Publications

2009

May JF, Kiessling LL (2009) A tethering mechanism for length control in a processive carbohydrate polymerization. Proc Natl Acad Sci USA 106(29):11851-11856

Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. (2009) Ligand binding and substrate discrimination by UDP-Galactopyranose mutase. J Mol Biol. 391(2):327-340 

Kolonko EM, Pontrello JK, Mangold SL, Kiessling LL. (2009) General synthetic route to cell-permeable block copolymers via ROMP. J Am Chem Soc. 131(21):7327-7333

Dykhuizen EC, Kiessling LL. (2009) Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite. Org Lett. 11(1):193-196 

Courtney AH, Puffer EB, Pontrello JK, Yang ZQ Kiessling LL. (2009) Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation. Proc Natl Acad Sci USA 106(8):2500-2505

Borrok MJ, Zhu Y, Forest KT, Kiessling LL. (2009) Structure-based design of a periplasmic binding protein antagonist that prevents domain closure. ACS Chem Biol. 4(6):447-456

Allen MJ, Wangkanont K, Raines RT, Kiessling, LL. (2009) ROMP from ROMP:  A new approach to graft copolymer synthesis. Macromolecules. 42(12):4023-4027

2008

Underbakke ES, Zhu Y, Kiessling LL. (2008) Isotope-coded affinity tags with tunable reactivities for protein footprinting. Angew Chem, Int Ed. 47(50):9677-9680

Mangold SL, Carpenter RT, Kiessling LL. (2008) Synthesis of fluorogenic polymers for visualizing cellular internalization. Org Lett. 10(14):2997-3000. PMID: 18563907

Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008) Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. J Am Chem Soc. 130(21):6706-7. PMID: 18447352

Kolonko EM, Kiessling LL. (2008) A polymeric domain that promotes cellular internalization.
J Am Chem Soc.  130(17):5626-7. PMID: 18393495

Borrok MJ, Kolonko EM, Kiessling LL. (2008) Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array.
ACS Chem Biol. 3(2):101-9. PMID: 18278851

2007

Borrok MJ, Kiessling LL.  (2007) Non-carbohydrate inhibitors of the lectin DC-SIGN.
J Am Chem Soc. 129(42):12780-5. PMID: 17902657

Derda R, Wherritt DJ, Kiessling LL. (2007) Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers. Langmuir. 23(22):11164-7. PMID: 17880250

Chad JM, Sarathy KP, Gruber TD, Addala E, Kiessling LL, Sanders DA.(2007) Site-directed mutagenesis of UDP-galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues. Biochemistry. 46(23):6723-32. PMID: 17511471

Borrok MJ, Kiessling LL, Forest KT. (2007) Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
Protein Sci. 16(6):1032-41. PMID: 17473016

Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol. 2(5):347-55. PMID: 17480050

Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. (2007) A higher degree of difficulty. ACS Chem Biol. 2(4):197-9. No abstract available. PMID: 17455890

Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL. (2007) Activating B cell signaling with defined multivalent ligands. ACS Chem Biol. 2(4):252-62. PMID: 17432821

Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. (2007) Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chem Biol. 2(2):119-27. PMID: 17291050 

Owen, R.M., Carlson, C.B., Xu, J., Mowery, P., Fasella, E., and Kiessling, L.L. (2007) Bifunctional Ligands that Target Cells Displaying the ?v?3 Integrin, ChemBioChem, 8, 68–82.

Carlson, C.B., Mowery, P., Owen, R.M., Dykhuizen, E,C,. and Kiessling, L.L (2007) Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions, ACS Chemical Biology, Vol.2 No. 2, 119.

2006

Kiessling, L.L., Wedde, S.G., and Ronald T. Raines (2006) Symbiosis: Chemical Biology at Wisconsin, ACS Chemical Biology, Vol.1 No. 8, 481.

Kiessling, L.L., Gestwicki, J.E. and Strong, L.E. (2006) Synthetic Multivalent Ligands as Probes of Signal Transduction, Angew. Chem. Int. Ed., 45, 2348 – 2368.

Orner B. P., Liu L., Murphy R.M., and Kiessling L.L. (2006) Phage Display Affords Peptides that Modulate ?-Amyloid Aggregation, J. Am. Chem. Soc., 128, 11882-11889.

