Michael M. Cox - Principal Investigator

Curriculum Vitae

Mailing Address:
Department of Biochemistry
433 Babcock Drive
University of Wisconsin-Madison
Madison, WI 53706-1544

Shipping Address:
Department of Biochemistry
University of Wisconsin-Madison
440 Henry Mall
Madison, WI 53706

Telephone: (608)-262-1181

Fax: (608)-265-5820

Email: cox@biochem.wisc.edu

Carol Pfeffer

Telephone: (608)-263-0858

Email: pfeffer@biochem.wisc.edu

Education and Training:
 9/70-6/74 University of Delaware, B.A., Biology 9/74-8/79 Brandeis University, Ph.D., Biochemistry. Thesis advisor: Dr. William P. Jencks. 1979-1982 Postdoctoral Fellow, Department of Biochemistry, Stanford, University School of Medicine, Stanford, CA 94305 (with Dr. I. R. Lehman).

Professional Employment:
 1983-1987 Assistant Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI  53706 1987-1992 Associate Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI  53706 1992-present  Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI  53706 8/93-present Assistant Chair, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI  53706

Current Research Activity: 
Studies of the mechanism of action of proteins involved in genetic recombination. Present work is focused on the bacterial RecA protein, the bacterial RecF, RecO, RecR, RecG, RuvA, and RuvB proteins, the yeast Rad51 protein, and more broadly on the mechanism of the recombinational DNA repair of stalled replication forks.

Fellowships and Awards: 9/79-9/81 American Cancer Society Postdoctoral Fellowship 9/81-9/82 Bank of America-Giannini Foundation Postdoctoral Fellowship 7/83-6/88 Shaw Fellowship (research award) awarded by the Milwaukee Foundation 7/84-6/89 National Institutes of Health Research Career Development Award 9/84-9/86 March of Dimes-Basil O'Connor Starter Research Grant (research award) 1986-1991 Dreyfus Teacher-Scholar Award 1989 Eli Lilly Award sponsored by the American Chemical Society, Division of Biological Chemistry 1989 Romnes Faculty Fellowship 1994 Spitzer Teaching Award, University of Wisconsin College of Agriculture and Life Sciences 1998 Vilas Associate Award, University of Wisconsin Graduate School 2000 WARF Kellett Mid-Career Faculty Research Award, 2009 University of Wisconsin Regents' Teaching Excellence Award, 2011 Elected American Association for the Advancement of Science (AAAS) Fellow

National/International Service (excluding routine paper/grant review):

2/88, 6/90, 2/02, 6/03, 10/05, 206, 10/07  NIH Microbial Genetics Study Section (Ad hoc); 7/1/91-1/31/97 Assistant Editor, Journal of Biological Chemistry; 7/92 NIH Special Review Committee Site Visit Review;  1/93-6/95 NIH Microbial Physiology and Genetics Study Section; 1998-2001 Council Member, American Society of Biochemistry and Molecular Biology; 1997-present Chief Advisor in development of the Encyclopedia of Life Sciences/Online Encyclopedia,Nature Publishing Group, UK  (launched 2001);  1999-2005 Assistant Editor, Journal of Biological Chemistry; 2001 (November) Organizing Committee, National Academy of Sciences Symposium on Relationships between Replication and Recombination, Irvine, CA; 2002 Meeting co-chair, Nucleic Acids Gordon Conference; 2002-2005 Member, U.S. National Committee for the International Union for Biochemistry and Molecular Biology (USNC/IUBMB);  2002-present Editor, Critical Reviews in Biochemistry and Molecular Biology; 2006 Meeting co-chair, Nucleic Acids Keystone Symposium; 2005-present Editorial Board, BioMed Central Microbiology; 2006-present Advisor, FASEB “Educating About Evolution” Subcommittee; 2007-2010 AAAS Council Delegate, Section on Biological Sciences; 3/2008 Visiting Professor, University of Paris Sud, Orsay, France; 2009 Meeting Chair, FASEB; 1/11-12/13 Editorial Board, Journal of Bacteriology

Major Departmental Service (routine committee work excluded): 1986 - present Chair, departmental space and remodeling committee 1992 - present Chair, new buildings committee. Oversaw design and construction of 1998 building (200,000 GSF). Planning begun on 2006 building (250,000 GSF)

