News 2003
 
November 1, 2003
 
James Ntambi is the recipient of the 2004 Osborne Mendel Award given by the American Institute of Nutritional Sciences   

This award recognizes Professor Ntambi's outstanding scientific contributions towards understanding adipocyte differentiation and the regulation of gene expression involved in lipid metabolism, and the profound influence this work will have on the field of obesity research in the coming years. A formal presentation of the award will take place at the ASNS Awards Programin Washington, D.C., April, 2004.



October 1, 2003
 
COLLABORATION COULD HELP CHART THE PROTEIN UNIVERSE   

The billions of proteins that compose life on Earth remain one of the truly uncharted territories in the biological universe, due mainly to the slow and arduous techniques their exploration requires.

Now, a research partnership between the University of Wisconsin-Madison and a Japanese university and company aims to develop a technology that may allow scientists to map the shapes and structures of proteins more easily than ever before. The advance promises to help unlock the inner workings of hundreds or even thousands of proteins, according to UW-Madison biochemistry professor John Markley, leading to a better understanding of protein-based diseases, and providing fundamental new information about the building blocks of all living beings, from bacteria to plants to people.

An agreement signed this week by the UW-Madison's Center for Eukaryotic Structural Genomics (CESG), the university's patent management agency the Wisconsin Alumni Research Foundation (WARF), Ehime University in Matsuyama, Japan, and the Japanese biotechnology company Cell-Free Sciences of Yokohama, formalizes an ongoing collaboration between these groups to refine a powerful new system, created in Japan, for making the large quantities of purified protein that biochemists need to solve protein structures.

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September 2, 2003
 
Ron Raines receives an Arthur C. Cope Scholar Award   

Ron Raines has been named a 2004 recipient of the Arthur C. Cope Scholar Award by the American Chemical Society. The Cope Scholar Award is given to recognize and encourage excellence in organic chemistry, and consists of $5,000, a certificate, and a $40,000 unrestricted research grant. Raines has won several other national awards for his research on protein chemistry/biology, including the 1998 Pfizer Award in Enzyme Chemistry from the American Chemical Society and a 2001-2002 Guggenheim Fellowship. He is a Fellow of the American Association for the Advancement of Science.



September 1, 2003
 
Mouse Resists Diabetes   

An engineered mouse, already known to be immune to the weight gain ramifications of a high-calorie, high-fat diet, now seems able to resist the onset of diabetes.

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July 1, 2003
 
MOTHER OF ALL NMR MAGNETS TO BOLSTER UW-MADISON LAB   

Now, with support from the National Institutes of Health, UW-Madison's National Magnetic Resonance Facility will be home to a machine capable of generating the largest NMR-quality magnetic field possible with current technology.

A $5 million award from NIH's National Institute of General Medical Sciences paves the way for the fall deployment of an 11-ton, 900-megahertz NMR magnet that will position the lab to remain as one of the top NMR research facilities in the world, says biochemistry professor John Markley,

"This system will enable us to examine biological processes we haven't been able to attack before," Markley says.

Markley, who led the effort to bring this technology to Wisconsin, is one of 36 researchers from around the country with grant funding from the National Institute of General Medical Sciences who plan to use the power of the new instrument to advance their research.

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April 26, 2003
 
Dave Nelson nominated for an Alliant Energy Underkofler Teaching Award   

In addition to the Distinguished Teaching Awards presented by the University of Wisconsin-Madison each year, the UW System also recognizes classroom excellence by way of its Alliant Energy Underkofler Teaching Awards. This year, David L. Nelson, professor of biochemistry, and Michael J. Smith, Robert Ratner Professor of Industrial Engineering, are candidates from the Madison campus.

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April 25, 2003
 
Judith Kimble receives 2002-3 Hilldale Award in the Biological Sciences.   

The Hilldale awards are presented each year to four faculty members, one from each faculty division, in recognition of a distinguished contribution ot teaching, research, and extension/outreach while a member of the faculty of the University of Wisconsin-Madison. The Hilldale Awards are made possible by the Hilldale Fund, which receives income from the operation of the Hilldale Shopping Center. The funds are used to support important University programs designed to advance scholarly activity at the UW-Madison.

Hilldale Undergraduate Research Awards.

Grants from the Hilldale Foundation and the Wisconsin Legislature provide $4,000 each to undergraduate students and $1,000 to the faculty or staff supervisors to work in collaboration on research projects.

Federhart, Katherine, Margaret Clagett-Dame, Biochemistry
Keller, Melissa, Richard Amasino, Biochemistry
Riebau, Anne, Samuel Butcher, Biochemistry



April 24, 2003
 
George Phillips has received a Vilas Associate Award   

The Vilas Trustees have made possible this form of recognition for faculty in the Biological Sciences Division and will provide research support during 2003-04 and 2004-05.



