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Publications

Tu, Z., Keller, M.P., Zhang, C., Rabaglia, M.E., Greenwalt, D.M., Yang, X., Wang, I.M., Dai, H., Bruss, M.D., Lum, P.Y., Zhou, Y.P., Demp, D.M., Dendziorski, C.M., Yandell, B.S., Attie, A.D., Schadt, E.E., Zhu, J. (2012) Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. PLoS Genetics e1003107. PMID 23236292.

Kimple, M.E., Keller, M.P., Rabaglia, M.R., Pasker, R.L., Truchan, N.A., Brar, H.K., and Attie, A.D. (2013) Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose and hormone-stimulated insulin secretion. Diabetes 62,1904-1912. PMID 23349487.

Neto E.C., Broman A.T., Keller M.P., Attie A.D., Zhang B., Zhu .J, Yandell B.S. (2013) Modeling causality ofr pairs of phenotypes in system genetics. Genetics 193,1003-1013.

Lane, R.F., Steele, J.W., Cai, D., Ehrlich, M.E., Attie, A.D., and Gandy, S. (2013) Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide. J. Neurosci 33,7099-7107. PMID 23595767.

Haas, M.E. Attie, A.D., and Biddinger, S.B. (2013) The regulation of apoB metabolism by insulin. Trends Endocrinol. Metab.  24, 391-397. PMID 2372961.

Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. (2013) Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J. Biol. Chem. 288,26209-26219. PMID 23864654.

O’Halloran, T.V., Kebede, M., Phillips, S.J., and Attie, A.D. (2013) Zinc, insulin and the liver: a ménage a trois. J. Clin. Invest. 123,4136-4139. PMID 24051373.

Grimsrud, P.A., Carson, J.J., Hubler, S.L., Hegert, A.S., Bailey, D.J., Stapleton, D.S., Keller, M.P., Westphall, M.S., Yandell, B.S., Attie, A.D., Coon, J.J., and Pagliarini, D. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals post-translational control of ketogenesis. Cell Metabolism 16,672-683. PMID 23140645.

Neto EC, Keller MP, Broman A, Attie AD, Jansen RC, Broman KW, and Yandell BS. (2012) Quantile-based permutation thresholds for QTL hotspots. Genetics 191(4):1355-1365.

Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis AJ, Attie AD, Yandell BS, and Medrano JF. (2012) Genome scans for transmission ratio distortion regions in mice. Genetics. 191(1):247-59.

Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, and Attie AD. (2011) Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn‑2, a Negative Regulator of Insulin Secretion. PLoS Genetics 7,e1002323.

Raines SM, Richards OC, Schneider LR, Schueler KL, Rabaglia ME, Oler AT, Stapleton DS, Genové G, Dawson C, and Attie AD. (2011) Loss of PDGF-B activity increases hepatic vascular delivery of insulin and enhances insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 301,517-526.

Wang P, Dawson JA, Keller MP, Yandell BS, Thornberry NA, Zhang BB, Wang IM, Schadt EE, Attie AD, and Kendziorski CM. (2011) A Model Selection Approach for Expression Quantitative Trait Loci (eQTL) Mapping. Genetics 187, 611-621.

Keller MP and Attie AD. (2010) Physiological insights gained from gene expression analysis in obesity and diabetes. Ann. Rev. Nutr. 30,341-364.

Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, MacNeil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski, CM, Yandell BS, Caxtro V, Attie AD, Kaplan LM, Schadt EE. (2010) Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genetics 6(5):e1000932.

Lavine, JA, Raess PW, Stapleton DS, Rabaglia ME, Suhonen JI, Schueler KL, Koltes JE, Dawson JA, Yandell BS, Samuelson LC, Beinfeld MC, Davis DB, Hellerstein MK, Keller M.P, And Attie AD. (2010) Cholecystokinin is Up-regulated in obese islets and expands beta-cell mass by increasing beta-cell survival. Mol. Endocrinol 151,3577-3588.

Hudkins K, Pichaiwong W, Wietecha T, Kowalewska J, Banas M, Spencer M, Mühlfeld A, Koelling M, Pippin J, Shankland S, Askari B, Rabaglia ME, Keller MP, Attie AD, Alpers CE. (2010) BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. J. Am. Soc. Nephrol. 21, 1553-1542.

Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell B.S., Keller MP, Wang IM, Schadt EE, and Attie AD (2010) FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol. Endocrinol. 24, 1822-1834.

Babak T, Garrett-Engele P, Armour CD, Raymond CK, Keller MP, Chen R, Rohl CM, Johnson JM, Attie AD, Fraser HB, and Schadt EE. (2010) Genetic validation of whole-transcriptome sequencing for mapping cis-regulatory variation. BMC Genomics 11, 473.

Attie AD and Keller MP. (2010) Gene co-expression modules and type 2 diabetes. Results Probl Cell Differ. 52, 47-56. PMID: 20865371.