Patent: 2007, Michael M. Cox, Dennis R. Harris, Sergei V. Saveliev, Julie M. Eggington, John R. Battista, Edmond Joivet, and Masashi Tanaka. Method to protect DNA Ends. U.S. Patent Number 7,211,393_2007, Michael M. Cox, Shelley Lusetti, Aimee Eggler, and Nami Haruta. RecA Mutants. U.S. Patent Number 7,176,007_ 2000, Michael M. Cox, Elizabeth Wood and Li-chun Huang, Chromosomal targeting in bacteria using FLP recombinase. U.S. Patent Number 6,140,129.

Students and Postdoctoral Fellows in Training: Rose Byrne, graduate student (MDTP)_Angela Manlick, graduate student (MBTG) _TaeJin Kim, graduate student (IPiB)_Erin Ronayne, graduate student (IPiB)

Former Students and Postdoctoral Fellows:
 Sandra K. Neuendorf:  Senior Lecturer, Department of Chemistry, University of Wisconsin-Oshkosh, Oshkosh, WI_
Scott W. Morrical:  Associate Professor, Department of Biochemistry, University of Vermont, Burlington, VT._Julie F. Senecoff:  Masters Program in Genetic counseling at Arcadia University, PA._Robert C. Bruckner:  Research Investigator, Sterling Winthrop Inc., Collegeville, PA._B. Frank Pugh:  Associate Professor, Department of Molecular and Cellular Biology, The Pennsylvania State University, University Park, PA._Brian C. Schutte:  Adjunct Faculty Instructor/Associate Research Scientist, Department of Pediatrics, and Director of the Child Health Research Center Molecular Core Laboratory, University of Iowa, Iowa City, IA_
Cynthia Gates:  Staff Scientist, Vertex Pharmaceuticals, Cambridge, MA_Leslie Meyer-Leon:  Attorney, Sunstein, Kann, Murphy & Timbers LLP, Boston, MA
_Janet E. Lindsley:  Associate Professor, Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT._Jongwon Lee:  Professor, School of Medicine, Taegu Catholic University, Taegu, Korea_
Scott Umlauf:  Senior Scientist, Powerject Vaccines, Madison, WI_
Li-chun Huang:  Manager, Corautus Genetics, San Jose, CA_Jong-Il Kim:  Research Scientist, Scientific Research Center, Department of Microbiology, Seoul National University, Shilim-Dong, Kwanak-GU, Seoul, Korea
_Wendy Bedale:  Assistant Scientist, Department of Biochemistry, UW-Madison, Madison, WI_Sarita Jain:  Senior Director, Business Development, XenoPort, Inc., Santa Clara, CA
_Koichiro Ishimori:  Associate Professor with Dr. Isao Morishim, Kyoto University, Division of Molecular Engineering, Kyoto, Japan
_Xiao-hong Qian:  President, CEO, GenePharm, Sunnyvale, CA_
Lisa Iype:  Seattle, WA_
Leslie Waite:  Postdoctoral Fellow with Dr. Joanne Engel, University of California, San Francisco, CA_
