Musah S, Wrighton PJ, Zaltsman Y, Zhong X, Zorn S, Parlato, MB, Hsiao C, Palecek SP, Chang Q, Murphy WL, Kiessling LL. Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proc Nat Acad Sci USA. Epub 2014 Sept 8. 

Sheridan RT, Hudon J, Hank JA, Sondel PM, Kiessling LL. Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells. Chembiochem. 2014 Jul 7;15(10):1393-8.

Martinez Farias MA, Kincaid VA, Annamalai VR, Kiessling LL. Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates. J Am Chem Soc. 2014 Jun 18;136(24):8492-5.

Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ. New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. 2014 Mar 18;53(10):1575-85.

Courtney AH, Bennett NR, Zwick DB, Hudon J, Kiessling LL. Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling. ACS Chem Biol. 2014 Jan 17;9(1):202-10.


Kiessling LL, Kraft MB. Chemistry. A path to complex carbohydrates. Science. 2013 Jul 26;341(6144):357-8.

Wesener DA, May JF, Huffman EM, Kiessling LL. UDP-Galactopyranose Mutase in Nematodes; Biochemistry. 2013 Jun 25;52(25):4391-8.link to pdf file

Kiessling LL, Grim JC. Glycopolymer probes of signal transduction. Chem Soc Rev. 2013 May 21;42(10):4476-91.link to pdf file

Fishman JM, Kiessling LL. Synthesis of functionalizable and degradable polymers by ring-opening metathesis polymerization.;Angew Chem Int Ed Engl. 2013 May 3;52(19):5061-4.link to pdf file

Kraft MB, Martinez Farias MA, Kiessling LL. Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases.J Org Chem. 2013 Mar 1;78(5):2128-33.link to pdf file


Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S, Kiessling LL. Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano. 2012 Nov 27;6(11):10168-77.link to pdf file

Kiessling LL. Recasting Biomolecules for Function. ACS Chem Biol. 2012 Jan 20;7(1):1-2. link to pdf file

Prost LR, Grim JS, Tonelli M, Kiessling LL. Non-Carbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists. ACS Chem Biol. 2012 Jul 19link to pdf file

Brown CD, Rusek MS, Kiessling LL. Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase. J Am Chem Soc. 2012 Apr 18;134(15):6552-5. Epub 2012 Apr 10.link to pdf file

Mangold SL, Prost LR, Kiessling LL. Quinoxalinone Inhibitors of the Lectin DC-SIGN. Chem Sci. 2012 Mar;3(3):772-777. Epub 2011 Nov. 24. link to pdf file

Wong ML, Guzei IA, Kiessling LL. An Asymmetric Synthesis of l-Pyrrolysine. . 2012 Mar 16;14(6):1378-81. Epub 2012 Mar 6. link to pdf file

May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL. A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site. Biochemistry. 2012 Feb 14;51(6):1148-59. Epub 2012 Feb 3. link to pdf file

Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RT, Wong ML, Kiessling LL. Small-Molecule-Modified Surfaces Engage Cells through the α(v)β(3) Integrin. ACS Chem Biol. 2012 Mar 16;7(3):518-25. Epub 2012 Jan 26. link to pdf file


Levengood MR, Splain RA, Kiessling LL. Monitoring Processivity and Length Control of a Carbohydrate Polymerase. J Am Chem Soc. 2011 Jul 25 Epub.link to pdf file

Li L, Klim JR, Derda R, Courtney AH, Kiessling LL (2011) Spatial control of cell fate using synthetic surfaces to potentiate TGF-B signaling. Proc Natl Acad Sci USA. 108(29):11745-50. Epub 2011 Jun 30 link to pdf file

Grim JC, Garber KC, Kiessling LL (2011) Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid. Org. Lett. 2011 Jun 28 Epublink to pdf file

Underbakke ES, Zhu Y, Kiessling LL (2011) Protein Footprinting in a Comples Milieu: Identifying the Interaction Surfaces of the Chemotaxis Adaptor Protein CheW. J Mol Biol.409(4):483-95link to pdf file


Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL (2010) A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods. 7(12):989-94link to pdf file

Underbakke ES, Kiessling LL (2010) Classifying chemoreceptors: quantity versus quality. EMBO J. 29(20):3435-6link to pdf file

