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Michael M. Cox - Principal Investigator

Curriculum Vitae

Mailing Address:
Department of Biochemistry
433 Babcock Drive
University of Wisconsin-Madison
Madison, WI 53706-1544

Shipping Address:
Department of Biochemistry
University of Wisconsin-Madison
420 Henry Mall
Madison, WI 53706

Telephone: (608)-262-1181

Fax: (608)-265-2603

Email: cox@biochem.wisc.edu

Assistant:
Carol Pfeffer

Telephone: (608)-263-0858

Email: pfeffer@biochem.wisc.edu

Education and Training: 9/70-6/74 University of Delaware, B.A., Biology 9/74-8/79 Brandeis University, Ph.D., Biochemistry. Thesis advisor: Dr. William P. Jencks. 1979-1982 Postdoctoral Fellow, Department of Biochemistry, Stanford, University School of Medicine, Stanford, CA 94305 (with Dr. I. R. Lehman).

Professional Employment: 1983-1987 Assistant Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706 1987-1992 Associate Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706 1992-present Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706 8/93-present Assistant Chair, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706

Current Research Activity: Studies of the mechanism of action of proteins involved in genetic recombination. Present work is focused on the bacterial RecA protein, the bacterial RecF, RecO, RecR, RecG, RuvA, and RuvB proteins, the yeast Rad51 protein, and more broadly on the mechanism of the recombinational DNA repair of stalled replication forks.

Fellowships and Awards: 9/79-9/81 American Cancer Society Postdoctoral Fellowship 9/81-9/82 Bank of America-Giannini Foundation Postdoctoral Fellowship 7/83-6/88 Shaw Fellowship (research award) awarded by the Milwaukee Foundation 7/84-6/89 National Institutes of Health Research Career Development Award 9/84-9/86 March of Dimes-Basil O'Connor Starter Research Grant (research award) 1986-1991 Dreyfus Teacher-Scholar Award 1989 Eli Lilly Award sponsored by the American Chemical Society, Division of Biological Chemistry 1989 Romnes Faculty Fellowship 1994 Spitzer Teaching Award, University of Wisconsin College of Agriculture and Life Sciences 1998 Vilas Associate Award, University of Wisconsin Graduate School 2000 WARF Kellett Mid-Career Faculty Research Award

National/International Service (excluding routine paper/grant review):

2/88, 6/90, 2/02, 6/03, 10/05, 206, 10/07 NIH Microbial Genetics Study Section (Ad hoc); 7/1/91-1/31/97 Assistant Editor, Journal of Biological Chemistry; 7/92 NIH Special Review Committee Site Visit Review; 1/93-6/95 NIH Microbial Physiology and Genetics Study Section; 1998-2001 Council Member, American Society of Biochemistry and Molecular Biology; 1997-present Chief Advisor in development of the Encyclopedia of Life Sciences/Online Encyclopedia,Nature Publishing Group, UK (launched 2001); 1999-2005 Assistant Editor, Journal of Biological Chemistry; 2001 (November) Organizing Committee, National Academy of Sciences Symposium on Relationships between Replication and Recombination, Irvine, CA; 2002 Meeting co-chair, Nucleic Acids Gordon Conference; 2002-2005 Member, U.S. National Committee for the International Union for Biochemistry and Molecular Biology (USNC/IUBMB); 2002-present Editor, Critical Reviews in Biochemistry and Molecular Biology; 2006 Meeting co-chair, Nucleic Acids Keystone Symposium; 2005-present Editorial Board, BioMed Central Microbiology; 2006-present Advisor, FASEB “Educating About Evolution” Subcommittee; 3/2008 Visiting Professor, University of Paris Sud, Orsay, France

Major Departmental Service (routine committee work excluded): 1986 - present Chair, departmental space and remodeling committee 1992 - present Chair, new buildings committee. Oversaw design and construction of 1998 building (200,000 GSF). Planning begun on 2006 building (250,000 GSF)

Patent: 2007, Michael M. Cox, Dennis R. Harris, Sergei V. Saveliev, Julie M. Eggington, John R. Battista, Edmond Joivet, and Masashi Tanaka. Method to protect DNA Ends. U.S. Patent Number 7,211,393_2007, Michael M. Cox, Shelley Lusetti, Aimee Eggler, and Nami Haruta. RecA Mutants. U.S. Patent Number 7,176,007_ 2000, Michael M. Cox, Elizabeth Wood and Li-chun Huang, Chromosomal targeting in bacteria using FLP recombinase. U.S. Patent Number 6,140,129.

