Publications
131. Sampath, H., Flowers, M.T., Liu, X., Paton, C.M., Sullivan, R., Chu, K., Zhao, M., Ntambi, J.M.
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. JBC 284(30):19961-73. (2009)
130. Miyazaki, M., Sampath, H., Liu, X., Flowers, M.T., Chu, K., Dobrzyn, A., Ntambi, J.M. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun. 380(4):818-22 (2009)
129. Flowers, M.T. and Ntambi, J.M. Stearoyl-CoA Desaturase and its Relation to High-Carbohydrate Diets and Obesity. BBA 1791 (2):85-91 (2009)
128. Paton, C.M., Ntambi, J.M. Biochemical and Physiological Function of Stearoyl-CoA Desaturase. Am J Physiol Endocrinol Metab. 297:28-37 (2009)
127. Flowers, M.T. and Ntambi, J.M. Gene Inactivation and Tissue-specific Metabolism. In: Encyclopedia of life sciences. John Wiley & Sons,Ltd: Chichester http://www.els.net/
126. Miyazaki, M.,and Ntambi, J.M. Fatty acid desaturation and elongation in mammals. In: Biochemistry of Lipids, Lipoproteins and Membranes, 5th edition. D.E. Vance and J.E. Vance ed. 191-211 (2008)
125. Zarnowski, R., Dobrzyn, A., Ntambi, J.M., and Woods, J.P. Ferrous, but not Ferric, Iron Maintains Homeostasis in Histoplasma capsulatum Triacylglycerides. 57(2):153-7 (2008)
124. Zarnowski, R., Dobrzyn, A., Ntambi, J.M., and Woods, J.P. Neutral Storage Lipids of Histoplasma capsulatum : Effect of Culture Age. 56(2):110-4 (2008)
123. Dobrzyn, P., Sampath, H., Dobrzyn, A., Miyazaki, M., Ntambi, J.M. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am J Physiol Endocrinol Metab. 294(2):E357-64 (2008)
122. MacDonald, M.J., Dobrzyn, A., Ntambi, J.M., Stoker, S.W. The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Archives of Biochemistry and Biophysics, Volume 470, Issue 2, 153-162 (2008)
121. Flowers, M.T., Keller, M.P., Choi, Y., Lan, H., Kendziorski, C., Ntambi, J.M., Attie, A.D. Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics. 33:361-72 (2008)
120. Mar-Heyming, R., Miyazaki, M., Weissglas-Volkov, D., Kolaitis, N.A., Sadaat, N., Plaisier, C., Pajukanta, P., Cantor, R.M., de Bruin, T.W., Ntambi, J.M., Lusis, A.J.. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 28:1193-9 (2008)
119. Flowers, M.T., and Ntambi, J.M. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol. 19:248-56. Review (2008)
118. Sampath, H., and Ntambi, J.M. Role of stearoyl-CoA desaturase in human metabolic disease. Future Lipidology, Vol. 3, No. 2, 163-173 (2008)
117. Dobrzyn, P., Ntambi, J.M., Dobrzyn, A. Stearoyl-CoA desaturase: A novel control point of lipid metabolism and insulin sensitivity. Eur. J. Lipid Sci. Technol, 110, 93-100 (2008)
116. Chen, C., Shah, Y.M., Morimura, K., Krausz, K.W., Miyazaki, M., Richardson, T.A., Morgan, E.T., Ntambi, J.M., Idle, J.R., Gonzalez, F.J. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab. 7:135-47 (2008)
115. Zarnowski, R., Dobrzyn, A., Ntambi, J.M., Woods, J.P. Neutral storage lipids of Histoplasma capsulatum: effect of culture age. Curr Microbiol. Feb;56(2):110-4 (2008)
114. Miyazaki, M., Flowers, M.T., Sampath, H., Chu, K., Otzelberger, C., Liu, X., Ntambi, J.M.. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 6:484-96 (2007)