Li L, Orner BP, Huang T, Hinck AP, Kiessling LL (2010) Peptide ligands that use a novel site to target both TGF-beta receptors. Mol Biosyst. 6(12):2392-402link to pdf file

Garber KC, Wangkanont K, Carlson EE, Kiessling LL (2010) A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN. Chem Commun (Camb). 46(36):6747-9link to pdf file

Jiarpinitnum C, Kiessling LL (2010) Unexpected enhancement in biological activity of a GPCR ligand induced by a n oligoethylene glycol substitute. J Am Chem Soc. 132(26):8844-5 link to pdf file

Splain RA, Kiessling LL (2010) Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2. Bioorg Med Chem. 18(11):3753-9 link to pdf file

Kiessling LL, Splain RA (2010) Chemical approaches to glycobiology. Annu Rev Biochem 79:619-53 link to pdf file

Kiessling LL. (2010) Decoding signals with chemical biology. ACS Chem Biol. 5(1):1-2 link to pdf file

Derda R, Musah S, Orner BP, Klim JR, Li L, Kiessling LL. (2010) High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. J Am Chem Soc. 132(4):1289-95link to pdf file


Gruber TD, Westler WM, Kiessling LL, Forest KT (2009) X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin. Biochemistry. 48(39):9171-3 link to pdf file

Lamanna AC, Kiessling LL (2009) Flow cytometry reveals that multivalent chemoattractants effect swarmer cell dedifferentiation. ACS Chem Biol. 4(10):828-33 link to pdf file

May JF, Kiessling LL (2009) A tethering mechanism for length control in a processive carbohydrate polymerization. Proc Natl Acad Sci USA 106(29):11851-11856 link to pdf file

Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. (2009) Ligand binding and substrate discrimination by UDP-Galactopyranose mutase. J Mol Biol. 391(2):327-340link to pdf file

Kolonko EM, Pontrello JK, Mangold SL, Kiessling LL. (2009) General synthetic route to cell-permeable block copolymers via ROMP. J Am Chem Soc. 131(21):7327-7333 link to pdf file

Dykhuizen EC, Kiessling LL. (2009) Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite. Org Lett. 11(1):193-196link to pdf file

Courtney AH, Puffer EB, Pontrello JK, Yang ZQ Kiessling LL. (2009) Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation. Proc Natl Acad Sci USA 106(8):2500-2505link to pdf file

Borrok MJ, Zhu Y, Forest KT, Kiessling LL. (2009) Structure-based design of a periplasmic binding protein antagonist that prevents domain closure. ACS Chem Biol. 4(6):447-456 link to pdf file

Allen MJ, Wangkanont K, Raines RT, Kiessling, LL. (2009) ROMP from ROMP: A new approach to graft copolymer synthesis. Macromolecules. 42(12):4023-4027 link to pdf file


Underbakke ES, Zhu Y, Kiessling LL. (2008) Isotope-coded affinity tags with tunable reactivities for protein footprinting. Angew Chem, Int Ed. 47(50):9677-9680 link to pdf file

Mangold SL, Carpenter RT, Kiessling LL. (2008) Synthesis of fluorogenic polymers for visualizing cellular internalization. Org Lett. 10(14):2997-3000. PMID: 18563907 2006AllenJACS.pdf

Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008) Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. J Am Chem Soc. 130(21):6706-7. PMID: 18447352 link to pdf file

Kolonko EM, Kiessling LL. (2008) A polymeric domain that promotes cellular internalization.
J Am Chem Soc. 130(17):5626-7. PMID: 18393495 link to pdf file

Borrok MJ, Kolonko EM, Kiessling LL. (2008) Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array.
ACS Chem Biol. 3(2):101-9. PMID: 18278851 link to pdf file


Borrok MJ, Kiessling LL. (2007) Non-carbohydrate inhibitors of the lectin DC-SIGN.
J Am Chem Soc. 129(42):12780-5. PMID: 17902657 link to pdf file

Derda R, Wherritt DJ, Kiessling LL. (2007) Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers. Langmuir. 23(22):11164-7. PMID: 17880250 link to pdf file

Chad JM, Sarathy KP, Gruber TD, Addala E, Kiessling LL, Sanders DA.(2007) Site-directed mutagenesis of UDP-galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues. Biochemistry. 46(23):6723-32. PMID: 17511471link to pdf file