Students and Postdoctoral Fellows in Training:Rachel Britt, graduate student (Biochemistry)_Vessela Petrova, graduate student (CMB)_Marielle Gruenig, graduate student (Biochemistry)_Audrey Klingele, graduate student (Microbiology)_Asher Page, graduate student (Biochemistry)_Khanh Ngo, graduate student (Biochemistry)_Akiko Sakai, postdoctoral fellow_Cedric Norais, postdoctoral fellow

Former Students and Postdoctoral Fellows: Sandra K. Neuendorf: Senior Lecturer, Department of Chemistry, University of Wisconsin-Oshkosh, Oshkosh, WI. Scott W. Morrical: Associate Professor, Department of Biochemistry, University of Vermont, Burlington, VT. Julie F. Senecoff: Masters Program in Genetic counseling at Arcadia University, PA. Robert C. Bruckner: Research Investigator, Sterling Winthrop Inc., Collegeville, PA. B. Frank Pugh: Associate Professor, Department of Molecular and Cellular Biology, The Pennsylvania State University, University Park, PA. Brian C. Schutte: Adjunct Faculty Instructor/Associate Research Scientist, Department of Pediatrics, and Director of the Child Health Research Center Molecular Core Laboratory, University of Iowa, Iowa City, IA. Cynthia Gates: Staff Scientist, Vertex Pharmaceuticals, Cambridge, MA. Leslie Meyer-Leon: Patent Attorney, Goodwin, Procter & Hoar LLP, Boston, MA Janet E. Lindsley: Associate Professor, Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT. Jongwon Lee: Professor, School of Medicine, Taegu Catholic University, Taegu, Korea. Scott Umlauf: Senior Scientist, Powerject Vaccines, Madison, WI. Li-chun Huang: Manager, Corautus Genetics, San Jose, CA. Jong-Il Kim: Research Scientist, Scientific Research Center, Department of Microbiology, Seoul National University, Shilim-Dong, Kwanak-GU, Seoul, Korea Wendy Bedale: Assistant Scientist, Department of Biochemistry, UW-Madison, Madison, WI. Sarita Jain: Associate Director, Corporate and Business Development, PDF Biopharma, Inc., Fremont, CA Koichiro Ishimori: Associate Professor with Dr. Isao Morishim, Kyoto University, Division of Molecular Engineering, Kyoto, Japan Xiao-hong Qian: President, CEO, GenePharm, Sunnyvale, CA. Lisa Iype: Seattle, WA (relocating) (delete relocating). Leslie Waite: Postdoctoral Fellow with Dr. Joanne Engel, University of California, San Francisco, CA. Kerry MacFarland: Professor, Department of Biochemistry, Illinois College, Jacksonville, IL. Brian Webb: Platform Manager, Pierce Biotechnology (ThermoFisher).Alberto Roca: Postdoctoral Fellow, University of California, Los Angeles, CA. Paul Marrione: Staff Scientist, PPD Development, Madison, WI. Natalie Baker: Science Coordinator, Elementary School located near Grant Rapids, MI. Qun Shan: Postdoctoral Fellow with Dr. Jasper Rine, University of California, Berkeley, CA. Tanya Arenson: Staff Scientist, Medlen & Carroll, LLP, Madison, WI. Julie Bork: Postdoctoral Fellow with Dr. Thomas B. Friedman, NIH, Bethesda, MD. Kevin Rice: Assistant Professor of Chemistry, Colby College . Jong-Moon Kim, Korea Aimee Eggler: Research Scientist, University of Illinois at Chicago, IL Stephen Abbott, Laboratory Technician, University of Wisconsin-Milwaukee, WI Mara Robu: Postdoctoral Fellow with Steve Ekker, University of Minnesota, Minneapolis, MN Sergei Saveliev: Senior Scientist II, Proteomics Research & Development, Promega Inc., Madison, WI Nami Haruta: Postdoctoral Fellow with Dr. Hiroshi Iwasaki, Graduate School of Integrated Science, Yokohama City University, Japan_Julia Drees:Postdoctoral Fellow with Dr. Alan Wu, University of California, San Francisco_Shelley Lusetti: Assistant Professor, New Mexico State University, Santa Cruz_Michael Hobbs, Scientist, Invitrogen, Madison, WI_Julie Eggington: Postodoctoral Fellow with Dr. Brenda Bass, University of Utah, Salt Lake City, UT_Julia Cox: Patent Scientist, Michael Best & Friedrich LLP, Madison, WI_Dmitry Baytin: Postdoctoral Fellow with Vladislav Lanzov, Petersburg Nuclear Physics Institute, The Russian Academy of Sciences, Dennis Harris: Postdoctoral Fellow with Miro Radman, Institut National de la Sante et de la Recherche Medical (INSERM)