113. McGinnis, J.M., Birt, D.F., Brannon, P.M., Carroll, R.J., Gibbons, R.D., Hazzard, W.R., Kamerow, D.B., Levin, B., Ntambi, J.M., Paneth, N., Rogers, D., Saftlas, A.F., Vaughan, W. Letters to the Editor: Reply to BN Ames et al. Am. J. Clinical Nutrition, 86:522-524 (2007)
112. Mulanga, F.I., Sampath, H., Marlett, J.A., Ntambi, J.M. Impact of processing technique on apparent bioavaibility of cooking banana (matooke) starch. African Journal of Biochemistry Research. 1(5), 72-77 (2007)
111. Zarnowski, R., Miyazaki, M., Dobrzyn, A., Ntambi, J.M., Woods, J.P. Typing of Histoplasma capsulatum strains by fatty acid profile analysis. J Med Microbiol. 56:788-97 (2007)
110. Attie, A.D., Flowers, M.T., Flowers, J.B., Groen, A.K., Kuipers, F., Ntambi, J.M. Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes. Nutr Rev. 65:S35-8. Review (2007)
109. Flowers, J.B., Rabaglia, M.E., Schueler, K.L., Flowers, M.T., Lan, H., Keller, M.P., Ntambi J.M., Attie, A.D. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes. 56(5):1228-39 (2007)
108. Thomson, B., Ahrens, J.M., Ntambi, J.M., DeLuca, H.F., Clagett-Dame, M. 2-Methylene-19-nor-1alpha-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPARgamma2 gene transcription.
Arch Biochem Biophys. 460(2):192-201 (2007)
107. Sampath, H. and Ntambi, J. M. Polyunsaturated fatty acids and regulation of gene expression. In: Fatty Acids in Foods and Their Health Implications, Third Edition C. K. Chow, ed., CRC Press. 727-739 (2007)
106. Sampath, H., Miyazaki, M., Dobrzyn, A., Ntambi, J.M. Stearoyl CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 282: 2483-93 (2007).
105. Marwah, A., Gomez, F. E., Marwah, P, Ntambi, J. M., Fox, B. G. and Lardy, H. Redox reactions of dehydroepiandrosterone and its metabolites in differentiating 3T3-L1 adipocytes. A liquid chromatographic-mass spectrometric study. Arch. Biochem. Biophys 456, 1-7 (2006).
104. Flowers, M. T., Groen, A. K., Oler, A., Gray-Keller, M. P., Choi, Y., Schueler, K. L., Richards, O. C., Lan, H., Miyazaki, M., Kuipers, F., Kendziorski, C., Ntambi, J. M. and Attie, A. D. Cholesterol and hypercholesterolemia in SCD1-deficient mice fed a low-far, high-carbohydrate diet. J Lipid Res. 2006 Dec;47(12):2668-80.
103. Chu, K., Miyazaki, M., Man, W. C. and Ntambi, J. M. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26, 6786-6798 (2006).
102. McGinnis, J. M., Birt, D. F., Brannon, P. M., Carroll, R. J., Gibbons, R. D., Hazzard, W. R., Kamerow, D. B., Levin, B., Ntambi, J. M., Paneth, N., Rogers, D., Saftlas, A. F. and Vaughan, W. National Institutes of Health State-of-the-Science Conference Statement: Multivitamin/Mineral Supplements and Chronic Disease Prevention. Annals of Internal Medicine, Vol. 145, Issue No. 5, pp. 364-371 (2006).
101. Man, W. C., Miyazaki, M., Chu, K. and Ntambi, J. M. Co-localization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J. Lipid Res. 47, 1928-1939 (2006).
100. Sampath, H. and Ntambi, J. M. Regulation of gene expression by polyunsaturated fatty acids. Heart and Metabolism, 2006: 32:32-35
99. Biddinger, S. B., Miyazaki, M., Boucher, J., Ntambi, J. M. and Kahn, C. R. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55, 2032-2041 (2006).