Borrok MJ, Kiessling LL, Forest KT. (2007) Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
Protein Sci. 16(6):1032-41. PMID: 17473016 link to pdf file

Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol. 2(5):347-55. PMID: 17480050 link to pdf file

Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. (2007) A higher degree of difficulty. ACS Chem Biol. 2(4):197-9. No abstract available. PMID: 17455890 link to pdf file

Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL. (2007) Activating B cell signaling with defined multivalent ligands. ACS Chem Biol. 2(4):252-62. PMID: 17432821 link to pdf file

Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. (2007) Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chem Biol. 2(2):119-27. PMID: 17291050link to pdf file

Owen, R.M., Carlson, C.B., Xu, J., Mowery, P., Fasella, E., and Kiessling, L.L. (2007) Bifunctional Ligands that Target Cells Displaying the ?v?3 Integrin, ChemBioChem, 8, 68 82. 2006AllenJACS.pdf

Carlson, C.B., Mowery, P., Owen, R.M., Dykhuizen, E,C,. and Kiessling, L.L (2007) Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions, ACS Chemical Biology, Vol.2 No. 2, 119. 2006AllenJACS.pdf


Kiessling, L.L., Wedde, S.G., and Ronald T. Raines (2006) Symbiosis: Chemical Biology at Wisconsin, ACS Chemical Biology, Vol.1 No. 8, 481. 2006AllenJACS.pdf

Kiessling, L.L., Gestwicki, J.E. and Strong, L.E. (2006) Synthetic Multivalent Ligands as Probes of Signal Transduction, Angew. Chem. Int. Ed., 45, 2348 2368. 2006AllenJACS.pdf

Orner B. P., Liu L., Murphy R.M., and Kiessling L.L. (2006) Phage Display Affords Peptides that Modulate ?-Amyloid Aggregation, J. Am. Chem. Soc., 128, 11882-11889. 2006AllenJACS.pdf

Carlson, E. E., May, J. F., and Kiessling, L. L. (2006) Chemical probes of UDP-galactopyranose mutase, Chem Biol. 13, 825-837. 2006AllenJACS.pdf

Kiessling, L. L. (2006) Fostering major breakthroughs, ACS Chem. Biol. 1, 1-2. 2006AllenJACS.pdf

He, Y., Wilkins, J. P., and Kiessling, L. L. (2006) N-acylsulfonamide linker activation by Pd-catalyzed allylation, Org. Lett. 8, 2483-2485. 2006AllenJACS.pdf

Allen, M. J., Raines, R. T., and Kiessling, L. L. (2006) Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization, J. Am. Chem. Soc. 128, 6534-6535. 2006AllenJACS.pdf


Pontrello, J.K., Allen, M.J., Underbakke, E,S, and Kiessling, L.L. (2005) Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization, J. Am. Chem. Soc., 127, 14536-14537. 2005BorrokES&T.pdf

Borrok, D., Borrok, M. J., Fein, J. B., and Kiessling, L. L. (2005) Link between chemotactic response to Ni2+ and its adsorption onto the Escherichia coli cell surface, Environ. Sci. Technol. 39, 5227-5233. 2005BorrokES&T.pdf

Lamanna, A. C., Ordal, G. W., and Kiessling, L. L. (2005) Large increases in attractant concentration disrupt the polar localization of bacterial chemoreceptors, Mol. Microbiol. 57, 774-785. 2004.Soltero.NSMB

Soltero-Higgin, M., Carlson, E.E., Phillips, J.H. and Kiessling, L.L. (2005) Identification of Inhibitors for UDP-Galactopyranose Mutase, J. Am. Chem. Soc., 126, 10532-10533. 2006AllenJACS.pdf


He, Y., Hinklin, R.J., Chang, J. and Kiessling, L.L. (2004) Stereoselective N-Glycosylation by Staudinger Ligation, Organic Letters, Vol. 6, No. 24, 4479-4482. 2006AllenJACS.pdf

Orner, B.P., Derda, R., Lewis, R.L., Thomson, J.A., and Kiessling, L.L. (2004) Arrays for the Combinatorial Exploration of Cell Adhesion, J. Am. Chem. Soc., 126, 10808-10809. 2004.Soltero.NSMB