Carlson, E. E., May, J. F., and Kiessling, L. L. (2006) Chemical probes of UDP-galactopyranose mutase, Chem Biol. 13, 825-837.

Kiessling, L. L. (2006) Fostering major breakthroughs, ACS Chem. Biol. 1, 1-2.

He, Y., Wilkins, J. P., and Kiessling, L. L. (2006) N-acylsulfonamide linker activation by Pd-catalyzed allylation, Org. Lett. 8, 2483-2485.

Allen, M. J., Raines, R. T., and Kiessling, L. L. (2006) Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization, J. Am. Chem. Soc. 128, 6534-6535.

2005

Pontrello, J.K., Allen, M.J., Underbakke, E,S, and Kiessling, L.L. (2005) Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization, J. Am. Chem. Soc., 127, 14536-14537.

Borrok, D., Borrok, M. J., Fein, J. B., and Kiessling, L. L. (2005) Link between chemotactic response to Ni²⁺ and its adsorption onto the Escherichia coli cell surface, Environ. Sci. Technol. 39, 5227-5233.

Lamanna, A. C., Ordal, G. W., and Kiessling, L. L. (2005) Large increases in attractant concentration disrupt the polar localization of bacterial chemoreceptors, Mol. Microbiol. 57, 774-785.

Soltero-Higgin, M., Carlson, E.E., Phillips, J.H. and Kiessling, L.L. (2005) Identification of Inhibitors for UDP-Galactopyranose Mutase, J. Am. Chem. Soc., 126, 10532-10533.

2004

He, Y., Hinklin, R.J., Chang, J. and Kiessling, L.L. (2004) Stereoselective N-Glycosylation by Staudinger Ligation, Organic Letters, Vol. 6, No. 24, 4479-4482.

Orner, B.P., Derda, R., Lewis, R.L., Thomson, J.A., and Kiessling, L.L. (2004) Arrays for the Combinatorial Exploration of Cell Adhesion, J. Am. Chem. Soc., 126, 10808-10809.

Soltero-Higgin, M. L., Carlson, E. E., Gruber, T. D., and Kiessling, L. L. (2004) A unique catalytic mechanism for UDP-galactopyranose mutase, Nature Mol. Struct. Biol. 11, 539-543.

Mowery, P., Yang,  Z. Q., Gordon, E. J., Dwir, O., Spencer, A. G., Alon, R., and Kiessling, L. L. (2004) Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding, Chem. Biol. 11, 725-732.

Carlson, E. E. and Kiessling, L. L. (2004) Improved chemical synthesis of 1- and 5-Deazariboflavin, J. Org. Chem. 69, 2614-2617.

Griffith, B. R., Allen, B. L., Rapraeger, A. C., and Kiessling, L. L. (2004) A polymer scaffold for protein oligomerization, J. Am. Chem. Soc. 126, 1608-1609.

2003

Smith, E. A., Thomas, W. D., Kiessling, L. L., and Corn, R. M. (2003) Surface plasmon resonance imaging studies of protein–carbohydrate interactions, J. Am. Chem. Soc. 125, 6140-6148.

Schuster, M. C., Mann, D. A., Buchholtz, T. J., Johnson, K. M., and Kiessling, L. L. (2003) Parallel synthesis of glycomimetic libraries that target a C-type lectin, Org. Lett. 5 , 1407-1410.

Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Kiessling, L. L., Yang, Z. Q., Rosen, S. D., and Fisher, S. J. (2003) Trophoblast L-selectin mediates adhesive interactions at the human maternal–fetal interface, Science 299, 405-408.

2002

Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., and Kiessling, L. L. (2002) Influencing receptor–ligand binding mechanisms with multivalent ligand architecture, J. Am. Chem. Soc. 124, 14922-14933.

Yang, Z. Q., Puffer, E. B., Pontrello, J. K., and Kiessling, L. L. (2002) Synthesis of a multivalent display of a CD22-binding trisaccharide, Carbohydrate Res. 337, 1605-1613.

Young, T. and Kiessling, L. L. (2002) A strategy for the synthesis of sulfated peptides, Angew. Chem. Int. Ed. Eng. 41, 3449-3451.

Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., and Kiessling, L. L. (2002) Conserved amplification of chemotactic responses through chemoreceptor interactions, J. Bacteriol. 184, 4981-4987.

Cairo, C. W., Strzelec, A., Murphy, R. M., and Kiessling, L. L. (2002) Affinity-based inhibition of ?-amyloid toxicity, Biochemistry 41, 8620-8629.

Owen, R. W., Gestwicki, J. E., Young, T., and Kiessling, L. L. (2002) Synthesis and applications of end-labeled neoglycopolymers, Org. Lett. 4, 2293-2296.

Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., and Kiessling, L. L. (2002) Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy, Anal. Biochem. 305, 149-155.

Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., and Kiessling, L. L. (2002) Cell aggregation by scaffolded receptor clusters, Chem. Biol. 9, 163-169.

Cairo, C. W., Gestwicki, J. E., Kanai, M., and Kiessling, L. L. (2002) Control of multivalent interactions by binding epitope density, J. Am. Chem. Soc. 124, 1615-1619.

Kiessling, L. L. and Cairo, C. W. (2002) Hitting the sweet spot, Nature Biotech. 20, 234-235.

Gestwicki, J. E. and Kiessling, L. L. (2002) Inter-receptor communication through arrays of bacterial chemoreceptors, Nature 415, 81-84.

Hinklin, R. J. and Kiessling, L. L. (2002) Para-methoxybenzyl ether cleavage by polymer-supported sulfonamides, Org. Lett. 4, 1131-1133.

2001

Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., and Kiessling, L. L. (2001) Designed potent multivalent chemoattractants for Escherichia coli, Bioorg. Med. Chem. 9, 2387-2393.

Marlow, A. L. and Kiessling, L. L. (2001) Improved chemical synthesis of UDP-galactofuranose, Org. Lett. 3, 2517-2519.

Lowe, T. L., Strzelec, A., Kiessling, L. L., and Murphy, R. M. (2001) Structure-function relationships for Inhibitors of b-amyloid toxicity containing the recognition sequence KLFVV, Biochemistry 40, 7882-7889.

Hinklin, R. J. and Kiessling, L. L. (2001) Glycosyl sulfonylcarbamates: New glycosyl donors with tunable reactivity, J. Am. Chem. Soc. 123, 3379-80.

Nilsson, B. L., Kiessling, L. L., and Raines, R. T. (2001) High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide, Org. Lett. 3, 9-12.

Bertozzi, C. R. and Kiessling, L. L. (2001) Chemical glyobiology, Science 291, 2357-2364.

Kiessling, L. L. (2001) The Periodic Table, Chem. Eng. News 79, 246.

Steinmann, J. G., Phillips, J. H., Sanders, W. J., and Kiessling, L. L. (2001) Synthesis of cyclic sulfates by halocyclization, Org. Lett. 3, 3557-3559.

2000

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Visualization of single multivalent receptor-liggand complexes by transmission electron microscopy, Angew. Chem. Int. Ed. Eng. 39, 4567-4570.

Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., and Adler, J. (2000) Evolutionary conservation of methyl-accepting chemotaxis protein location in bacteria and archea, J. Bacteriol. 182, 6499-6502.

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Tuning chemotactic responses with synthetic multivalent ligands, Chem. Biol. 7, 583-591.

Nilsson, B. L., Kiessling, L. L, and Raines, R. T. (2000). Staudinger ligation: A peptide from a thioester and azide, Org. Lett. 2, 1939-1941.

Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L. and Adler, J. (2000) Motility and chemotaxis of filamentous cells of Escherichia coli, J. Bacteriol. 182, 4337-4342.

Burke, S. D., Zhao, Q., Schuster, M. C., and Kiessling, L. L. (2000) Synergistic formation of soluble lectin clusters by a templated multivalent saccharide ligand, J. Am. Chem. Soc. 122, 4518-4519.

Gordon, E. J., Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Synthesis of end-labeled multivalent ligands for exploring cell surface receptor–ligand interactions, Chem. Biol. 7, 9-16.

Kiessling, L. L., Gestwicki, J. E., and Strong, L. E. (2000) Synthetic multivalent ligands in the exploration of cell surface interactions, Curr. Opin. Chem. Biol. 4, 696-703.