Lane RF, Raines SM, Lah JJ, Small SA, Tanzi RE, Attie AD, and Gandy S. Diabetes-linked SORCS1, a g-secretase substrate and regulator of Alzheimer’s APP metabolism, forms complexes with multiple Alzheimer’s-linked proteins (APP, PS1, BACE, VPS35, and SORLA). J. Neurosci. 30, 13110-13115. PMID: 20881129

Lavine JA and Attie AD. (2010) Gastrointestinal hormones and the regulation of beta-cell mass. Ann NY Acad Sci 12,41-58.

Neto EC, Keller MP, Attie AD, and Yandell BS. (2010) Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes. Ann Appl Stat 4(1):320-339.

Newgard CB, Attie AD. (2010) Getting biological about the genetics of diabetes. Nat Med. 16(4):388-91.

Richards OC, Raines SM, Attie AD. (2010) The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr Rev. 31(3):343-63. supplemental:

Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, Choi YJ, Kleinhanz R, Shang J, Zhou YP, Howard AD, Zhang BB, Kendziorski C, Thornberry NA, Yandell BS, Schadt EE, Attie AD. (2009) Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome. 20(8):476-85.

Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH. (2009) The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol. 23(10):1702-12. supplimental:

Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE. (2009) Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol. 29(16):4467-83.

Attie AD, Scherer PE. (2009) Adipocyte metabolism and obesity. J Lipid Res. 50 Suppl:S395-9. Review.

Lusis AJ, Attie AD, Reue K. (2008) Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet. 9(11):819-30. Review.

Attie AD, Witztum JL, Edwards PA, Lusis AJ. (2008) In Memoriam: Roger A. Davis (1945-2008). J Lipid Res. 49(11):2279-80.

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A. (2008) Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J. 22(10):3581-94. supplimental:

Davis RA, Attie AD. (2008) Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool. Proc Natl Acad Sci USA. 1;105(13):4965-6.

Chaibub Neto E, Ferrara CT, Attie AD, Yandell BS. (2008) Inferring causal phenotype networks from segregating populations. Genetics. 179(2):1089-1100.

Keller MP, Choi Y, Wang P, Belt Davis D, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD. (2008) A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res. 18(5):706-716.

Blasiole DA, Oler AT, Attie AD. (2008) Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem. 283(17):11374-11381.

Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD. (2008) Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet. 4(3):1000034.

Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM, Attie AD. (2008) Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics. 33(3):361-372.

Oler AT, Attie AD. (2008) A rapid, microplate SNP genotype assay for the leptinob allele. J Lipid Res. 49(5):1126-1129.

Blasiole D.A., Davis R.A., Attie A.D. (2007) The physiological and molecular regulation of lipoprotein assembly and secretion. Mol Biosyst. 3(9):608-19.

Nassoury, N., Blasiole, D., Oler, A.T., Hamelin, J., Prat, A., Attie, A.D., and Seidah, N.G. (2007) The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic  8, 718-732.

Goodarzi, M.O., Lehman, D.M., Taylor, K.D., Guo, X., Cui, J., Quiñones, J.J., Clee, S.M., Hsueh, W.A., Yang, H., Attie, A.D., Stern, M.P., Rotter, J.I. (2007) SORCS1: A novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes 56, 1922-1929.

Clee, S.M. and Attie, A.D. The genetic landscape of type 2 diabetes in mice. Endocrine Reviews. 28(1):48-83.

Attie, A.D., Sober, E., Numbers, R.L., Amasino, R.M., Cox, B., Berceau, T., Powell, T., and Cox, M.M. (2006) Defending science education against intelligent design: a call to action. J. Clin. Invest.116, 1134-1138.

Attie, A.D. (2006) A Liver-High-Density Lipoprotein-Ovarian Axis of Fertility. Endocrinology 147(4):1575-1576.

Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards, O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Stapleton, D.S., Gray-Keller, M.P., Boronenkov, I., Raess, P.W., Flowers, M.T., and Attie, A.D. (2006) Positional cloning of a type 2 diabetes quanitative trait locus. Nature Genetics 38, 688-693.

Lan, H. Chen, M., Byers, J.E., Yandell, B.S., Stapelton, D.S., Mata, C.M., Mui, E.T., Flowers, M.T., Scheuler, K.L., Manly, K.F., Williams, R.W., Kendziorski, C.M., Attie, A.D. (2006) Combined expression trait correlations and expression quantative trait locus mapping. PLoS Genetics 2:52-61.

Kendziorski, C. M. ,Chen, M., Yuan, M., Lan, H. and Attie, A. D. (2005) Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping. Biometrics DOI: 10.1111/j.1541-0420.

Rabagia, M.E., Gray-Keller, M.P., Attie, A.D. (2005) α-Ketoisocaproate-induced Hypersecretion of Insulin by Islets from Diabetes-susceptible Mice: A Role for α-ketoglutarate as a direct insulin secretagogue. Am. J. Physiol. 289, E218-E224.

Minn, A.H., Lan, H., Rabaglia, M.E., Harlan, D.M., Peculis, B.A., Attie, A.D., and Shalev, A. (2005) Increased insulin translation from an insulin splice-variant overexpressed in diabetes and insulin resistance. Mol. Endocrinol. 19, 794-803.

