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SUBTRACT A GENE AND FEASTING MICE ADD NO FAT - 8/12/2002
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By subtracting a single gene from the genome of a mouse, scientists
have created an animal that can eat a rich, high-fat diet without
adding weight or risking the complications of diabetes, according to a
new study published this week.
Writing in the online editions of the Proceedings of the National Academy of Sciences (PNAS), James M. Ntambi, a professor of biochemistry and of nutritional sciences at the
University of Wisconsin-Madison and colleagues report that mice lacking
a gene known as SCD-1 can eat a rich high-fat diet and avoid the
consequences of fat deposition and excess sugar in the blood, the
hallmark of type II diabetes.
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