Kerry MacFarland:  Professor, Department of Biochemistry, Illinois College, Jacksonville, IL_Brian Webb:  Platform Manager, Pierce Biotechnology (ThermoFisher)_Alberto Roca:  Postdoctoral Fellow, University of California, Los Angeles, CA._Paul Marrione: Staff Scientist, PPD Development, Madison, WI_
Natalie Baker:  Science Coordinator, Elementary School, Grant Rapids, MI_
Qun Shan:  Postdoctoral Fellow with Dr. Jasper Rine, University of California, Berkeley, CA._Tanya Arenson:  Staff Scientist, Medlen & Carroll, LLP, Madison, WI._Julie Schultz (Bork): Postdoctoral Fellow with Dr. Thomas B. Friedman, NIH, Bethesda, MD._Kevin Rice: Assistant Professor of Chemistry, Colby College, Waaterville, ME_. Jong-Moon Kim, Korea
_Aimee Eggler: Research Scientist, University of Illinois at Chicago, IL
_Stephen Abbott: Laboratory Technician, University of Wisconsin-Milwaukee, WI_
Mara Robu: Postdoctoral Fellow with Steve Ekker, University of Minnesota, Minneapolis, MN
_Sergei Saveliev: Senior Scientist II, Proteomics Research & Development, Promega Inc., Madison, WI
_Nami Haruta: Postdoctoral Fellow with Dr. Hiroshi Iwasaki, Graduate School of Integrated Science, Yokohama City University, Japan_Julia Drees:Postdoctoral Fellow with Dr. Alan Wu, University of California, San Francisco_Shelley Lusetti: Assistant Professor, New Mexico State University, Santa Cruz_Michael Hobbs: Scientist, Invitrogen, Madison, WI_Julie Eggington: Postodoctoral Fellow with Dr. Brenda Bass, University of Utah, Salt Lake City, UT_Julia Cox: Patent Scientist, Michael Best & Friedrich LLP, Madison, WI_Dmitry Baytin: Postdoctoral Fellow, Petersburg Nuclear Physics Institute, The Russian Academy of Sciences, St. Petersburg, Russia_Dennis Harris: Postdoctoral Fellow with Dr. Fred Bunz, Johns Hopkins School of Medicine, Baltimore, MD_Akiko Sakasai: Postdoctoral Fellow with Dr. Ichizo Kobayashi, University of Tokyo, Japan_Rachel Britt: Postdoctoral Fellow with Dr. Michael Lieber, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA_Vessela Petrova: Postdoctoral Fellow with Dr. Clay Wang, University of Southern California, Los Angeles, CA_Cedric Norais: Lecturer(Maître de Conférence), Ecole Polytechnique, Paris, France_Marielle Gruenig: Postdoctoral Fellow with Dr. Volker Haucke, Freie Universitat Berlin, Germany_Audrey Klingele: Scientist, Lucigen, Middleton, WI_Khanh Ngo: Postdoctoral Fellow with Dr. Bassem Al-Sady, University of California, San Francisco_Asher Page: Postdoctoral Fellow with Dr. Michael J. Eck, Dana-Farber Cancer Institute_Rose Byrne: Postdoctoral Fellow with Dr. Joaquin M. Espinosa, University of Colorado, Boulder_