Current Teaching Responsibilities: Biochemistry 507, fall semester (undergraduate survey course; 150+ students) Biochemistry 907, spring seminar course Biochemistry 612, fall semester, 2 lectures_Biochemistry 701, fall semester

Invited Seminars: Airlie House Recombination Meeting, VA, November, 1983 University of Medicine and Dentistry of New Jersey, Newark, NJ, April, 1984 Cold Spring Harbor Symposium, NY, June, 1984 (2 presentations) Michigan State University, December, 1984 Upjohn Corporation, Kalamazoo, MI, December, 1984 DuPont Inc. Experimental Station, Wilmington, DE, December, 1984 University of California-Berkeley, Berkeley, CA, March, 1985 Stanford University, Stanford, CA, March, 1985 Yeast Recombination Meeting, Cold Spring Harbor, Cold Spring Harbor, NY, March, 1986 UCLA Symposium on Replication and Recombination, Park City, UT, March, 1986 Meeting on "Extrachromosomal Elements in Lower Eukaryotes," Urbana, IL, June, 1986 FASEB Recombination Meeting, VT, July, 1986 University of Delaware, September, 1986 Johns Hopkins University, September, 1986 FASEB Recombinational Meeting, Copper Mountain, CO, July, 1987 Harvard University, Boston, MA, March, 1988 Cornell University Medical School, New York, NY, March, 1988 Cold Spring Harbor Recombination Meeting, NY, September, 1988 University of South Dakota, December, 1988 Enzyme Mechanisms Conference, St. Petersburg, FL, January, 1989 University of Maryland, College Park, MD, March, 1989 UCLA Symposium on Replication and Recombination, Keystone, CO, March, 1989 ACS Meeting (Lilly Award Presentation), Dallas, TX, April, 1989 Gordon Conference, New London, NH, June, 1989 FASEB Recombination Meeting, Copper Mountain, CO, July, 1989 (Session Chair) Eli Lilly and Company, Indianapolis, IN, September, 1989 Mathematical Approaches to DNA, Santa Fe, NM, January 1990 Recombination and Repair, Cologne, Federal Republic of Germany, March, 1990 University of California-Berkeley and Stanford University, Berkeley and Stanford, CA, March, 1990 NCI Training Grant Seminar Series, Vanderbilt University, Nashville, TN, March, 1990 Workshop on Site-Specific Recombination and Transposition, Woods Hole, MA, September, 1990 University of Texas Southwestern Medical Center, Dallas, TX, February, 1991 FASEB Recombination Meeting, Saxtons River, VT, July-August, 1991 Washington University School of Medicine, St. Louis, MO, September, 199l International Conference on Genome Plasticity, Cancun, Mexico, December,1991 UCLA Symposium on Molecular Mechanisms in DNA Replication & Recombination, Taos, NM, January-February, 1992 DNA-Protein Complexes: Structures and Functions, Austin, TX, April, 1992 University of Nebraska Medical Center, Omaha, NE, May, 1992 Biopolymers Gordon Research Conference, Newport, RI, June, 1992 2nd Site-specific Recombination and Transposition Workshop, Berlin, Germany, September, 1992 Midwest Yeast Club, University of Chicago, Chicago, IL, November, 1992 Midwest Prokaryotic Molecular Genetics and Physiology Club, University of Wisconsin-Madison, Madison, WI, September, 1993 University of Minnesota, Department of Cell Biology and Neuroanatomy, Minneapolis, MN, March, 1994 EMBO Workshop on Genetic Recombination, Seillac, France, June, 1994 University of Wyoming, Department of Molecular Biology, Laramie, WY, October, 1994 The I. Robert Lehman Symposium, Sonoma, CA, November 1994 FASEB Ciliate Molecular Biology Meeting, Copper Mountain, CO, July, 1995 FASEB Genetic Recombination and Genome Rearrangements Meeting, Snowmass Mountain, CO, August, 1995. KEYSTONE Mechanisms of Site-Specific Recombination and Transposition, Taos, NM, February, 1996 (Session Chair) University of Delaware Spring Seminar, Newark, DE, March, 1996. EMBO Workshop on Genetic Recombination, Seillac, France, May, 1996 ASBMB Satellite Meeting on DNA Repair, New