98. Flowers, M. T., Miyazaki, M., Liu, X. and Ntambi, J. M. Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance. J. Clin. Invest. 116, 1478-1481 (2006).
97. Ntambi, J. M. Lipids, genes, and health. Science 312, 698 (2006).
96. Miyazaki, M., Bruggink, S. M. and Ntambi, J. M. Identification of mouse palmitoyl-coenzyme A D9-desaturase. J. Lipid Res. 47, 700-704 (2006).
95. Sampath, H. and Ntambi, J. M. Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferators-activated receptor-a: Independent and interactive roles in the regulation of lipid metabolism. Curr. Opin. Clin. Nutr. Metab. Care 9, 84-88 (2006).
94. Harini Sampth and James M. Ntambi (2006) Fate and Intermediary metabolism of Stearic Lipids In Press
93. Ntambi JM, Sampth H. (2005) Dietary Regulation of Stearoyl-CoA Desaturase-1 expression (2005). Proceedings of the 18th International Congress of Nutrition 19-23 September, 2005 Durban South Africa.
92. Weng Chi Man, Makoto Miyazaki, Kiki Chu and James M. Ntambi (2006). Membrane Topology of Stearoyl-CoA Desaturase-1. J. Biol. Chem. Jan 13; 281(2): 1251-1260.
91. Matthew Hulver, Jason R. Berggren, Michael J. Carper, Makoto Miyazaki, James M. Ntambi, Eric P. Hoffman, G. Lynis Dohm, Joseph A. Houmard and Deborah M. Muoio (2005) Elevated Stearoyl-CoA Desaturase-1 Expression in Skeletal Muscle Contributes to Abnormal Fatty Acid Partitioning in Obese Humans. Cell Metab. Oct; 2(4): 251-261.
90. Makoto Miyazaki, Agnieszka Dobrzyn, Peter M. Elias and James M. Ntambi (2005) Stearoyl-CoA desaturse-2 gene expression is required for lipid synthesis during early skin and liver development. Proc. Natl. Acad. Sci. USA. Aug 30; 102(35): 12501-12506.
89. Agnieszka Dobrzyn, Pawel Dobrzyn, Makoto Miyazaki, James M. Ntambi (2005) Dietary Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues. Biochem. Biophys. Res. Commun. Jul 8; 332(3): 892-6.
88. Agnieszka Dobrzyn and James M. Ntambi (2005) Stearoyl-CoA desaturase as a new drug target for obesity treatment Prostaglandins Leukot Essent Fatty Acids. Jul; 73(1): 35-41.
87. Agnieszka Dobrzyn, Pawel Dobrzyn, Makoto Miyazaki, Harini Sampath, Kiki Chu, and James M. Ntambi (2005) Stearoyl-CoA desaturase 1 deficiency increases CTP: choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J. Biol. Chem. Jun 17; 280(24): 23356-23362.
86. Agnieszka Dobrzyn and James Ntambi (2005) Stearoyl-CoA desaturase: a therapeutic target of insulin resistance and diabetes. Drug Discovery Today: Therapeutic Strategies. 2(2): 125-128.
85. Sudha B. Biddinger, Katrine Almind, Makoto Miyazaki, Efi Kokkotou, James M. Ntambi, and C. Ronald Kahn (2005) Sterol Regulatory Element-Binding Protein-1c and Stearoyl-CoA Desaturase 1 Mediate the Effects of Diet and Genetic Background on the Development of the Metabolic Syndrome. Diabetes May; 54(5): 1314-1323.
84. Harini Sampath and James M. Ntambi (2005) Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr. 25: 317-40.
83. Agnieszka Dobrzyn and James M. Ntambi (2005) Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obesity Reviews. May; 6(2): 169-174.