Soltero-Higgin, M. L., Carlson, E. E., Gruber, T. D., and Kiessling, L. L. (2004) A unique catalytic mechanism for UDP-galactopyranose mutase, Nature Mol.Struct. Biol. 11, 539-543. 2004.Soltero.NSMB

Mowery, P., Yang, Z. Q., Gordon, E. J., Dwir, O., Spencer, A. G., Alon, R., and Kiessling, L. L. (2004) Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding, Chem. Biol. 11, 725-732. 2004.Mowery.ChemBio

Carlson, E. E. and Kiessling, L. L. (2004) Improved chemical synthesis of 1- and 5-Deazariboflavin, J. Org. Chem. 69, 2614-2617. 2004.Carlson.JOC

Griffith, B. R., Allen, B. L., Rapraeger, A. C., and Kiessling, L. L. (2004) A polymer scaffold for protein oligomerization, J. Am. Chem. Soc. 126, 1608-1609. 2004.Griffith.JACS


Smith, E. A., Thomas, W. D., Kiessling, L. L., and Corn, R. M. (2003) Surface plasmon resonance imaging studies of protein carbohydrate interactions, J. Am. Chem. Soc. 125, 6140-6148. 2003.Smith.JACS

Schuster, M. C., Mann, D. A., Buchholtz, T. J., Johnson, K. M., and Kiessling, L. L. (2003) Parallel synthesis of glycomimetic libraries that target a C-type lectin, Org. Lett. 5 , 1407-1410. 2003.Schuster.OrgLtr

Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Kiessling, L. L., Yang, Z. Q., Rosen, S. D., and Fisher, S. J. (2003) Trophoblast L-selectin mediates adhesive interactions at the human maternal fetal interface, Science 299, 405-408. link to pdf file


Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., and Kiessling, L. L. (2002) Influencing receptor ligand binding mechanisms with multivalent ligand architecture, J. Am. Chem. Soc. 124, 14922-14933. link to pdf file

Yang, Z. Q., Puffer, E. B., Pontrello, J. K., and Kiessling, L. L. (2002) Synthesis of a multivalent display of a CD22-binding trisaccharide, Carbohydrate Res. 337, 1605-1613. link to pdf file

Young, T. and Kiessling, L. L. (2002) A strategy for the synthesis of sulfated peptides, Angew. Chem. Int. Ed. Eng. 41, 3449-3451. link to pdf file

Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., and Kiessling, L. L. (2002) Conserved amplification of chemotactic responses through chemoreceptor interactions, J. Bacteriol. 184, 4981-4987. link to pdf file

Cairo, C. W., Strzelec, A., Murphy, R. M., and Kiessling, L. L. (2002) Affinity-based inhibition of ?-amyloid toxicity, Biochemistry 41, 8620-8629. link to pdf file

Owen, R. W., Gestwicki, J. E., Young, T., and Kiessling, L. L. (2002) Synthesis and applications of end-labeled neoglycopolymers, Org. Lett. 4, 2293-2296. link to pdf file

Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., and Kiessling, L. L. (2002) Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy, Anal. Biochem. 305, 149-155. link to pdf file

Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., and Kiessling, L. L. (2002) Cell aggregation by scaffolded receptor clusters, Chem. Biol. 9, 163-169. link to pdf file

Cairo, C. W., Gestwicki, J. E., Kanai, M., and Kiessling, L. L. (2002) Control of multivalent interactions by binding epitope density, J. Am. Chem. Soc. 124, 1615-1619. link to pdf file

Kiessling, L. L. and Cairo, C. W. (2002) Hitting the sweet spot, Nature Biotech. 20, 234-235. link to pdf file

Gestwicki, J. E. and Kiessling, L. L. (2002) Inter-receptor communication through arrays of bacterial chemoreceptors, Nature 415, 81-84. link to pdf file

Hinklin, R. J. and Kiessling, L. L. (2002) Para-methoxybenzyl ether cleavage by polymer-supported sulfonamides, Org. Lett. 4, 1131-1133. link to pdf file


Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., and Kiessling, L. L. (2001) Designed potent multivalent chemoattractants for Escherichia coli, Bioorg. Med. Chem. 9, 2387-2393. link to pdf file