Orleans, LA, June, 1996 (Session Chair) The Bill Jencks Symposium, Brandeis University, Waltham, MA, July, 1996 1996 Workshop on Site-Specific Recombination and Transposition, Woods Hole, MA, September, 1996 Texas A&M University, College Station, TX, December, 1996 Northern Illinois University, DeKalb, IL, January, 1997 FASEB Ciliate Molecular Biology, Copper Mountain, CO, July, 1997 FASEB Genetic Recombination and Chromosome Rearrangements, Snowmass Mountain, CO, August 1997 Programmed Gene Rearrangement: Site-Specific Recombination, Madrid, Spain, October, 1997 Duke University Seminar, Durham, NC, May, 1998 International Congress of Genetics, Beijing, China, August, 1998 Kyoto University, Kyoto, Japan, August, 1998 KEYSTONE Molecular Mechanisms in DNA Replication and Recombination, Taos, NM, February, 1999 Osaka University, Osaka, Japan, February, 1999 Mechanisms of Homologous Recombination and Genetic Rearrangements, Madrid, Spain, April, 1999 Texas A&M University, Houston, TX, May, 1999 Oregon State University, Corvallis, OR, June, 1999 FASEB Genetic Recombination and Genome Rearrangements, Snowmass, CO, August, 1999 Purdue University, West Lafayette, IN, March, 2000 University of Massachusetts, Amherst, MA, April, 2000 Nucleic Acids Gordon Conference, Newport, RI, June, 2000 National Academy of Sciences Conference on Relationships between Replication and Recombination, Irvine, CA, November, 2000 (Meeting Co-organizer) University of Wisconsin-Milwaukee, WI, November 2000 University of Texas Health Science Center at San Antonio, TX, December, 2000 KEYSTONE Bacterial Chromosomes, Santa Fe, NM, February 2001 University of Illinois-Champagne Urbana, IL, March 2001 Programmed Gene Rearrangement: Site Specific Recombination, Madrid, Spain, April 2001 Nucleic Acids Gordon Conference, Newport, RI, June, 2001 (Meeting Vice-chair) Yale University, New Haven, CT, November 2001 KEYSTONE The Interaction of Replication and Recombination, Snowbird, UT, January 2002 Nucleic Acids Gordon Conference, Newport, RI, June 2002 (Meeting Co-Chair) Mutagenesis and Carcinogenesis Gordon Conference, Ventura, CA, March 2002 University of Cincinnati College of Medicine, Cincinnati, OH, April 2002 Nucleic Acids Gordon Conference, Bristol, RI, June 2002 (Meeting Co-Chair) University of Alabama-Birmingham, Birmingham, AL, April 2003 FASEB Genetic Recombination and Chromosomal Rearrangements, Snowmass, CO, July 2003 Mutagenesis and Carcinogenesis Gordon Conference, Ventura, CA, March 2004 University of Nebraska Medical Center, Omaha, NB, April 2004 University of California, Los Angeles, CA, May 2004 Yale University School of Medicine, New Haven, CT, September 2004 University of Texas, Austin, TX, November 2004 University of Virginia, Charlottesville, VA, November 2004 NIH, Bethesda, MD, November 2004 Northwestern University, Chicago, IL, December 2004 Brandeis University, Kaplan Lecture, Waltham, MA, April 2005 ASBMB 2005 Annual Meeting, San Diego, CA, April 2005 (Session Chair) KEYSTONE Nucleic Acid Enzymes, Taos, NM, February 2006 (Meeting Chair)_EMBO Workshop on Recombination Mechanisms, Seillac, France, May 2006_FASEB Summer Research Conference, Saxtons River, VT, June 2006_ Instructor, DNA and Chromosomes: Physical and Biological Approaches, Corsica, France, June 2006_Universität Zuerich-Irchel, Institut für Veterinäbiochemie, Zürich, Switzerland, July 2006_ University of Illinois, Urbana-Champaign, IL, November 2006_McGill University, Montreal-Quebec, Canada, November 2006_Colby college, Waterville, ME, December 2006_FASEB Recombination and chromosomal rearrangements, Snowmass Village, CO, July 2007 (Meeting Co-Chair)_ASBMB Annual Meeting, San Diego, CA, April 2008_University of Paris Sud, Orsay, France, March 2008_FASEB, 2009 (Meeting Chair)

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