82. Agnieszka Dobrzyn, Pawel Dobrzyn, Seong-Ho Lee, Makoto Miyazaki, Paul Cohen, Esra Asilmaz, D. Grahame Hardie, Jeffrey M. Friedman and James M. Ntambi (2004) Stearoyl-CoA desaturase 1 deficiency reduces ceramide synthesis by down-regulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J. Physiol. Endocrinol. Metab. Mar; 288(3): 599-607.
81. Shaikh Mizanoor Rahman, Agnieszka Dobrzyn, Seong-Ho Lee, Pawel Dobrzyn Makoto Miyazaki and James M. Ntambi (2005) Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am J. Physiol. Endocrinol. Metab. Feb; 288(2): 381-7.
80. James M. Ntambi, Makoto Miyazaki and Agnieszka Dobrzyn (2004). Regulation of Stearoyl-CoA Desaturase Expression. Lipids. Nov; 39(11): 1061-1065.
79. Harini Sampath and James M. Ntambi (2004) Polyunsaturated Fatty Acid Regulation of Gene expression (2004). Nutrition Reviews. Sep; 62(9): 333-339.
78. Seong-Ho Lee, Agnieszka Dobrzyn, Shaikh Mizanoor Rahman, Pawel Dobrzyn, Makoto Miyazaki and James M. Ntambi (2004) Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis, but causes hypothermia in cold environment J. Lipid. Res. Sep 45(9): 1674-1682.
77. Makoto Miyazaki, Agnieszka Dobrzyn, Harini Sampath, Seong-Ho Lee, Weng Chi Man, Kiki Chu, Jeffrey M. Peters, Frank J. Gonzalez and James M. Ntambi (2004) Reduced adiposity and liver steatosis induced by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J. Biol. Chem. Aug 13; 279(33): 35017-35024.
76. Makoto Miyazaki, Agnieszka Dobrzyn, Weng Chi Man, Kiki Chu, Harini Sampath, Hyoun-Ju Kim and James M. Ntambi (2004) Stearoyl-CoA desaturase gene 1 expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element binding protein-1c-dependent and independent mechanisms J. Biol. Chem. June 11; 279(24): 25164-25171.
75. Dobrzyn, P., Dobrzyn, A., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, G. D., Friedman, J. M. and Ntambi, J. M. (2004) Stearoyl-CoA desaturase-1 (SCD1) deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. USA. April; 101(17): 6409-6414.
74. Richard A. Wilson, Perng-Kuang Chang, Agnieszka Dobrzyn, James M. Ntambi, Robert Zarnowski and Nancy P. Keller (2004). Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development. Fungal Genetics and Biology May; 41(5): 501-50.
73. Ntambi, J. M. and Georgieff, M. (2004) Testing Ingredients with Preclinical Studies Infant formula: Evaluating the Safety of New Ingredients, Institute of Medicine, National Research Council of the National Academies.
72. Esra Aszlmaz, Paul Cohen, Makoto Miyazaki, Pawel Dobrzyn, Kohjiro Ueki, G. Fayzikhodjaeva, Alexander A. Soukas, C. Ronald Kahn, James M. Ntambi, Nicholas D. Socci and Jeffrey M. Friedman (2004) Site and mechanism of leptin action in a mouse model of congenital lipodystrophy. Journal of CIinical Investigation. Feb; 113(3): 414-24.
71. Dobrzyn, A. and Ntambi, J. M. (2004) The role of stearoyl-CoA desaturase in body weight regulation. Trends in Cardiovascular Medicine, 14, 77-81.
70. James M. Ntambi and Makoto Miyazaki (2004) Regulation of Stearoyl-CoA Desaturases and Role in Metabolism. Prog Lipid Res. 2004 Mar; 43(2): 91-104.
69. Cohen P., Ntambi J.M., and Friedman J.M. (2003) Stearoyl-CoA Desaturase-1 and the Metabolic Syndrome. Current Drug Targets - Immune, Endocrine & Metabolic Disorders, vol. 3, no. 4, pp. 271-280(10) Bentham Science Publishers.