Marlow, A. L. and Kiessling, L. L. (2001) Improved chemical synthesis of UDP-galactofuranose, Org. Lett. 3, 2517-2519. link to pdf file

Lowe, T. L., Strzelec, A., Kiessling, L. L., and Murphy, R. M. (2001) Structure-function relationships for Inhibitors of b-amyloid toxicity containing the recognition sequence KLFVV, Biochemistry 40, 7882-7889. link to pdf file

Hinklin, R. J. and Kiessling, L. L. (2001) Glycosyl sulfonylcarbamates: New glycosyl donors with tunable reactivity, J. Am. Chem. Soc. 123, 3379-80. link to pdf file

Nilsson, B. L., Kiessling, L. L., and Raines, R. T. (2001) High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide, Org. Lett. 3, 9-12. link to pdf file

Bertozzi, C. R. and Kiessling, L. L. (2001) Chemical glyobiology, Science 291, 2357-2364. link to pdf file

Kiessling, L. L. (2001) The Periodic Table, Chem. Eng. News 79, 246.

Steinmann, J. G., Phillips, J. H., Sanders, W. J., and Kiessling, L. L. (2001) Synthesis of cyclic sulfates by halocyclization, Org. Lett. 3, 3557-3559. link to pdf file


Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Visualization of single multivalent receptor-liggand complexes by transmission electron microscopy, Angew. Chem. Int. Ed. Eng. 39, 4567-4570. link to pdf file

Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., and Adler, J. (2000) Evolutionary conservation of methyl-accepting chemotaxis protein location in bacteria and archea, J. Bacteriol. 182, 6499-6502. link to pdf file

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Tuning chemotactic responses with synthetic multivalent ligands, Chem. Biol. 7, 583-591. link to pdf file

Nilsson, B. L., Kiessling, L. L, and Raines, R. T. (2000). Staudinger ligation: A peptide from a thioester and azide, Org. Lett. 2, 1939-1941. link to pdf file

Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L. and Adler, J. (2000) Motility and chemotaxis of filamentous cells of Escherichia coli, J. Bacteriol. 182, 4337-4342. link to pdf file

Burke, S. D., Zhao, Q., Schuster, M. C., and Kiessling, L. L. (2000) Synergistic formation of soluble lectin clusters by a templated multivalent saccharide ligand, J. Am. Chem. Soc. 122, 4518-4519. link to pdf file

Gordon, E. J., Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Synthesis of end-labeled multivalent ligands for exploring cell surface receptor ligand interactions, Chem. Biol. 7, 9-16. link to pdf file

Kiessling, L. L., Gestwicki, J. E., and Strong, L. E. (2000) Synthetic multivalent ligands in the exploration of cell surface interactions, Curr. Opin. Chem. Biol. 4, 696-703. link to pdf file

Kiessling, L. L, Strong, L. E., and Gestwicki, J. E. (2000) Principles for multivalent ligand design. Annu. Reports Med. Chem 35, 321-330. link to pdf file


Pohl, N. L. and Kiessling, L. L. (1999) Scope of multivalent ligand function: Lactose-bearing neoglycopolymers by ring-opening metathesis polymerization, Synthesis SI, 1515-1519. link to pdf file

Strong, L. E. and Kiessling, L. L. (1999) A general synthetic route to defined, biologically active multivalent arrays, J. Am. Chem. Soc. 121, 6193-6196. link to pdf file

Pallitto, M. M., Ghanta, J., Heinzelman, P., Kiessling, L. L., and Murphy, R. M. (1999) Recognition sequence design for peptidyl modulators of b-amyloid aggregation and toxicity, Biochemistry 38, 3570-3578. link to pdf file

Sanders, W. J., Gordon, E. J., Dwir, O., Beck, P. J., Alon, R. T., and Kiessling, L. L. (1999) Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics, J. Biol. Chem. 274, 5271-5278. link to pdf file

Kiessling, L. L., DeGrado, W. F., and Ecstein, F. (1999) Modulation of nucleic acids, carbohydrates and proteins to different task, Curr. Opin. Chem. Biol. 3(6), 641-642. link to pdf file


Mann, D. A., Kanai, M., Maly, D. J., and Kiessling, L. L. (1998) Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for Concanavalin A, J. Am. Chem. Soc. 120, 10375-10383. link to pdf file