Clee, S.M., Nadler, S.T., Attie, A.D. (2005) Genetic and genomic studies in the BTBR ob/ob Model of type 2 diabetes. Am. J. Ther. 12, 491-498.

Sheth, S.S., Castellani, L.W., Chari, S., Wagg, C., Thipphavong, C.K., Bodnar, J.S., Tontonoz, P., Attie, A.D., Lopaschuk, G.D., and Lusis, A.J. Thioredoxin interacting protein (Txnip) deficiency disrupts the fasting-feeding metabolic transition. (2005) J. Lipid Res. 46, 123-134.

Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat A, Seidah NG. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. (2004) J Biol Chem. 279, 48865-75.

Jin, C., Lan, H., Attie, A.D., Bulutuglo, D., Churchill, G.A., and Yandell, B.S. (2004) Selective phenotyping for increased efficiency in mapping studies. Genetics 168, 2285-93.

Hui, T.Y., Sheth, S., Diffley, J.M., Potter, D.W., Lusis, A.J., Attie, A.D., and Davis, R.A. (2004) Mice lacking thiroedoxin interactin protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J. Biol. Chem. 279, 24387-24851.

Attie, A.D. (2004) Insig: a significant integrator of hormonal and nutritional signals. J. Clin. Invest. 113, 1112-1114.

Attie, A.D. (2004) The mystery of PCSK9. Arteroscl. Thromb. Vasc. Biol. 24,1337-1339.

Lan, H., Rabaglia, M.E., Schueler, K.L., Mata, C., Yandell, B.S., and Attie, A.D. (2004) Distinguishing co-variation from causality in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait. Diabetes 53, 240-244.

Stoehr, J.P., Byers, J.E., Clee, S.M., Lan, H., Boronenkov, I., Schueler, K.M., Yandell, B.S., and Attie, A.D. (2004) Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes 53, 245-249.

Lan, H., Rabaglia, M.E., Stoehr, J.P., Nadler, S.T., Schueler, K.L., Zou, F., Yandell, B.S., and Attie, A.D. (2003) Gene expression profiles of non-diabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52, 688-700.

Lan, H., Stoehr, J.P., Nadler, S.T, Schueler, K.M., Yandell, B.S., and Attie, A.D. (2003) Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics 164, 1607-1614.

Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2003) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Parmigiani, ES Garrett, RA Irizarry, SL Zeger. Springer-Verlag.

C.M. Kendziorski, Y. Zhang, H. Lan, A.D. Attie, (2003) The efficiency of pooling mRNA in microarray experiments. Biostatistics 465-477.

Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2002) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Lan, H., Rabaglia, M.E., Stoehr, J.P.

Ntambi, J.M., Miyazaki, M., Stoehr, J.P., Lan, H., Kendziorski, C.M., Yandell, B.S., Cohen, P., Friedman, J.M., and Attie, A.D. (2002) Loss of Stearoyl CoA Desaturase-1 Function Protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99, 11482-11486.

Attie, A.D., Hamon, Y., Brooks-Wilson, A.R., Gray-Keller, M.P., MacDonald, M.L.E., Rigot, V., Tebon, A., Zhang, L-H., Mulligan, J., Singaraja, R.R., Bitgood, J.J., Cook, M.E., Kastelein, J.J.P., Chimini, G., and Hayden, M.R. (2002) Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J. Lipid Res. 43, 1610-1617.

Attie, A.D., Krauss, R.M., Gray-Keller, M.P., Brownlie, A., Miyazaki, M., Kastelein, J.J., Lusis, A.J., Stalenhoef, A.F.H., Stoehr, J.P., Hayden, M.R., and Ntambi, J.M. (2002) Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 43, 1899-1907.

Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, and Attie, Alan D. (2002) Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B. PNAS 99(7):4337-4342.

Attie, A.D., Kastelein, J.P., and Hayden, M.R. (2001) Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42,1717-1726.

Nadler, S.T., Stoehr, J.P., Rabaglia, M.A., Schueler, K.L., Birnbaum, M.J., and Attie, A.D. (2001) Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice. Am. J. Physiol. 249, E1249-E1254.

Nadler, S.T. and Attie, A.D. (2001) Please pass the chips. Genomic Insights into obesity and diabetes. 
J. Nutrition 131, 2078-2081.

Stoehr, J.P., Nadler, S.T., Schueler, K.L., Rabaglia, M.E., Yandell, B.S., Metz, S.A., and Attie, A.D. (2000) Genetic obesity unmasks non-linear interactions between murine Type 2 Diabetes susceptibility loci. Diabetes 49, 1946-1954.

Nadler, S.T., Stoehr, J.P., Schueler, K.M., Tanimoto, G., Yandell, B.S., and Attie, A.D. (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus.  Proc. Natl. Acad. Sci. USA 97, 11371-11376.

Twisk, J., Gillian-Daniel, D.L., Tebon, A., Barrett, P.H.R., and Attie, A.D. (2000) The role of the LDL receptor in apolipoprotein B secretion.  J. Clin. Invest. 105, 521-532.

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