68. Shaikh Mizanoor Rahman, Agnieszka Dobrzyn, Seong-Ho Lee, Makoto Miyazaki, and James M. Ntambi (2003) Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A. Sep 16; 100(19): 11110-5.
67. Makoto Miyazaki, Mark J. Jacobson, Weng Chi Man, Paul Cohen, Esra Asilmaz, Jeffrey M. Friedman and James M. Ntambi (2003) Identification and characterization of murine SCD4: a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem. Sep 5; 278(36): 33904-11.
66. James M. Ntambi and Makoto Miyazaki (2003) Recent insights into Stearoyl-CoA Desaturase-1. Curr Opin. Lipidol 14.
65. Michael W. Pariza, Yeonhwa Park, Xiaofang Xu, James Ntambi, Kihwa Kang (2003) Speculation on the mechanisms of action of conjugated linoleic acid. Chapter in: Advences in Conjugated linoleic acid research, Volume 2, J.L. Sebedio, AOCS Press, Champaign, IL.
64. Miyazaki, M., Gomez, F. E. and Ntambi, J. M. (2003). Presence of a palmitoyl-CoA desaturase in the preputial gland of the mouse. Advance Research on Plant Lipids: Proceedings of the 15th International Symposium on Plant Lipids, Okazaki, Japan. 95-99.
63. Miyazaki, M and Ntambi, J. M. (2003). Physiological role of stearoyl-CoA desaturase. Prostaglandins Leukot. Essent. Fatty Acids 68, 113-121.
62. F, Enrique Gomez, Dale E. Bauman, James M. Ntambi and Brian G. Fox (2003) Effects of Sterculic Acid on Stearoyl-CoA Desaturase (SCD) in Differentiating 3T3-L1 Adipocytes BBRC 300, 316-326.
61. Makoto Miyazaki and James M. Ntambi (2003) Physiological role of stearoyl-CoA desaturase. Prostaglandins Leukot. Essent. Fatty Acids 68, 113-121
60. Makoto Miyazaki, F. E. Gormez and James M. Ntambi (2002) Lack of Stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA D6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial gland of the mouse J. Lipid Res. 43, 2146-2154.
59. Alan D. Attie, Ronald M. Krauss, Mark P. Gray-Keller, Alison Brownlie, Makoto Miyazaki, John J. Kastelein, A.Jake Lusis, Anton F.H. Stalenhoef, Jonathan P. Stoehr, Michael R. Hayden, and James M. Ntambi (2002) Plasma Triglycerides in Human and Mouse Hypertriglyceridemia J. Lipid Res 43, 1899-1907.
58. Hyoun-Ju Kim, Makoto Miyazaki, and James M. Ntambi (2002) Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase 1 gene by Sterol Regulatory Element-binding Protein-1 independent mechanism J. Lipid Res. 43, 1750-1757
57. Ntambi, J. M., Park, Y., Peters, J. M. and Pariza, M. W. (2002). Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase. CJAP, 27, 617-627.
56. Cohen, P., Miyazaki, M., Hudgins, L. C., Socci, N D, Ntambi, J. M., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., Sharma, R. and Friedman, J. M. (2002). Energy expenditure and treating obesity. Science 298, 539-541.
55. James M. Ntambi Makoto Miyazaki, Jonathan P. Stoehr, Hong Lan, Christina M. Kendziorski, Brian S. Yandell, Paul Cohen, Jeffrey Friedman and Alan D. Attie (2002) Loss of Stearoyl CoA Desaturase-1 Function Protects Mice Against Adiposity Pro. Nat. Acad. Sci 99, 11482-11486
54. Paul Cohen1, Makoto Miyazaki, Nicholas D. Socci, Aaron Hagge-Greenberg Wolfgang Liedtke Alexander A. Soukas, Ratnendra Sharma, Lisa C. Hudgins4, James M. Ntambi and Jeffrey M. Friedman (2002) Role for stearoyl-CoA desaturase-1 in leptin mediated weight loss Science 297, 240-243.
