDonald, M.L.E., Rigot, V., Tebon, A., Zhang, L-H, Mulligan, J., Singaraja, R.R., Bitgood, J.J., Cook, M.E.., Kastelein, J.J.P., Chimini, G., and Hayden, M.R. (2002) Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J. Lipid Res. 43,43,1610-1617.
Attie, A.D., Krauss, R.M., Gray-Keller, M.P., Brownlie, A., Miyazaki, M., Kastelein, J.J., Lusis, A.J., Stalenhoef, A.F.H., Stoehr, J.P., Hayden, M.R., and Ntambi, J.M. (2002) Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 43,1899-1907.
Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, and Attie, Alan D. (2002)Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.PNAS April 2, 2002 vol. 99 no. 7 4337?4342.
Attie, A.D., Kastelein, J.P., and Hayden, M.R. (2001) Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42,1717-1726.
Nadler, S.T., Stoehr, J.P., Rabaglia, M.A., Schueler, K.L., Birnbaum, M.J., and Attie, A.D. (2001) Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice. Am. J. Physiol. 249, E1249-E1254.
Nadler, S.T. and Attie, A.D. (2001) Please pass the chips. Genomic Insights into obesity and diabetes. J. Nutrition 131,2078-2081.
Stoehr, J.P., Nadler, S.T., Schueler, K.L., Rabaglia, M.E., Yandell, B.S., Metz, S.A., and Attie, A.D. (2000) Genetic obesity unmasks non-linear interactions between murine Type 2 Diabetes susceptibility loci. Diabetes 49,1946-1954.
Nadler, S.T., Stoehr, J.P., Schueler, K.M., Tanimoto, G., Yandell, B.S., and Attie, A.D. (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc. Natl. Acad. Sci. USA 97, 11371-11376.
Twisk, J., Gillian-Daniel, D.L., Tebon, A., Barrett, P.H.R., and Attie, A.D. (2000) The role of the LDL receptor in apolipoprotein B secretion. J. Clin. Invest. 105, 521-532.