Kiessling, L. L, Strong, L. E., and Gestwicki, J. E. (2000) Principles for multivalent ligand design. Annu. Reports Med. Chem 35, 321-330.

1999

Pohl, N. L. and Kiessling, L. L. (1999) Scope of multivalent ligand function: Lactose-bearing neoglycopolymers by ring-opening metathesis polymerization, Synthesis SI, 1515-1519.

Strong, L. E. and Kiessling, L. L. (1999) A general synthetic route to defined, biologically active multivalent arrays, J. Am. Chem. Soc. 121, 6193-6196.

Pallitto, M. M., Ghanta, J., Heinzelman, P., Kiessling, L. L., and Murphy, R. M. (1999) Recognition sequence design for peptidyl modulators of b-amyloid aggregation and toxicity, Biochemistry 38, 3570-3578.

Sanders, W. J., Gordon, E. J., Dwir, O., Beck, P. J., Alon, R. T., and Kiessling, L. L. (1999) Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics, J. Biol. Chem. 274, 5271-5278.

Kiessling, L. L., DeGrado, W. F., and Ecstein, F. (1999) Modulation of nucleic acids, carbohydrates and proteins to different task, Curr. Opin. Chem. Biol. 3(6), 641-642.

1998

Mann, D. A., Kanai, M., Maly, D. J., and Kiessling, L. L. (1998) Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for Concanavalin A, J. Am. Chem. Soc. 120, 10375-10383.

Gordon, E. J., Strong, L. E., and Kiessling, L. L. (1998) Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin, Bioorg. Med. Chem. 6, 1293-1299.

Gordon, E. J., Sanders, W. J., and Kiessling, L. L. (1998) Synthetic ligands point to cell surface strategies, Nature 392, 30-31.

Kiessling, L. L. and Gordon, E. J. (1998) Transforming the extracellular environment through proteolysis, Chemistry & Biology 5, R49-62.

1997

Sanders, W. J., Manning, D. D., Koeller, K., and Kiessling, L. L. (1997) Synthesis of sulfated trisaccharide ligands for the selectins, Tetrahedron Symposium in Print: Synthetic Methods 53, 16391-16422.

Kanai, M., Mortell, K. H., and Kiessling, L. L. (1997) Varying the size of multivalent ligands: The dependence of Concanavalin A inhibition on neoglycopolymer length, J. Am. Chem. Soc. 119, 9931-9932.

Pohl, N. L. and Kiessling, L. L. (1997) Para-chloro benzyl groups as stabilizers of the glycosidic linkage, Tetrahedron Lett. 38, 6985-6988.

Manning, D. D., Strong, L. E., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Neoglycopolymer inhibitors of the selectins, Tetrahedron Symposium in Print: Bioorg. Chem. 53, 11937-11952.

Manning, D. D., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Synthesis of sulfated neogly-copolymers: Selective P-selectin inhibitors, J. Am. Chem. Soc. 119, 3161-3162.

Kurutz, J. K. and Kiessling, L. L. (1997) Solution conformation of Lewis a-derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions, Glycobiol. 7, 337-347.

Hegg, E., Deal, K., Kiessling, L. L, and Burstyn, J. N. (1997) Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper (II) macrocycle Cu([9]aneN3)Cl2, Inorg. Chem. 36, 1715-1718.

Schuster, M. C., Mortell, K. H., Hegeman, A. D., and Kiessling, L. L. (1997) Neoglycopolymers produced by ring-opening metathesis polymerization: Decreasing saccharide density increases activity, J. Mol. Cat. A: Chemical 116, 209-216.

1996

Schueller, C. M., Manning, D. D., and Kiessling, L. L. (1996) Preparation of R-(+)-7-oxabicyclo[2.2.1]hept-5-ene-exo-2-carboxylic acid, a precursor to substrates for the ring opening metathesis polymerization, Tetrahedron Lett. 37, 8853-8856.

Dantzman, C. L. and Kiessling, L. L. (1996) Reactivity of a 2' thio nucleotide analog, J. Am. Chem. Soc. 118, 11715-11719.