Gordon, E. J., Strong, L. E., and Kiessling, L. L. (1998) Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin, Bioorg. Med. Chem. 6, 1293-1299. link to pdf file

Gordon, E. J., Sanders, W. J., and Kiessling, L. L. (1998) Synthetic ligands point to cell surface strategies, Nature 392, 30-31. link to pdf file

Kiessling, L. L. and Gordon, E. J. (1998) Transforming the extracellular environment through proteolysis, Chemistry & Biology 5, R49-62. link to pdf file


Sanders, W. J., Manning, D. D., Koeller, K., and Kiessling, L. L. (1997) Synthesis of sulfated trisaccharide ligands for the selectins, Tetrahedron Symposium in Print: Synthetic Methods 53, 16391-16422. link to pdf file

Kanai, M., Mortell, K. H., and Kiessling, L. L. (1997) Varying the size of multivalent ligands: The dependence of Concanavalin A inhibition on neoglycopolymer length, J. Am. Chem. Soc. 119, 9931-9932. link to pdf file

Pohl, N. L. and Kiessling, L. L. (1997) Para-chloro benzyl groups as stabilizers of the glycosidic linkage, Tetrahedron Lett. 38, 6985-6988. link to pdf file

Manning, D. D., Strong, L. E., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Neoglycopolymer inhibitors of the selectins, Tetrahedron Symposium in Print: Bioorg. Chem. 53, 11937-11952.

Manning, D. D., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Synthesis of sulfated neogly-copolymers: Selective P-selectin inhibitors, J. Am. Chem. Soc. 119, 3161-3162. link to pdf file

Kurutz, J. K. and Kiessling, L. L. (1997) Solution conformation of Lewis a-derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions, Glycobiol. 7, 337-347. link to pdf file

Hegg, E., Deal, K., Kiessling, L. L, and Burstyn, J. N. (1997) Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper (II) macrocycle Cu([9]aneN3)Cl2, Inorg. Chem. 36, 1715-1718. link to pdf file

Schuster, M. C., Mortell, K. H., Hegeman, A. D., and Kiessling, L. L. (1997) Neoglycopolymers produced by ring-opening metathesis polymerization: Decreasing saccharide density increases activity, J. Mol. Cat. A: Chemical 116, 209-216. link to pdf file


Schueller, C. M., Manning, D. D., and Kiessling, L. L. (1996) Preparation of R-(+)-7-oxabicyclo[2.2.1]hept-5-ene-exo-2-carboxylic acid, a precursor to substrates for the ring opening metathesis polymerization, Tetrahedron Lett. 37, 8853-8856. link to pdf file

Dantzman, C. L. and Kiessling, L. L. (1996) Reactivity of a 2' thio nucleotide analog, J. Am. Chem. Soc. 118, 11715-11719. link to pdf file

Ghanta, J., Shen, C.-L., Kiessling, L. L., and Murphy, R.M. (1996) A strategy for designing inhibitors of ?-amyloid toxicity, J. Biol. Chem. 271, 29525-29528. link to pdf file

Sanders, W. J., Katsumoto, T. R., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) L-selectin carbohydrate onteractions: Relevant modifications of the Lewis x trisaccharide, Biochemistry 35, 14862-14867. link to pdf file

Brüning, J. and Kiessling, L. L. (1996) Convergent synthesis of sulfated bivalent glycopeptides as selectin ligands, Tetrahedron Lett. 37, 2907-2910. link to pdf file

Manning, D. D., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) Tin-mediated phosphorylation: Synthesis and selectin binding of a phospho Lewis a analog, Tetrahedron Lett. 37, 1953-1956. link to pdf file

Mortell, K. H., Weatherman, R. V., and Kiessling, L. L. (1996) Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization, J. Am. Chem. Soc. 118, 2297-2298. link to pdf file

Weatherman, R. V., Mortell, K. H., Chervenak, M., Kiessling, L. L., and Toone, E. J. (1996) Specificity of C-Glycoside complexation by mannose/glucose specific lectins, Biochemistry 35, 3619-3624.link to pdf file

Weatherman, R. V. and Kiessling, L. L. (1996) Fluorescence anisotropy assays reveal affinities of C- and O-Glycosides for Concanavalin A, J. Org. Chem. 61, 534-538.link to pdf file