Current Teaching Responsibilities: 
Biochemistry 507, fall semester (undergraduate survey course; 150+ students)
Biochemistry 907, spring seminar course
Biochemistry 612, fall semester, 2 lectures_Biochemistry 701, fall semester

Invited Seminars:
 Airlie House Recombination Meeting, VA, November, 1983
_University of Medicine and Dentistry of New Jersey, Newark, NJ, April, 1984_
Cold Spring Harbor Symposium, NY, June, 1984 (2 presentations)
Michigan State University, December, 1984_
Upjohn Corporation, Kalamazoo, MI, December, 1984_
DuPont Inc. Experimental Station, Wilmington, DE, December, 1984_
University of California-Berkeley, Berkeley, CA, March, 1985
_Stanford University, Stanford, CA, March, 1985
_Yeast Recombination Meeting, Cold Spring Harbor, Cold Spring Harbor, NY, March, 1986
_UCLA Symposium on Replication and Recombination, Park City, UT, March, 1986
_Meeting on "Extrachromosomal Elements in Lower Eukaryotes," Urbana, IL, June, 1986_
FASEB Recombination Meeting, VT, July, 1986_
University of Delaware, September, 1986
_Johns Hopkins University, September, 1986_
FASEB Recombinational Meeting, Copper Mountain, CO, July, 1987
_Harvard University, Boston, MA, March, 1988_
Cornell University Medical School, New York, NY, March, 1988_
Cold Spring Harbor Recombination Meeting, NY, September, 1988
_University of South Dakota, December, 1988_
Enzyme Mechanisms Conference, St. Petersburg, FL, January, 1989_
University of Maryland, College Park, MD, March, 1989_
UCLA Symposium on Replication and Recombination, Keystone, CO, March, 1989_
ACS Meeting (Lilly Award Presentation), Dallas, TX, April, 1989_
Gordon Conference, New London, NH, June, 1989_
FASEB Recombination Meeting, Copper Mountain, CO, July, 1989 (Session Chair)_Eli Lilly and Company, Indianapolis, IN, September, 1989_
Mathematical Approaches to DNA, Santa Fe, NM, January 1990_
Recombination and Repair, Cologne, Federal Republic of Germany, March, 1990_
University of California-Berkeley and Stanford University, Berkeley and Stanford, CA, March, 1990_NCI Training Grant Seminar Series, Vanderbilt University, Nashville, TN, March, 1990_Workshop on Site-Specific Recombination and Transposition, Woods Hole, MA, September, 1990_University of Texas Southwestern Medical Center, Dallas, TX, February, 1991_FASEB Recombination Meeting, Saxtons River, VT, July-August, 1991_Washington University School of Medicine, St. Louis, MO, September, 199l_International Conference on Genome Plasticity, Cancun, Mexico, December,1991_UCLA Symposium on Molecular Mechanisms in DNA Replication & Recombination, Taos, NM, January-February, 1992_DNA-Protein Complexes:  Structures and Functions, Austin, TX, April, 1992_University of Nebraska Medical Center, Omaha, NE, May, 1992_Biopolymers Gordon Research Conference, Newport, RI, June, 1992_2nd Site-specific Recombination and Transposition Workshop, Berlin, Germany, September, 1992_Midwest Yeast Club, University of Chicago, Chicago, IL, November, 1992_Midwest Prokaryotic Molecular Genetics and Physiology Club, University of Wisconsin-Madison, Madison, WI, September, 1993_University of Minnesota, Department of Cell Biology and Neuroanatomy, Minneapolis, MN, March, 1994_EMBO Workshop on Genetic Recombination, Seillac, France, June, 1994_University of Wyoming, Department of Molecular Biology, Laramie, WY, October, 1994_The I. Robert Lehman Symposium, Sonoma, CA, November 1994_FASEB Ciliate Molecular Biology Meeting, Copper Mountain, CO, July, 1995_FASEB Genetic Recombination and Genome Rearrangements Meeting, Snowmass Mountain, CO, August, 1995_KEYSTONE Mechanisms of Site-Specific Recombination and Transposition, Taos, NM, February, 1996 (Session Chair)_University of Delaware Spring Seminar, Newark, DE, March, 1996_EMBO Workshop on Genetic Recombination, Seillac, France, May, 1996_ASBMB Satellite Meeting on DNA Repair, New Orleans, LA, June, 1996 (Session Chair)_The Bill Jencks Symposium, Brandeis University, Waltham, MA, July, 1996_Workshop on Site-Specific Recombination and Transposition, Woods Hole, MA, September, 1996_Texas A&M University, College Station, TX, December, 1996_Northern Illinois University, DeKalb, IL, January, 1997_FASEB Ciliate Molecular Biology, Copper Mountain, CO, July, 1997_FASEB Genetic Recombination and Chromosome Rearrangements, Snowmass Mountain, CO, August 1997_Programmed Gene Rearrangement: Site-Specific Recombination, Madrid, Spain, October, 1997_Duke University Seminar, Durham, NC, May, 1998_International Congress of Genetics, Beijing, China, August, 