Our History
The
Department of Biochemistry builds on a long tradition of excellence in
basic research that has led to important practical advances. A modern
department, with emphases in cellular regulation, molecular genetics,
protein structure, hormone action, virology, and developmental biology,
has been built on this strong historical foundation.
Our
department was founded in 1883. In the century since, its contributions
have dramatically changed our understanding of the chemical basis of
life and have illuminated how a molecular understanding of basic
biological problems can improve the human condition. The Department's
historical contributions are many and varied, and rank among the
highlights in the emergence and rise to prominence of biochemistry and
molecular biology.
Among the important discoveries made at the
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Department of Biochemistry are the:
- Development of the first reliable measurements of milk quality
- Discovery of Vitamin A and the Vitamin B complex
- Discovery of the irradiation process for production of Vitamin D and elimination of rickets
- Isolation of niacin and elimination of pellagra
- Discovery of methods of treating nutritional anemia
- Isolation of active vitamin B6 derivatives
- Development of fermentation methods that led to the large-scale preparation of penicillin and other antibiotics
- Development of methods for preservation of sperm, triggering the artificial insemination industry
- Discovery of the anti-coagulants dicoumarol and warfarin and their uses against heart disease and as rodenticides
- Discovery of the key features of the incorporation of atmospheric nitrogen into amino acids
- First chemical synthesis of a gene
- Development of methods for the kinetic analysis of enzyme reactions
- Discovery and identification of the hormonal form of Vitamin D, and use of its analogs to treat disease
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Among
the faculty who contributed to this outstanding array of
accomplishments have been a long line of colorful, opinionated and
visionary scientists, among them Stephen Babcock, E. B. Hart, Conrad
Elvehjem, E. V. McCollum, Harry Steenbock, Marvin Johnson, Robert
Burris, Karl Paul Link, Esmond Snell,1968 Nobel Laureate Gobind Khorana,
and Henry Lardy. Among the past and present members of the department
are 18 members of the National Academy of Sciences. The Department of
Biochemistry has trained over 1,300 PhDs, including 1997 Nobel Laureate Paul Boyer and 1972 Nobel Laureate Stanford Moore.
These alumni occupy important scientific and executive positions
throughout the world. At present, the Department is comprised of 120
graduate students, 80 postdoctoral investigators, 60 technicians, 30
faculty, and 400 undergraduates. The current department strongly
emphasizes outstanding research, while its highly effective teaching
program has won campus-wide recognition through awards for classroom
instruction. Outstanding teachers include David Nelson and Michael Cox,
the authors of a widely-used Biochemistry textbook.
On
this proud foundation, driven by a desire to find the molecular
explanation for basic biological phenomena, the Department's interests
have widened and grown to embrace an ever-increasing diversity of areas
and organisms. Central problems in developmental biology, protein
structure and function, molecular genetics, nutrition, metabolism,
enzymology, and more, dominate the intense research environment; the
breadth of approaches is invigorating, and spans molecular biology,
protein structure, molecular physiology and endocrinology, and
synthetic and analytical chemistry. Interdisciplinary research is not
only possible, but expected.
The desire to find
molecular answers to fundamental problems in the biology and chemistry
of life is the driving force of this department. To explore the present
research interests of our faculty go to the Faculty web page.
The Department relishes the challenges ahead, combining its modern
methodologies and pioneering approaches with its established
traditions, in an ambitious effort to understand the molecular basis of
life.
The Department of Biochemistry builds on a long
tradition of excellence in basic research that has led to important
practical advances. A modern department, with emphases in cellular
regulation, molecular genetics, protein structure, hormone action,
virology, and developmental biology, has been built on this strong
historical foundation.
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Biochemistry 1912

Biochemistry 1917

Biochemistry 1937 addition

Biochemistry 1957 addition

Biochemistry 1985 addition

Biochemistry 1998 Addition

Babcock & Others

Elvehjem

Link

DeLuca
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