Kiessling, L. L. and Pohl, N. L. (1996) Strength in numbers: Non-natural polyvalent carbohydrate derivatives, Chemistry & Biology 3, 71-77. link to pdf file


Kiessling, L. L. (1995) Creating molecules: Evolution of randomness. Graven Images 2, 222-228. link to pdf file

Manning, D. D., Bertozzi, C. R., Pohl, N. L., Rosen, S. D., and Kiessling, L. L. (1995) Selectin saccharide interactions: Revealing structure function relationships with chemical synthesis, J. Org. Chem. 60, 6254-6255. link to pdf file


Mortell, K. H., Gingras, M., and Kiessling, L. L. (1994) Synthesis of cell agglutination inhibitors by aqueous ring-opening metathesis polymerization, J. Am. Chem. Soc. 116, 12053-12054. link to pdf file

Sanders, W. and Kiessling, L. L. (1994) Stereoselective Lewis acid-catalyzed glycosylation of cyclic sulfites, Tetrahedron Lett. 35, 7335-7338. link to pdf file


Griffin, L. C., Kiessling, L. L, Beal, P. A., Gillespie, P., and Dervan, P. B. (1992) Recognition of all four base pairs of double helical DNA by triple helix formation: Design of non-natural deoxyribonucleosides for pyrimidine-purine base pair binding, J. Am. Chem. Soc. 114, 7976-7982. link to pdf file

Kiessling, L. L., Griffin, L. C., and Dervan, P. B. (1992) Flanking sequence effects within the pyrimidine triple helix motif characterized by affinity cleaving, Biochemistry 31, 2829-2834. link to pdf file


Hawley, R. C., Kiessling, L. L., Schreiber, S. L. (1989) Model of the interactions of calichemicin g1 with a DNA fragment from pBR322, Proc. Natl. Acad. Sci. USA 86, 1105-1109. link to pdf file

Schreiber, S. L. and Kiessling, L. L. (1989) Further investigations of the type II Diels-Alder route to the bicyclic core of esperamicin/calichemicin reveal a regio-chemical misassignment: Meta vs. para selectivity, Tetrahedron Lett. 30, 433-436. link to pdf file


Schreiber, S. L. and Kiessling, L. L. (1988) Synthesis of the bicyclic core of the esperamicin/calichemicin class of antitumor agents, J. Am. Chem. Soc. 110, 631-633.link to pdf file

Kiessling, L. L. and Schreiber, S L. (1988) Natural product-based leads in cancer chemotherapy, Chemtracts 1, 4-6. link to pdf file


Chen, Y. L., Chang, C. W., Hedberg, K., Guarino, K., Welch, W. M., Kiessling, L., Retsema, J., Haskell, S. L., Anderson, M., Manousos, M., and Barrett, J. F. (1987) Structure activity relationships of 6-(heterocyclyl)-methylene penam sulfones: A new class of b-lactamase inhibitors, J. Antibiotics 40, 803-822. link to pdf file

Book Chapters:

Kiessling, L. L. and Lamanna, A. C. (2003) Multivalency in Biological Systems, Proceedings of the NATO Symposium Chemical Probes in Biology.

Gestwicki, J. E., Cairo, C. W., Borrok, M. J., and Kiessling, L. L. (2003) Visualization and Characterization of Receptor Clusters by Transmission Electron Microscopy, Methods in Enzymol. 362, 301-312.

Kiessling, L. L. and Mann, D. (2001) The Chemistry and Biology of Multivalent Saccharide Displays, Glycochemistry: Principles, Synthesis and Applications, P. G. Wang and C. R. Bertozzi, Eds.

Kiessling, L. L., Young, T., and Mortell, K. H. (2001) Multivalency in Protein Carbohydrate Recognition, Glycoscience I: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, Eds.

Kiessling, L. L. (1998) The Molecular Recognition of Saccharides and Glycoprotein-Inspired Materials, Recent Trends in Molecular Recognition, Proceedings of the Ernst Schering Research Foundation Workshop 26, 183-212.

Kiessling, L. L. and Strong, L. E. (1998) BioActive Polymers, Topics in Organometallic Chemistry 1: Alkene Metathesis in Organic Synthesis, 199-231.

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