1998_Kyoto University, Kyoto, Japan, August, 1998_KEYSTONE Molecular Mechanisms in DNA Replication and Recombination, Taos, NM, February, 1999_Osaka University, Osaka, Japan, February, 1999_Mechanisms of Homologous Recombination and Genetic Rearrangements, Madrid, Spain, April, 1999_Texas A&M University, Houston, TX, May, 1999_Oregon State University, Corvallis, OR, June, 1999_FASEB Genetic Recombination and Genome Rearrangements, Snowmass, CO, August, 1999_Purdue University, West Lafayette, IN, March, 2000_University of Massachusetts, Amherst, MA, April, 2000_Nucleic Acids Gordon Conference, Newport, RI, June, 2000_National Academy of Sciences Conference on Relationships between Replication and Recombination, Irvine, CA, November, 2000 (Meeting Co-organizer)_University of Wisconsin-Milwaukee, WI, November 2000_University of Texas Health Science Center at San Antonio, TX, December, 2000_KEYSTONE Bacterial Chromosomes, Santa Fe, NM, February 2001_University of Illinois-Champagne Urbana, IL, March 2001_Programmed Gene Rearrangement: Site Specific Recombination, Madrid, Spain, April 2001_Nucleic Acids Gordon Conference, Newport, RI, June, 2001 (Meeting Vice-chair)_Yale University, New Haven, CT, November 2001_KEYSTONE The Interaction of Replication and Recombination, Snowbird, UT, January 2002_Nucleic Acids Gordon Conference, Newport, RI, June 2002 (Meeting Co-Chair)_Mutagenesis and Carcinogenesis Gordon Conference, Ventura, CA, March 2002_University of Cincinnati College of Medicine, Cincinnati, OH, April 2002_Nucleic Acids Gordon Conference, Bristol, RI, June 2002 (Meeting Co-Chair)_University of Alabama-Birmingham, Birmingham, AL, April 2003_FASEB Genetic Recombination and Chromosomal Rearrangements, Snowmass, CO, July 2003_Mutagenesis and Carcinogenesis Gordon Conference, Ventura, CA, March 2004_University of Nebraska Medical Center, Omaha, NB, April 2004_University of California, Los Angeles, CA, May 2004_Yale University School of Medicine, New Haven, CT, September 2004_University of Texas, Austin, TX, November 2004_University of Virginia, Charlottesville, VA, November 2004 NIH, Bethesda, MD, November 2004 Northwestern University, Chicago, IL, December 2004_Brandeis University, Kaplan Lecture, Waltham, MA, April 2005_ASBMB 2005 Annual Meeting, San Diego, CA, April 2005 (Session Chair)_KEYSTONE Nucleic Acid Enzymes, Taos, NM, February 2006 (Meeting Chair)_EMBO Workshop on Recombination Mechanisms, Seillac, France, May 2006_FASEB Summer Research Conference, Saxtons River, VT, June 2006_ Instructor, DNA and Chromosomes: Physical and Biological Approaches, Corsica, France, June 2006_Universität Zuerich-Irchel, Institut für Veterinäbiochemie, Zürich, Switzerland, July 2006_ University of Illinois, Urbana-Champaign, IL, November 2006_McGill University, Montreal-Quebec, Canada, November 2006_Colby College, Waterville, ME, December 2006_FASEB Recombination and chromosomal rearrangements, Snowmass Village, CO, July 2007 (Meeting Co-Chair)_ASBMB Annual Meeting, San Diego, CA, April 2008_University of Paris Sud, Orsay, France, March 2008_FASEB Summer Research Conference, Snowmass Village, CO, August 2009 (Meeting Chair)_Cantoblanco Workshop “Molecular Mechanisms of Genomic Stability”, Madrid, Spain, May 2009_St. Louis University School of Medicine, St. Louis, MO, November 2009_Chemistry Promotion Center, National Taiwan University, February 2010_Portland State University, Portland, OR, April 2010_Louisiana State University, Baton Rouge, LA, April 2010_EMBO Conference on Recombination Mechanisms, Il Ciocco, Italy, May 2010_University of Virginia, Charlottesville, VA, November 2010_KEYSTONE DNA Replication and Recombination, Keystone, CO, February 2011_AAAS 2011 Annual Meeting, Washington, DC, February 2011_ ASBMB 2011 Annual Meeting, Washington DC, April 2011_ The Forensic DNA Symposium, IA, June 2011_FASEB Summer Research Conference, Steamboat Springs, CO, July 2011_EMBO Conference "Recombination Mechanisms", Seville, Spain, May 2012_Green Mountain DNA Conference, Burlington, VT, August 2012_McMaster University, Ontario, Canada, March 2013_FASEB Summer Research Conference, Steamboat Springs, CO, July 2013_Green Mountain DNA Conference, Burlington, VT, August 2013_ASBMB Workshop, Designing Scientific Teaching Tools for Biochemistry and Molecular Biology Education, San Francisco State University, San Francisco, CA, April 2014_ABCAM, Mechanisms of Recombination: 50th Anniversary Meeting, Alicante, Spain, May 2014_

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