53. Youngjin Choi, Yeonhwa Parka, Jayne M. Storkson, Michael Pariza and James M. Ntambi (2002) Inhibition of stearoyl-CoA Desaturase activity by the cis-9, trans-11 isomer and the trans ?10, cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells BBRC 294, 785-790.
52. Hyoun-Ju Kim Makoto Miyazaki, Weng Chi Man and Ntambi, J. M. (2002). Sterol Regulatory Element Binding proteins (SREBPs) as Regulators of Lipid Metabolism: Polyunsaturate Fatty Acids Oppose Cholesterol-Mediated Induction of SREBP-1c Maturation. Annals of the New York Academy of Sciences 967, 34-42
51. Enrique F. Gomez, Makoto Miyazaki, Padma Marwah, Henry A. Lardy, James M. Ntambi, and Brian G. Fox, (2002). Molecular Differences Caused by Differentiation of 3T3-L1 Preadipocytes in the Presence of either Dehydroepiandosterone (DHEA) or 7-Oxo-DHEA. Biochemistry, 41, 5473-5482.
50. Lasky, D. and Ntambi, J. M. (2002). Obesity and gender differences in the risk of type 2 diabetes mellitus in Uganda. Nutrition 18 (5) 417-421
49. Makoto Miyazaki Hyoun-Ju Kim, Weng Chi Man and Ntambi, J. M (2001) Oleoyl-CoA is the Major De novo Product of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2,3-Diacylglycerol. J. Biol. Chem. 276, 39455-39461
48. Miyazaki, M. and Ntambi, J. M. (2001) Targeted Disruption of Stearoyl-CoA Desaturase1 Gene in Mice Causes Atrophy of Sebaceous and Meibomian Glands and Depletion of Wax Esters in the Eyelid. J. Nutr. 131, 2260-2268.
47. Bene, H., Lasky, D. and Ntambi, J. M. (2001). The cloning and characterization of the human stearoyl-CoA desaturase gene promoter: Transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem. Biophys. Res. Commun. 284, 1194-1198.
46. Choi, Y., Park, Y., Pariza, M. W. and Ntambi, J. M. (2001). Regulation of stearoyl-CoA desaturase activity by the trans-10, cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem. Biophys. Res. Commun. 284, 689-693.
45. Ntambi, J. M. and Kim, Y.-C. (2001). Regulation of stearoyl-CoA desaturase gene expression: Role of polyunsaturated fatty acids. In: Nutrition and Gene Expression, CRS Press, pp. 49-61.
44. Miyazaki, M., Kim, Y.-C. and Ntambi, J. M. (2001). A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 42, 1018-1024.
43. Ntambi, J. M. and Bene, H. (2001). Polyunsaturated fatty acid regulation of gene expression. J. Mol. Neurosci. 16, 189-194
42. Ntambi, J. M. and Kim, Y.-C. (2000). Adipocyte differentiation and gene expression. J. Nutr. 130, 3122S-3125S.
41. Miyazaki, M., Kim, Y.-C., Gary-Keller, M. P., Attie, A. D. and Ntambi, J. M. (2000). The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption in the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 275, 30132-30138.
40. Park, Y., Storkson, J. M., Ntambi, J. M., Cook, M. E., Sih, C. J. and Pariza, M. (2000). Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486, 285-292.
39. Kim, Y.-C., Gomez, E., Fox, B. G. and Ntambi, J. M. (2000). Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. J. Lipid Res. 41, 1310-1316.
38. Choi, Y., Kim, Y.-C., Han, Y.-B., Park, Y., Pariza, M. W. and Ntambi, J. M. (2000). The trans-10, cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase gene expression in 3T3-L1 adipocytes. J. Nutr. 130, 1920-1924.