April 23, 2003
 
Marv Wickens has been appointed as the Max Perutz Professor of Molecular Biology   

Marv Wickens has received a WARF-named Professorship: Max Perutz Professor of Molecular Biology. Prof. Wickens research has always focused on how genes work in animal cells. He has concentrated on events after DNA has been transcribed into RNA, en route to being translated into protein. He has analyzed both how mRNAs are born in the nucleus and how they are controlled in the cytoplasm. He has served extensively with the National Institutes of Health, as a member of the N.I.H. Center for Scientific Review Advisory Committee, and as member and Chairman of the N.I.H. Molecular Biology Study Section. He has been President of the RNA Society, and served as an editor of several scientific journals. He has mentored numerous talented graduate students and post-doctoral fellows at U.W., and is deeply gratified by their own successes.

Max Perutz
A pioneer and founder of molecular biology, Max Perutz attended the University of Vienna. In 1936, he moved to the University of Cambridge to begin Ph.D. work with J.D. Bernal, and there established a long-standing connection to the Cavendish laboratory. In 1962, he founded the Medical Research Council Laboratory for Molecular Biology, of which was chairman until 1979. There, he helped create an atmosphere in which new ideas were welcome, and big problems exactly the right ones to take on. The unique blend of creativity, colleagiality and commitment, was pivotal in the birth of molecular biology, and led to eleven Nobel Prizes. As a scientist, Perutz pioneered the use of X-ray crystallography to study the structure of proteins. In 1953 he developed a method to interpret the X-ray diffraction patters of large molecules. Using that approach, he and his colleague, John Kendrew, determined the first protein structures, those of hemoglobin and myoglobin. For this work, they were awarded the 1962 Nobel Prize in Chemistry. Dr. Perutz was a prolific and talented writer of popular articles and book reviews, and is remembered not only for his science, but for his interest in and warm support of the work of others. The WARF Named Professorship awards are made possible by the impressive research efforts of UW-Madison faculty and staff. Technology arising from these research efforts is licensed by our patent management organization, the Wisconsin Alumni Research Foundation (WARF), to industry. Income from successful licenses is returned to the Graduate School to fund a variety of research activities throughout the divisions on campus, including these awards.



April 22, 2003
 
Everson Lecture in Biochemistry   

Dr. Dawn Braseamle

Defining the Lipid Storage Droplet: Unique Proteins Associated with a Dynamic Subcellular Compartment

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March 21, 2003
 
4th Annual Biochemistry egg drop - 3pm in the west atrium   

Materials will be handed out on March 14th. Winners will be determined by surviving all three drops, landing the closest to the target, and using smallest number of items on the list.

This years' winners were from the Pike Lab. Second place went to the Friesen lab.



March 11, 2003
 
Topics in Medical Biochemistry - Biochemistry 550 - Colleen Hayes   

Poster session in the west atrium - "Current advances in HIV/AIDS therapeutics and research findings that may open up new avenues for alternative approaches to treating HIV/AIDS" that may open up new avenues for each of the 11 groups in the class would be presenting a recent paper on a topic that touches HIV/AIDS therapeutics. This is a good opportunity to be updated on how far along research in this important field has gone in the last two years and how much more it would take to finally defeat HIV.



February 26, 2003
 
Ivan Rayment received the WARF Mid-Career Award   

Ivan Rayment has an international reputation in structural biology. In establishing a state-of-the-art X-ray crystallography laboratory at Wisconsin, Rayment has created a campus resource that also contributes to research training and teaching.

KELLETT MID-CAREER AWARD

This award is intended to recognize and support mid-career faculty, five to twenty years past their first promotion to a tenured position. The Mid-Career award was created to provide needed support and encouragement to faculty at a critical stage of their careers.

The Kellett Mid-Career awards are made possible by the impressive research efforts of UW-Madison faculty and staff. Technology arising from these research efforts is licensed by our patent management organization, the Wisconsin Alumni Research Foundation (WARF), to industry. Income from successful licenses is returned to the Graduate School to fund a variety of research activities throughout the divisions on campus, including these awards.



February 15, 2003
 
Marcia Moss Graduate Award   

Kimberly A. Dickson was selected to receive the first Marcia Moss Graduate Award in Biochemistry.