Ghanta, J., Shen, C.-L., Kiessling, L. L., and Murphy, R.M. (1996) A strategy for designing inhibitors of ?-amyloid toxicity, J. Biol. Chem. 271, 29525-29528.

Sanders, W. J., Katsumoto, T. R., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) L-selectin–carbohydrate onteractions: Relevant modifications of the Lewis x trisaccharide, Biochemistry 35, 14862-14867.

Brüning, J. and Kiessling, L. L. (1996) Convergent synthesis of sulfated bivalent glycopeptides as selectin ligands, Tetrahedron Lett. 37, 2907-2910.

Manning, D. D., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) Tin-mediated phosphorylation: Synthesis and selectin binding of a phospho Lewis a analog, Tetrahedron Lett. 37, 1953-1956.

Mortell, K. H., Weatherman, R. V., and Kiessling, L. L. (1996) Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization, J. Am. Chem. Soc. 118, 2297-2298.

Weatherman, R. V., Mortell, K. H., Chervenak, M., Kiessling, L. L., and Toone, E. J. (1996) Specificity of C-Glycoside complexation by mannose/glucose specific lectins, Biochemistry 35, 3619-3624.

Weatherman, R. V. and Kiessling, L. L. (1996) Fluorescence anisotropy assays reveal affinities of C- and O-Glycosides for Concanavalin A, J. Org. Chem. 61, 534-538.

Kiessling, L. L. and Pohl, N. L. (1996) Strength in numbers: Non-natural polyvalent carbohydrate derivatives, Chemistry & Biology 3, 71-77.

1995

Kiessling, L. L. (1995) Creating molecules: Evolution of randomness. Graven Images 2, 222-228.

Manning, D. D., Bertozzi, C. R., Pohl, N. L., Rosen, S. D., and Kiessling, L. L. (1995) Selectin–saccharide interactions: Revealing structure–function relationships with chemical synthesis, J. Org. Chem. 60, 6254-6255.

1994

Mortell, K. H., Gingras, M., and Kiessling, L. L. (1994) Synthesis of cell agglutination inhibitors by aqueous ring-opening metathesis polymerization, J. Am. Chem. Soc. 116, 12053-12054.

Sanders, W. and Kiessling, L. L. (1994) Stereoselective Lewis acid-catalyzed glycosylation of cyclic sulfites, Tetrahedron Lett. 35, 7335-7338.

1993

Griffin, L. C., Kiessling, L. L, Beal, P. A., Gillespie, P., and Dervan, P. B. (1992) Recognition of all four base pairs of double helical DNA by triple helix formation: Design of non-natural deoxyribonucleosides for pyrimidine-purine base pair binding, J. Am. Chem. Soc. 114, 7976-7982.

Kiessling, L. L., Griffin, L. C., and Dervan, P. B. (1992) Flanking sequence effects within the pyrimidine triple helix motif characterized by affinity cleaving, Biochemistry 31, 2829-2834.

1989

Hawley, R. C., Kiessling, L. L., Schreiber, S. L. (1989) Model of the interactions of calichemicin g1 with a DNA fragment from pBR322, Proc. Natl. Acad. Sci. USA 86, 1105-1109.

Schreiber, S. L. and Kiessling, L. L. (1989) Further investigations of the type II Diels-Alder route to the bicyclic core of esperamicin/calichemicin reveal a regio-chemical misassignment: Meta vs. para selectivity, Tetrahedron Lett. 30, 433-436.

1988

Schreiber, S. L. and Kiessling, L. L. (1988) Synthesis of the bicyclic core of the esperamicin/calichemicin class of antitumor agents, J. Am. Chem. Soc. 110, 631-633.

Kiessling, L. L. and Schreiber, S L. (1988) Natural product-based leads in cancer chemotherapy, Chemtracts 1, 4-6.

1987

Chen, Y. L., Chang, C. W., Hedberg, K., Guarino, K., Welch, W. M., Kiessling, L., Retsema, J., Haskell, S. L., Anderson, M., Manousos, M., and Barrett, J. F. (1987) Structure–activity relationships of 6-(heterocyclyl)-methylene penam sulfones: A new class of b-lactamase inhibitors, J. Antibiotics 40, 803-822.

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