37. Kim, Y.-C., Gomez, E., Fox, B. G. and Ntambi, J. M. (2000). Regulation of stearoyl-CoA desaturase 1 gene expression in preadipocyte differentiation, diabetes and obesity. In: Adipocyte Biology and Hormone Signaling, 27th Steenbock Symposium, Madison, WI, June, 1999 (J. M. Ntambi, ed.), IOS Press, The Netherlands, pp. 69-78.
36. Ntambi, J. M. and Sessler, A. M. (1999). Fatty acid regulation of gene expressions and fat cell differentiation. In: Fatty Acids in Foods and Their Health Implications, Chapter 28 (C. K. Chow, ed.), Marcel Dekker Inc., New York, pp. 597-606.
35. Kim, Y.-C. and Ntambi, J. M. (1999). Regulation of stearoyl-CoA desaturase genes: Role in cellular metabolism and preadipocyte differentiation. Biochem. Biophys. Res. Commun. 266, 1-4.
34. Ntambi, J. M. (1999). Regulation of stearoyl-CoA desaturase in preadipocyte differentiation and metabolism. Chem. Phys. Lipids 101, 142.
33. Ntambi, J. M. (1999). Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40, 1549-1558.
32. Ntambi, J. M., Choi, Y. and Kim, Y.-C. (1999). Regulation of stearoyl-CoA desaturase by conjugated linoleic acid AOCS. In: Conjugated Linoleic Acid: Biochemical, Nutritional, Clinical, Cancer and Methodological Aspects, Vol. 26, pp. 340-347.
31. Miller, C. C. and Ntambi, J. M. (1998). The role of prostaglandin F2a in the inhibition of fat cell differentiation. Recent Res. Develop. in Lipids Res. 2, 11-19.
30. Lee, K. N., Pariza M. W. and Ntambi, J. M. (1998). Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Commun. 248, 817-821
29. Singh, M. and Ntambi, J. M. (1998). Nuclear Factor 1 is essential for expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation. Biochim. Biophys. Acta 1398, 148-156.
28. Sessler, N. and Ntambi, J. M. (1998). Polyunsaturated fatty acid regulation of gene expression. J. Nutr. 128, 923-926.
27. Waters, K. M., Miller, C. W. and Ntambi, J. M. (1997). Localization of a polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene 1. Biochim. Biophys. Acta 1349, 33-42.
26. Ntambi, J. M. (1997). Fat cell differentiation blocked by prostaglandin F2a stimulation of the prostanoid FP2 receptor. Emerging Therapeutic Targets 1, 237-240.
25. Waters, K. M., Miller, C.W. and Ntambi, J. M. (1997). Localization of a negative thyroid hormone-response element in hepatic stearoyl-CoA desaturase gene 1. Biochem. Biophys. Res. Commun. 233, 838-843.
24. Miller, C. W., Waters, K. M. and Ntambi, J. M. (1997). Regulation of hepatic stearoyl-CoA desaturase gene 1 by vitamin A. Biochem. Biophys. Res. Comm. 231, 206-210.
23. Lee, K. N., Pariza, M. and Ntambi, J. M. (1996). Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice. Biochim. Biophys. Acta 1304, 85-88.
22. Miller, C. W., Casimir, D. A. and Ntambi, J. M. (1996). The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglindin F2a. Endocrinology 137, 5641-5650.
21. Sessler, A., Kaur, N., Palta, J.P. and Ntambi, J. M. (1996). Regulation of stearoyl-CoA desaturase1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocyes. J. Biol. Chem. 271, 29854-29858.
20. Casimir, D. A. and Ntambi, J. M. (1996). cAMP activates the expression of stearoyl-CoA desaturase gene 1 during early preadipocyte differentiation. J. Biol. Chem. 271, 29847-29853.
19. Casimir, D. A., Miller, C. W. and Ntambi, J. M. (1996). Preadipocyte differentiation blocked by prostaglandin stimulation of FP receptor. South African J. Sci. 92, Abs., p. 563.