February 14, 2003
 
Plant Pysiology cover   

Leaf senescence is a developmental program in which nutrients are recycled from leaves at the end of their lifespan. In annual plants, these recycled nutrients often support seed development. In deciduous trees, the nutrients can be stored in Autumn to support the growth of new tissues in the Spring. Thus leaf senescence is of great practical value to plants, and the cover photograph of a maple tree by Jordan Hall at Indiana University illustrates the aesthetic value of this process. To further understand this nutrient-recycling program at a molecular level, Bhalerao et al. (pp. 430-442) have studied, using microarrays, the changes in gene expression that occur as leaf senescence is initiated in poplar trees. Their work reveals a broad range of genes which, at the mRNA level, change in expression during leaf senescence (image from Rick Amasino).



February 13, 2003
 
Predicting adult-onset diabetes   

Fat cells may hold the key to predicting type 2 diabetes, a major cause of kidney failure, limb amputations, blindness, heart disease and stroke.

The disease, also called adult-onset diabetes, affects 8 percent of the U.S. population age 20 or older. While more than 80 percent of diabetics are overweight, only 10 percent of obese individuals develop the disease. Knowing your risk is a key to prevention.

Knowing what to expect: "Currently, we have no markers to tell who among these overweight individuals is going to become diabetic," says Alan Attie, a College biochemist who studies diabetes. A major study in 2001 showed that people at risk for diabetes can delay the onset of the disease with moderate changes in diet and exercise, according to Attie.

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February 12, 2003
 
Second Annual Biochemistry Art Show Opens   

Please join us in celebrating the talents of our peers
First Floor, Biochem Addition

Show runs through the end of March.



February 10, 2003
 
Paul Boyer Award for Outstanding PostDoctoral Studies in biochemistry   

The 2003 Recipients will present their talks at 3:30 pm in B1118 Biochemistry.

Scott Michaels
Memories of winter: the central role of FLOWERING LOCUS C in the regulation of flowering time in Arabidopsis

Christian Eckmann
Mining for Gold - Cell Fate Decisions in the C. elegans Germline

Paul Delos Boyer
is a native of Provo, Utah where he graduated from Brigham Young University in 1939. He was a graduate student in the UW-Madison Biochemistry Department with Professor Paul Phillips and finished his Ph.D. in 1943. After 17 years as a faculty member at the University of Minnesota, he moved to UCLA where in 1965 he became founding Director of UCLA's Molecular Biology Institute.
As a graduate student he discovered the role of potassium as a co-factor for pyruvate kinase. This was the first evidence for an alkaline metal cation participating in enzyme atalysis. He continued studying enzymes throughout his career and served as editor of the multi-volume treatise" The Enzymes". paul is best known for revealing the binding change mechanism for ATP synthasa involving a novel rotational catalysis.
Paul?s achievements have been recognizing in many awards: Nobel Prize in Chemistry, 1997; Rose Award, American Society of Biochemistry and Molecular Biology; American Chemical Society Award in Enzyme Chemistry; Honorary Doctorates-Stockholm, 1974; University of Minnesota, 1996; University of Wisconsin, 1998. He is a member of the National Academy of Science, the American Academy of Arts and Sciences.
Despite all the professional responsibilities Paul and his wife Lyda find time for tennis, biking, golf, and building homes. They have supervised construction and furnishing of three, giving Paul an outlet for his carpentry skills.



January 14, 2003
 
Michelle Soltero has been chosen to receive this year's Sigrid Leirmo Memorial Award in Biochemistry   

The award, provided by funds given in memory of Dr. Leirmo by her husband, consists of $250, and will be awarded at the departmental poster session on February 7. The award is designated for a graduate or postdoctoral student who best exemplifies the spirit of Sigrid Leirmo, who received her Ph.D. degree in the Department of Biochemistry in 1989 and was a postdoctoral research associate in the Department of Bacteriology when she died tragically in an accident in October 1990. Dr. Leirmo was widely acknowledged among her fellow students and colleagues both as a promising researcher and as an enthusiastic friend and mentor. The award is to be given to a postdoctoral or graduate student who displays clear promise as a research scientist. Most importantly, the award is to be designated in appreciation of the student's consistent willingness to contribute to the intellectual and technical potential of his or her fellow students and colleagues through selfless help of others.

Michelle Soltero, who is a fifth year graduate student in the laboratory of Dr. Laura Kiessling, should receive her Ph.D. degree in Spring Semester 2004. The results of her research, which has been focused on the flavoprotein UDP-galactofuranose mutase, are being prepared for publication. Michelle was cited for her genuine interest in the work of others and willingness to help them in an unselfish manner. She has been a member of the Student Faculty Liaison Committee for all of her time in Grad School, and instigated the very successful first annual Departmental Art Show last year. She is currently planning the second annual art show, and has been organizing the biennial Life Sciences Careers Day.



 

 

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