18. Miller, C. W. and Ntambi, J. M. (1996). Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc. Natl. Acad. Sci. USA 93, 9443-9448.
17. Casimir, D. A., Miller, C. W. and Ntambi, J. M (1996). Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. Differentiation 60, 203-210.
16. Ntambi, J. M. and Takova, T. (1996). Role of Ca2+ in the early stages of murine adipocyte differentiation as evidenced by calcium mobilizing agents. Differentiation 60, 151-158.
15. Waters, K. and Ntambi, J. M. (1996). Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase 1 gene in diabetic mice. Lipids 31, S-33-S-36.
14. Ntambi, J. M., Sessler, A. M. and Takova, T. (1996). A model cell line to study regulation of stearoyl-CoA desaturase gene 1 expression by insulin and polyunsaturated fatty acids. Biochem. Biophys. Res. Commun. 220, 990-995.
13. Smulson, M. E., Kang, V. H., Ntambi, J. M., Rosenthal, D. S., Ding, R. and Simbulan, C. M. G. (1995). Requirement of the expression of poly (ADP-ribose) polymerase during the early stages of differentiation of 3T3-L1 preadiopcytes as studied by antisense RNA induction. J. Biol. Chem. 270, 119-127.
12. Ntambi, J. M. (1995) The regulation of stearoyl-CoA desaturase (SCD). Prog. Lipid Res. 34, 139-150.
11. Ntambi, J. M. (1995) Cellular differentiation and dietary regulation of gene expression. Prostaglandins Leukotrienes and Essential Fatty Acids 52, 117-120.
10. Waters, K. and Ntambi, J. M. (1994) Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression in liver of diabetic mice. J. Biol. Chem. 269, 27773-27777.
9. Pastano, G., Prince, A., Guyden, J., Ntambi, J. M., Atkin, A. and Boto, W. O. (1993) Independent divergence in the CD4 binding site and V3 loop encoded in two seroprevalent Ugandan HIV-1 clinical isolates. J. Acq. Immune Def. Syndromes 6, 872-80.
8. Ntambi, J. M. (1992) Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J. Biol. Chem. 267, 10925-10930.
7. Christy, R. J., Young, V. W., Ntambi, J. M., Geiman, D. E., Landschulz, W. H., Friedman, A. D., Nakabeppu, Y., Kelly, T. J. and Lane, M. D. (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: C/EBP interacts with and activates the promoters of two adipocyte-specific genes. Genes and Development 9, 1323-1335.
6. Kaestner, K. H., Ntambi, J. M., Kelly, T. J. and Lane, M. D. (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: A second differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 264, 14755-14761.
5. Ntambi, J. M., Buhrow, S. A., Kaestner, K. H., Sibley, E., Christy, R. J., Kelly, T. J. and Lane, M. D. (1988) Differentiation-induced gene expression in 3T3-L1 preadipocytes: Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 263, 17291-17300.
4. Ntambi, J. M., Ryan, K. A. and Englund, P. T. (1987) The replication origin in kinetoplast DNA minicircles from Trypanosoma equiperdum. In: Molecular Biology of Parasitic Invasion, Alan R. Liss, Inc., pp. 113-120.
3. Ntambi, J. M., Shapiro, T., Ryan, K. A. and Englund, P. T. (1986) Ribonucleotides associated with a gap in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. J. Biol. Chem. 261, 11890-11895.
2. Ntambi, J. M. and Englund, P. T. (1985) A gap at a unique location in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. J. Biol. Chem. 260, 5574-5579.
1. Ntambi, J. M., Marini, J. C., Bangs, J. D., Hajduk, S. L., Jiminez, H. E., Kitchin, P. A., Klein, V. A., Ryan, K. A. and Englund, P. T. (1984) The presence of bent helix in the fragments of kinetoplast DNA minicircles from several trypanosomatid species. Mol. Biochem. Parasitol. 12, 273-286.